메뉴 건너뛰기




Volumn 35, Issue 4, 2011, Pages 609-619

Phosphoethanolamine methyltransferases in phosphocholine biosynthesis: Functions and potential for antiparasite therapy

Author keywords

Bioengineering; Methyltransferase; Phosphatidylcholine; Phosphocholine; S adenosyl l methionine; Therapy

Indexed keywords

AMODIAQUINE; CETRIMIDE; CHLOROQUINE; METHYLTRANSFERASE; MILTEFOSINE; PHOSPHATIDYLCHOLINE; PHOSPHOETHANOLAMINE; PHOSPHOETHANOLAMINE METHYLTRANSFERASE; PHOSPHORYLCHOLINE; QUINIDINE; QUININE; S ADENOSYLMETHIONINE; UNCLASSIFIED DRUG;

EID: 79958025884     PISSN: 01686445     EISSN: 15746976     Source Type: Journal    
DOI: 10.1111/j.1574-6976.2011.00267.x     Document Type: Article
Times cited : (34)

References (50)
  • 1
    • 76749096268 scopus 로고    scopus 로고
    • Targeting the lipid metabolic pathways for the treatment of malaria
    • Ben Mamoun C, Prigge ST & Vial H (2010) Targeting the lipid metabolic pathways for the treatment of malaria. Drug Develop Res 71: 44-55.
    • (2010) Drug Develop Res , vol.71 , pp. 44-55
    • Ben Mamoun, C.1    Prigge, S.T.2    Vial, H.3
  • 2
    • 77649288041 scopus 로고    scopus 로고
    • Identification of inhibitors of Plasmodium falciparum phosphoethanolamine methyltransferase using an enzyme-coupled transmethylation assay
    • Bobenchik AM, Choi JY, Mishra A et al. (2010) Identification of inhibitors of Plasmodium falciparum phosphoethanolamine methyltransferase using an enzyme-coupled transmethylation assay. BMC Biochem 11: 4.
    • (2010) BMC Biochem , vol.11 , pp. 4
    • Bobenchik, A.M.1    Choi, J.Y.2    Mishra, A.3
  • 3
    • 0034522758 scopus 로고    scopus 로고
    • The isolation and characterization in yeast of a gene for Arabidopsis S-adenosylmethionine:phospho-ethanolamine N-methyltransferase
    • Bolognese CP & McGraw P (2000) The isolation and characterization in yeast of a gene for Arabidopsis S-adenosylmethionine:phospho-ethanolamine N-methyltransferase. Plant Physiol 124: 1800-1813.
    • (2000) Plant Physiol , vol.124 , pp. 1800-1813
    • Bolognese, C.P.1    McGraw, P.2
  • 4
    • 34250782611 scopus 로고    scopus 로고
    • Phosphoethanolamine N-methyltransferase (PMT-1) catalyses the first reaction of a new pathway for phosphocholine biosynthesis in Caenorhabditis elegans
    • Brendza KM, Haakenson W, Cahoon RE et al. (2007) Phosphoethanolamine N-methyltransferase (PMT-1) catalyses the first reaction of a new pathway for phosphocholine biosynthesis in Caenorhabditis elegans. Biochem J 404: 439-448.
    • (2007) Biochem J , vol.404 , pp. 439-448
    • Brendza, K.M.1    Haakenson, W.2    Cahoon, R.E.3
  • 5
    • 0036000060 scopus 로고    scopus 로고
    • Molecular and biochemical characterization of a cold-regulated phosphoethanolamine N-methyltransferase from wheat
    • Charron JB, Breton G, Danyluk J, Muzac I, Ibrahim RK & Sarhan F (2002) Molecular and biochemical characterization of a cold-regulated phosphoethanolamine N-methyltransferase from wheat. Plant Physiol 129: 363-373.
    • (2002) Plant Physiol , vol.129 , pp. 363-373
    • Charron, J.B.1    Breton, G.2    Danyluk, J.3    Muzac, I.4    Ibrahim, R.K.5    Sarhan, F.6
  • 6
    • 0027338134 scopus 로고
    • Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-l-methionine
    • Cheng X, Kumar S, Posfai J, Pflugrath JW & Roberts RJ (1993) Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-l-methionine. Cell 74: 299-307.
    • (1993) Cell , vol.74 , pp. 299-307
    • Cheng, X.1    Kumar, S.2    Posfai, J.3    Pflugrath, J.W.4    Roberts, R.J.5
  • 7
    • 4043121846 scopus 로고    scopus 로고
    • The xipotl mutant of Arabidopsis reveals a critical role for phospholipid metabolism in root system development and epidermal cell integrity
    • Cruz-Ramirez A, Lopez-Bucio J, Ramirez-Pimentel G et al. (2004) The xipotl mutant of Arabidopsis reveals a critical role for phospholipid metabolism in root system development and epidermal cell integrity. Plant Cell 16: 2020-2034.
    • (2004) Plant Cell , vol.16 , pp. 2020-2034
    • Cruz-Ramirez, A.1    Lopez-Bucio, J.2    Ramirez-Pimentel, G.3
  • 8
    • 0000644791 scopus 로고
