β-Branched acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 7, 2011, Pages 2378-2391

  Baragaña, Beatriz ^a   McCarthy, Orla ^a   Sánchez, Paula ^b   Bosch Navarrete, Cristina ^b   Kaiser, Marcel ^c   Brun, Reto ^c   Whittingham, Jean L ^d   Roberts, Shirley M ^d   Zhou, Xiao Xiong ^e   Wilson, Keith S ^d   Johansson, Nils Gunnar ^e   González Pacanowska, Dolores ^b   Gilbert, Ian H ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

^c SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^d UNIVERSITY OF YORK   (United Kingdom)

^e MEDIVIR AB   (Sweden)

Author keywords

dUTPase; Plasmodium falciparum

Indexed keywords

1 (2 AMIDO 4 HYDROXYBUTYL)URACIL; 1 (2 AMIDO 4 TRITYLOXYBUTYL)URACIL; 1 (2 DIMETHYLAMIDO 4 HYDROXYBUTYL)URACIL; 1 (2 DIMETHYLAMIDO 4 TRITYLOXYBUTYL)URACIL; 1 (2 MORPHOLINAMIDO 4 HYDROXYBUTYL)URACIL; 1 (2 MORPHOLINAMIDO 4 TRITYLOXYBUTYL)URACIL; 1 [(2 OXOTETRAHYDROFURAN 3 YL)METHYL]URACIL; 1 [2 (ACETAMIDE) 4 (TERT BUTYLDIPHENYLSILYLOXY)BUTYL]URACIL; 1 [2 (CARBOETHOXYETHYLAMIDO) 4 TRITYLOXYBUTYL]URACIL; 1 [2 (CARBOXY) 4 (TERT BUTYLDIPHENYLSILYLOXY)BUTYL]URACIL; 1 [2 (CARBOXYETHYLAMIDO) 4 TRITYLOXYBUTYL]URACIL; 1 [2 (DIETHYLAMIDO) 4 (TERT BUTYLDIPHENYLSILYLOXY)BUTYL]URACIL; 1 [2 (ETHYLAMIDO) 4 (TERT BUTYLDIPHENYLSILYLOXY)BUTYL]URACIL; 1 [2 (METHOXYETHYLAMIDO) 4 HYDROXYBUTYL]URACIL; 1 [2 (METHOXYETHYLAMIDO) 4 TRITYLOXYBUTYL]URACIL; 1 [2 (METHYLAMIDO) 4 (TERT BUTYLDIPHENYLSILYLOXY)BUTYL]URACIL; 1 [2 (N METHYLPIPERAZINE)AMIDO 4 TRITYLOXYBUTYL]URACIL; 1 [2 (N,N DIMETHYLAMINOETHYLAMIDO) 4 HYDROXYBUTYL]URACIL; 1 [2 (N,N DIMETHYLAMINOETHYLAMIDO) 4 TRITYLOXYBUTYL]URACIL; 1 [2 (TERT BUTYLDIPHENYLSILYLOXYETHYLAMIDO) 4 HYDROXYBUTYL]URACIL; 1 [2 (TERT BUTYLDIPHENYLSILYLOXYETHYLAMIDO) 4 TRITYLOXYBUTYL]URACIL; ANTIMALARIAL AGENT; BETA BRANCHED ACYCLIC NUCLEOSIDE DERIVATIVE; BETA BRANCHED ACYCLIC URIDINE DERIVATIVE; CHLOROQUINE; DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE; DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE INHIBITOR; NUCLEOTIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; URACIL;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME STRUCTURE; GROWTH INHIBITION; NONHUMAN; NUCLEOTIDE METABOLISM; PLASMODIUM FALCIPARUM; RAT;

ANTIMALARIALS; DEOXYURIDINE; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; PLASMODIUM FALCIPARUM; PYROPHOSPHATASES; STRUCTURE-ACTIVITY RELATIONSHIP;

PLASMODIUM FALCIPARUM;

EID: 79953202128     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.02.012     Document Type: Article

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