Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets

Science

Volumn 333, Issue 6043, 2011, Pages 724-729

  Yuan, Jing ^a   Cheng, Ken Chih Chien ^b   Johnson, Ronald L ^b,d   Huang, Ruili ^b   Pattaradilokrat, Sittiporn ^a   Liu, Anna ^a   Guha, Rajarshi ^b   Fidock, David A ^c   Inglese, James ^b   Wellems, Thomas E ^a   Austin, Christopher P ^b   Su, Xin Zhuan ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^c NewYork Presbyterian Hospital   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMODIAQUINE; ANTIALLERGIC AGENT; ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; ANTIHYPERTENSIVE AGENT; ANTIINFECTIVE AGENT; ANTIMALARIAL AGENT; ANTINEOPLASTIC AGENT; ANTIOBESITY AGENT; ANTIPARASITIC AGENT; ARTEMETHER; ATOVAQUONE; BENFLUMETOL; CICLESONIDE; CINCHONINE; CLINDAMYCIN; DESERPIDINE; DETERGENT; DIHYDROARTEMISININ; DIHYDROERGOCRISTINE; DYE; ERGOTAMINE; HALOFANTRINE; LESTAURTINIB; MEFLOQUINE; PACLITAXEL; PROTEIN TYROSINE KINASE INHIBITOR; RIFAPENTINE; TETRAHYDROLIPSTATIN; UNINDEXED DRUG;

ALLELE; CHROMOSOME; CONCENTRATION (COMPOSITION); DISEASE CONTROL; DRUG RESISTANCE; GENETIC ANALYSIS; GENETICALLY MODIFIED ORGANISM; GENOMICS; MALARIA; PARASITE; PHENOTYPE;

ANTIMALARIAL ACTIVITY; ARTICLE; CHIRALITY; DRUG RESEARCH; DRUG TARGETING; GENETIC ANALYSIS; GENOME; GENOMICS; HIGH THROUGHPUT SCREENING; MALARIA; NONHUMAN; PARASITE; PHENOTYPE; PLASMODIUM FALCIPARUM; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ANTIMALARIALS; BIOLOGICAL EVOLUTION; CHROMOSOME MAPPING; DRUG COMBINATIONS; DRUG RESISTANCE; GENES, PROTOZOAN; GENETIC LINKAGE; GENETIC LOCI; GENOME, PROTOZOAN; GENOME-WIDE ASSOCIATION STUDY; HIGH-THROUGHPUT SCREENING ASSAYS; INHIBITORY CONCENTRATION 50; MEMBRANE TRANSPORT PROTEINS; MOLECULAR STRUCTURE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; MUTATION; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTOZOAN PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79961240592     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1205216     Document Type: Article

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