    • Phosphatidylcholine synthesis: differing patterns in soybean and carrot
    • Datko AH & Mudd SH (1988a) Phosphatidylcholine synthesis: differing patterns in soybean and carrot. Plant Physiol 88: 854-861.
    • (1988) Plant Physiol. , vol.88 , pp. 854-861
    • Datko, A.H.1    Mudd, S.H.2
  • 9
    • 0000416085 scopus 로고
    • Enzymes of phosphatidylcholine synthesis in Lemna, soybean, and carrot
    • Datko AH & Mudd SH (1988b) Enzymes of phosphatidylcholine synthesis in Lemna, soybean, and carrot. Plant Physiol 88: 1338-1348.
    • (1988) Plant Physiol , vol.88 , pp. 1338-1348
    • Datko, A.H.1    Mudd, S.H.2
  • 11
    • 0030908445 scopus 로고    scopus 로고
    • Phospholipid metabolism of serine in Plasmodium-infected erythrocytes involves phosphatidylserine and direct serine decarboxylation
    • Elabbadi N, Ancelin ML & Vial HJ (1997) Phospholipid metabolism of serine in Plasmodium-infected erythrocytes involves phosphatidylserine and direct serine decarboxylation. Biochem J 324: 435-445.
    • (1997) Biochem J , vol.324 , pp. 435-445
    • Elabbadi, N.1    Ancelin, M.L.2    Vial, H.J.3
  • 13
    • 0001166879 scopus 로고
    • C tracer evidence for synthesis of choline and betaine via phosphoryl base intermediates in salinized sugarbeet leaves
    • Hanson AD & Rhodes D (1983) C tracer evidence for synthesis of choline and betaine via phosphoryl base intermediates in salinized sugarbeet leaves. Plant Physiol 71: 692-700.
    • (1983) Plant Physiol , vol.71 , pp. 692-700
    • Hanson, A.D.1    Rhodes, D.2
  • 14
    • 0009861692 scopus 로고
    • Radiotracer evidence implicating phosphoryl and phosphatidyl bases as intermediates in betaine synthesis by water-stressed barley leaves
    • Hitz WH, Rhodes D & Hanson AD (1981) Radiotracer evidence implicating phosphoryl and phosphatidyl bases as intermediates in betaine synthesis by water-stressed barley leaves. Plant Physiol 68: 814-822.
    • (1981) Plant Physiol , vol.68 , pp. 814-822
    • Hitz, W.H.1    Rhodes, D.2    Hanson, A.D.3
  • 15
    • 0034812118 scopus 로고    scopus 로고
    • Two polymorphic forms of human histamine methyltransferase: structural, thermal, and kinetic comparisons
    • Horton JR, Sawada K, Nishibori M, Zhang X & Cheng X (2001) Two polymorphic forms of human histamine methyltransferase: structural, thermal, and kinetic comparisons. Structure 9: 837-849.
    • (2001) Structure. , vol.9 , pp. 837-849
    • Horton, J.R.1    Sawada, K.2    Nishibori, M.3    Zhang, X.4    Cheng, X.5
  • 16
    • 70450254992 scopus 로고    scopus 로고
    • Biochemical characterization of two wheat phosphoethanolamine N-methyltransferase isoforms with different sensitivities to inhibition by phosphatidic acid
    • Jost R, Berkowitz O, Shaw J & Masle J (2009) Biochemical characterization of two wheat phosphoethanolamine N-methyltransferase isoforms with different sensitivities to inhibition by phosphatidic acid. J Biol Chem 284: 31962-31971.
    • (2009) J Biol Chem , vol.284 , pp. 31962-31971
    • Jost, R.1    Berkowitz, O.2    Shaw, J.3    Masle, J.4
  • 17
    • 0028179364 scopus 로고
    • Widespread occurrence of three sequence motifs in diverse S-adenosylmethionine-dependent methyltransferases suggests a common structure for these enzymes
    • Kagan RM & Clarke S (1994) Widespread occurrence of three sequence motifs in diverse S-adenosylmethionine-dependent methyltransferases suggests a common structure for these enzymes. Arch Biochem Biophys 310: 417-427.
    • (1994) Arch Biochem Biophys , vol.310 , pp. 417-427
    • Kagan, R.M.1    Clarke, S.2
  • 18
    • 37849026460 scopus 로고    scopus 로고
    • Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus
    • Kanasaki K, Kanda Y, Palmsten K et al. (2008) Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus. Dev Biol 313: 584-593.
    • (2008) Dev Biol , vol.313 , pp. 584-593
    • Kanasaki, K.1    Kanda, Y.2    Palmsten, K.3
  • 19
    • 0000402167 scopus 로고
    • Oxidation of fatty acids and tricarboxylic acid cycle intermediates by isolated rat liver mitochondria
    • Kennedy EP & Lehninger AL (1949) Oxidation of fatty acids and tricarboxylic acid cycle intermediates by isolated rat liver mitochondria. J Biol Chem 179: 957-972.
