3,6-Diamino-4-(2-halophenyl)-2-benzoylthieno[2,3- b ]pyridine-5- carbonitriles are selective inhibitors of plasmodium falciparum glycogen synthase kinase-3

Journal of Medicinal Chemistry

Volumn 56, Issue 1, 2013, Pages 264-275

  Fugel, Wiebke ^a   Oberholzer, Anselm Erich ^b   Gschloessl, Bernhard ^c   Dzikowski, Ron ^d   Pressburger, Narkiss ^d   Preu, Lutz ^a   Pearl, Laurence H ^e   Baratte, Blandine ^f   Ratin, Morgane ^f   Okun, Ilya ^g   Doerig, Christian ^h   Kruggel, Sebastian ⁱ   Lemcke, Thomas ⁱ   Meijer, Laurent ^f,j   Kunick, Conrad ^a  

^a TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

^b Structural Biology Community Laenggasse (Sbcl)   (Switzerland)

^c CENTRE DE BIOLOGIE ET DE GESTION DES POPULATIONS   (France)

^d HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^e UNIVERSITY OF SUSSEX   (United Kingdom)

^f Protein Phosphorylation and Human Disease Group   (France)

^g CHEMDIV INC   (United States)

^h MONASH UNIVERSITY   (Australia)

ⁱ UNIVERSITY OF HAMBURG   (Germany)

^j ManRos Therapeutics   (France)

more..

Author keywords

[No Author keywords available]

Indexed keywords

3,6 DIAMINO 4 (2 HALOPHENYL) 2 BENZOYLTHIENO[2,3 B]PYRIDINE 5 CARBONITRILE DERIVATIVE; ANTIMALARIAL AGENT; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG IDENTIFICATION; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME SPECIFICITY; ERYTHROCYTE; HIGH THROUGHPUT SCREENING; HUMAN; IC 50; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; PLASMODIUM FALCIPARUM;

ADENOSINE TRIPHOSPHATE; ANTIMALARIALS; CRYSTALLOGRAPHY, X-RAY; GLYCOGEN SYNTHASE KINASE 3; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MOLECULAR DOCKING SIMULATION; NITRILES; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; PROTEIN BINDING; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 84872298847     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301575n     Document Type: Article

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