Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin

Cell Host and Microbe

Volumn 11, Issue 6, 2012, Pages 654-663

  Hoepfner, Dominic ^a   McNamara, Case W ^b   Lim, Chek Shik ^c   Studer, Christian ^a   Riedl, Ralph ^a   Aust, Thomas ^a   McCormack, Susan L ^b   Plouffe, David M ^b   Meister, Stephan ^d   Schuierer, Sven ^a   Plikat, Uwe ^a   Hartmann, Nicole ^a   Staedtler, Frank ^a   Cotesta, Simona ^a   Schmitt, Esther K ^a   Petersen, Frank ^a   Supek, Frantisek ^b   Glynne, Richard J ^b   Tallarico, John A ^e   Porter, Jeffrey A ^e   Fishman, Mark C ^e   Bodenreider, Christophe ^c   Diagana, Thierry T ^c   Movva, N Rao ^a   Winzeler, Elizabeth A ^b,d,f   more..

^a NOVARTIS PHARMA AG   (Switzerland)

^b GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^c NOVARTIS INSTITUTE FOR TROPICAL DISEASES   (Singapore)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

^e NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIMALARIAL AGENT; ASPERENTIN; ISOCOUMARIN DERIVATIVE; LYSINE TRANSFER RNA LIGASE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ANTIMALARIAL ACTIVITY; ARTICLE; ENZYME INHIBITION; GENE OVEREXPRESSION; IC 50; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; SACCHAROMYCES CEREVISIAE;

ANTIMALARIALS; CELL LINE; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; FUNGI; HUMANS; INHIBITORY CONCENTRATION 50; ISOCOUMARINS; LYSINE-TRNA LIGASE; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; PROTEIN BIOSYNTHESIS; PROTOZOAN PROTEINS;

EID: 84862286628     PISSN: 19313128     EISSN: 19346069     Source Type: Journal    
DOI: 10.1016/j.chom.2012.04.015     Document Type: Article

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