Identification of plasmepsin inhibitors as selective anti-malarial agents using ligand based drug design

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 11, 2011, Pages 3335-3341

  McKay, Paul B ^a   Peters, Martin B ^a   Carta, Giorgio ^a   Flood, Christopher T ^a   Dempsey, Enda ^b   Bell, Angus ^b   Berry, Colin ^c   Lloyd, David G ^a   Fayne, Darren ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b Moyne Institute of Preventive Medicine   (Ireland)

^c CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Aspartyl proteases inhibitor; Catalyst; Ligand based drug design; Malaria; Plasmepsin inhibitors

Indexed keywords

ANTIMALARIAL AGENT; CATHEPSIN D; MDG 418; MDG 419; MDG 420; MDG 421; MDG 422; MDG 423; MDG 424; MDG 425; MDG 426; MDG 427; MDG 428; MDG 429; MDG 430; MDG 431; MDG 432; MDG 433; MDG 434; MDG 435; PLASMEPSIN INHIBITOR; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; DRUG DESIGN; DRUG IDENTIFICATION; DRUG SCREENING; DRUG STRUCTURE; ENZYME INHIBITION; NONHUMAN; PHARMACOPHORE; PLASMODIUM FALCIPARUM;

ANTIMALARIALS; ASPARTIC ACID ENDOPEPTIDASES; ASPARTIC ACID PROTEASES; DRUG DELIVERY SYSTEMS; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PLASMODIUM FALCIPARUM;

PLASMODIUM FALCIPARUM;

EID: 79956153052     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.04.015     Document Type: Article

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