Atomic dissection of the hydrogen bond network for transition-state analogue binding to purine nucleoside phosphorylase

Biochemistry

Volumn 41, Issue 49, 2002, Pages 14489-14498

  Kicska, Greg A ^a   Tyler, Peter C ^b   Evans, Gary B ^b   Furneaux, Richard H ^b   Shi, Wuxian ^a   Fedorov, Alexander ^a   Lewandowicz, Andrzej ^a   Cahill, Sean M ^a   Almo, Steven C ^a   Schramm, Vern L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b CALLAGHAN INNOVATION   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CRYSTAL STRUCTURE; DISSOCIATION; ENZYMES; HYDROGEN BONDS;

ATOMIC DISSECTION;

BIOCHEMISTRY;

1 (9 DEAZAHYPOXANTHIN 9 YL) 1,4 DIDEOXY 1,4 IMINORIBITOL; 9 DEAZAHYPOXANTHINE; 9 DEAZAINOSINE; CARBENE; ENZYME INHIBITOR; HYDROGEN; HYPOXANTHINE DERIVATIVE; IMINORIBITOL; IMMUCILLIN G; IMMUCILLIN H; NUCLEOSIDE DERIVATIVE; NUCLEOSIDE PHOSPHORYLASE; PURINE; RIBITOL; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CATALYSIS; CATTLE; CHEMICAL MODIFICATION; CRYSTAL STRUCTURE; DISSECTION; DISSOCIATION CONSTANT; ENZYME BINDING; ENZYME INHIBITION; ENZYME STRUCTURE; EQUILIBRIUM CONSTANT; HYDROGEN BOND; MOLECULAR INTERACTION; NONHUMAN; PHASE TRANSITION; PKA; PRIORITY JOURNAL; PROTEIN ANALYSIS; STRUCTURE ANALYSIS;

ANIMALS; ASPARAGINE; BINDING SITES; CATALYSIS; CATTLE; CRYSTALLOGRAPHY, X-RAY; ELECTROSTATICS; ENZYME INHIBITORS; GLUTAMIC ACID; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; HYPOXANTHINE; IMINES; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PURINE-NUCLEOSIDE PHOSPHORYLASE; PYRIMIDINONES; PYRROLES; RIBONUCLEOSIDES; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

BOS TAURUS; BOVINAE;

EID: 2242437134     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi026636f     Document Type: Article

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