Deoxyuridine triphosphate nucleotidohydrolase as a potential antiparasitic drug target

Journal of Medicinal Chemistry

Volumn 48, Issue 19, 2005, Pages 5942-5954

  Nguyen, Corinne ^a   Kasinathan, Ganasan ^a   Leal Cortijo, Isabel ^b   Musso Buendia, Alexander ^b   Kaiser, Marcel ^c   Brun, Reto ^c   Ruiz Pérez, Luis M ^b   Johansson, Nils G ^d   González Pacanowska, Dolores ^b   Gilbert, Ian H ^a,e  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

^c SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^d MEDIVIR AB   (Sweden)

^e UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5' O TRIPHENYLSILYL 2',3' DIDEHYDRO 2',3' DIDEOXYURIDINE; 5' TRITYLAMINO 2',5' DIDEOXYURIDINE; ANTIMALARIAL AGENT; ANTIPARASITIC AGENT; DEOXYURIDINE DERIVATIVE; DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE; UNCLASSIFIED DRUG; URIDINE DERIVATIVE;

ANIMAL CELL; ANIMAL TISSUE; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TARGETING; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME STRUCTURE; IN VITRO STUDY; INHIBITION KINETICS; LEISHMANIA MAJOR; NONHUMAN; PLASMODIUM FALCIPARUM; RAT; STRUCTURE ACTIVITY RELATION; VALIDATION PROCESS;

ANIMALS; ANTIMALARIALS; CELLS, CULTURED; DEOXYURIDINE; HUMANS; LEISHMANIA DONOVANI; MACROPHAGES, PERITONEAL; MICE; MYOBLASTS; PLASMODIUM FALCIPARUM; PYROPHOSPHATASES; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI RHODESIENSE; TRYPANOSOMA CRUZI;

EID: 24944499627     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050111e     Document Type: Article

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