High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase

Journal of Biological Chemistry

Volumn 280, Issue 23, 2005, Pages 21847-21853

  Baldwin, Jeffrey ^a   Michnoff, Carolyn H ^a   Malmquist, Nicholas A ^a   White, John ^b   Roth, Michael G ^a   Rathod, Pradipsinh K ^b   Phillips, Margaret A ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOTHERAPY; DRUG THERAPY; ENZYME INHIBITION; HIGH PRESSURE LIQUID CHROMATOGRAPHY; KINETIC THEORY; MASS SPECTROMETRY; RESINS;

CAUSATIVE AGENTS; CHEMICAL LIBRARY; HIGH-THROUGHPUT SCREENING; SELECTIVE INHIBITORS;

THROUGHPUT;

BENZAMIDE; DIHYDROOROTATE DEHYDROGENASE; DIHYDROOROTATE DEHYDROGENASE INHIBITOR; NAPHTHALENE; UBIQUINONE;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG SCREENING; DRUG STRUCTURE; ENZYME BINDING; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; KINETICS; MASS SPECTROMETRY; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SCREENING TEST; SITE DIRECTED MUTAGENESIS;

ANIMALS; AUTOMATION; BINDING SITES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; KINETICS; MASS SPECTROMETRY; MITOCHONDRIA; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; PLASMODIUM FALCIPARUM; PROTEIN BINDING; TIME FACTORS; UBIQUINONE; UREA;

PLASMODIUM FALCIPARUM;

EID: 20444470318     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M501100200     Document Type: Article

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