Synthesis and structure-activity relationships of phosphonic arginine mimetics as inhibitors of the M1 and M17 aminopeptidases from plasmodium falciparum

Journal of Medicinal Chemistry

Volumn 56, Issue 12, 2013, Pages 5213-5217

  Kannan Sivaraman, Komagal ^a   Paiardini, Alessandro ^b   Sieńczyk, Marcin ^c   Ruggeri, Chiara ^b   Oellig, Christine A ^a   Dalton, John P ^d,e   Scammells, Peter J ^a   Drag, Marcin ^c,f   McGowan, Sheena ^a  

^a MONASH UNIVERSITY   (Australia)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c WROCLAW UNIVERSITY OF TECHNOLOGY   (Poland)

^d UNIVERSITY OF TECHNOLOGY SYDNEY   (Australia)

^e MCGILL UNIVERSITY   (Canada)

^f BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 GUANIDINOPHENYL); 3 GUANIDINOPHENYL; AMINOPEPTIDASE; ANTIMALARIAL AGENT; ARGININE DERIVATIVE; HOMOARGININE; PHOSPHONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; PARASITE; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION; SURVIVAL;

ANTIGENS, CD13; ARGININE; BIOMIMETIC MATERIALS; CATALYTIC DOMAIN; CHEMISTRY TECHNIQUES, SYNTHETIC; ENZYME INHIBITORS; MODELS, MOLECULAR; PHOSPHOROUS ACIDS; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84879558016     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm4005972     Document Type: Article

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