Synthesis and biological evaluation of NAS-21 and NAS-91 analogues as potential inhibitors of the mycobacterial FAS-II dehydratase enzyme Rv0636

Microbiology

Volumn 154, Issue 7, 2008, Pages 1866-1875

  Bhowruth, Veemal ^a   Brown, Alistair K ^a   Besra, Gurdyal S ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 OXOACYL ACYL CARRIER PROTEIN SYNTHASE; CLOTRIMAZOLE; ECONAZOLE; FATTY ACID ESTER; FATTY ACID SYNTHASE; FATTY ACID SYNTHASE INHIBITOR; HYDROLYASE; MYCOLIC ACID; TUBERCULOSTATIC AGENT;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; CELL FREE SYSTEM; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; FATTY ACID SYNTHESIS; GENE OVEREXPRESSION; IC 50; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM BOVIS; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL;

ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; ENZYME INHIBITORS; FATTY ACID SYNTHETASE COMPLEX; FATTY ACID SYNTHETASE COMPLEX, TYPE II; FLAVONOIDS; HUMANS; MYCOBACTERIUM; MYCOBACTERIUM INFECTIONS; SMALL MOLECULE LIBRARIES;

MYCOBACTERIUM BOVIS BCG; MYCOBACTERIUM TUBERCULOSIS;

EID: 51149120354     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/mic.0.2008/017434-0     Document Type: Article

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