Crystal structure of the FK506 binding domain of Plasmodium falciparum FKBP35 in complex with FK506

Biochemistry

Volumn 47, Issue 22, 2008, Pages 5951-5961

  Kotaka, Masayo ^a   Ye, Hong ^a   Alag, Reema ^a   Hu, Guangan ^a   Bozdech, Zbynek ^a   Preiser, Peter Rainer ^a   Ho, Sup Yoon ^a   Lescar, Julien ^b  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^b Centre National de la Recherche Scientifique   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DISEASES; DRUG PRODUCTS; PROTEINS; YEAST;

PLASMODIUM FALCIPARUM; STRUCTURAL DIFFERENCES;

PROTOZOA;

CYCLOSPORIN A; CYSTEINE; DRUG ANALOG; FK 506 BINDING PROTEIN; FK 506 BINDING PROTEIN 35; HISTIDINE; ISOLEUCINE; SERINE; TACROLIMUS;

AMINO ACID SUBSTITUTION; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG DESIGN; DRUG MECHANISM; DRUG PROTEIN BINDING; HUMAN; LIGAND BINDING; MALARIA; MICROARRAY ANALYSIS; MULTIDRUG RESISTANCE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEOTIDE SEQUENCE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN DOMAIN; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIMALARIALS; BINDING SITES; CALCINEURIN; CRYSTALLOGRAPHY, X-RAY; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PLASMODIUM FALCIPARUM; PROTEIN STRUCTURE, TERTIARY; PROTOZOAN PROTEINS; TACROLIMUS; TACROLIMUS BINDING PROTEINS;

PLASMODIUM FALCIPARUM; PLASMODIUM PARASITES;

EID: 44449107714     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi800004u     Document Type: Article

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