    • (1949) J Biol Chem , vol.179 , pp. 957-972
    • Kennedy, E.P.1    Lehninger, A.L.2
  • 20
    • 0000749205 scopus 로고
    • The function of cytidine coenzymes in the biosynthesis of phospholipids
    • Kennedy EP & Weiss SB (1956) The function of cytidine coenzymes in the biosynthesis of phospholipids. J Biol Chem 222: 193-214.
    • (1956) J Biol Chem , vol.222 , pp. 193-214
    • Kennedy, E.P.1    Weiss, S.B.2
  • 21
    • 67650129378 scopus 로고    scopus 로고
    • Functional characterization of phospholipid N-methyltransferases from Arabidopsis and soybean
    • Keogh MR, Courtney PD, Kinney AJ & Dewey RE (2009) Functional characterization of phospholipid N-methyltransferases from Arabidopsis and soybean. J Biol Chem 284: 15439-15447.
    • (2009) J Biol Chem , vol.284 , pp. 15439-15447
    • Keogh, M.R.1    Courtney, P.D.2    Kinney, A.J.3    Dewey, R.E.4
  • 22
    • 0023656673 scopus 로고
    • Yeast phosphatidylethanolamine methylation pathway. Cloning and characterization of two distinct methyltransferase genes
    • Kodaki T & Yamashita S (1987) Yeast phosphatidylethanolamine methylation pathway. Cloning and characterization of two distinct methyltransferase genes. J Biol Chem 262: 15428-15435.
    • (1987) J Biol Chem , vol.262 , pp. 15428-15435
    • Kodaki, T.1    Yamashita, S.2
  • 23
    • 21344449339 scopus 로고    scopus 로고
    • Searching new targets for anthelmintic strategies: interference with glycosphingolipid biosynthesis and phosphorylcholine metabolism affects development of Caenorhabditis elegans
    • Lochnit G, Bongaarts R & Geyer R (2005) Searching new targets for anthelmintic strategies: interference with glycosphingolipid biosynthesis and phosphorylcholine metabolism affects development of Caenorhabditis elegans. Int J Parasitol 35: 911-923.
    • (2005) Int J Parasitol. , vol.35 , pp. 911-923
    • Lochnit, G.1    Bongaarts, R.2    Geyer, R.3
  • 24
    • 69249104598 scopus 로고    scopus 로고
    • Glycine N-methyltransferase and regulation of S-adenosylmethionine levels
    • Luka Z, Mudd SH & Wagner C (2009) Glycine N-methyltransferase and regulation of S-adenosylmethionine levels. J Biol Chem 284: 22507-22511.
    • (2009) J Biol Chem , vol.284 , pp. 22507-22511
    • Luka, Z.1    Mudd, S.H.2    Wagner, C.3
  • 25
    • 0036917889 scopus 로고    scopus 로고
    • SAM (dependent) I AM: the S-adenosylmethionine-dependent methyltransferase fold
    • Martin JL & McMillan FM (2002) SAM (dependent) I AM: the S-adenosylmethionine-dependent methyltransferase fold. Curr Opin Struc Biol 12: 783-793.
    • (2002) Curr Opin Struc Biol. , vol.12 , pp. 783-793
    • Martin, J.L.1    McMillan, F.M.2
  • 26
    • 0024676686 scopus 로고
    • Mutations in the Saccharomyces cerevisiae opi3 gene: effects on phospholipid methylation, growth and cross-pathway regulation of inositol synthesis
    • McGraw P & Henry SA (1989) Mutations in the Saccharomyces cerevisiae opi3 gene: effects on phospholipid methylation, growth and cross-pathway regulation of inositol synthesis. Genetics 122: 317-330.
    • (1989) Genetics. , vol.122 , pp. 317-330
    • McGraw, P.1    Henry, S.A.2
  • 27
    • 0033829610 scopus 로고    scopus 로고
    • Metabolic modeling identifies key constraints on an engineered glycine betaine synthesis pathway in tobacco
    • McNeil SD, Rhodes D, Russell BL, Nuccio ML, Shachar-Hill Y & Hanson AD (2000) Metabolic modeling identifies key constraints on an engineered glycine betaine synthesis pathway in tobacco. Plant Physiol 124: 153-162.
    • (2000) Plant Physiol , vol.124 , pp. 153-162
    • McNeil, S.D.1    Rhodes, D.2    Russell, B.L.3    Nuccio, M.L.4    Shachar-Hill, Y.5    Hanson, A.D.6
  • 28
    • 0035859834 scopus 로고    scopus 로고
    • Enhanced synthesis of choline and glycine betaine in transgenic tobacco plants that overexpress phosphoethanolamine N-methyltransferase
    • McNeil SD, Nuccio ML, Ziemak MJ & Hanson AD (2001) Enhanced synthesis of choline and glycine betaine in transgenic tobacco plants that overexpress phosphoethanolamine N-methyltransferase. P Natl Acad Sci USA 98: 10001-10005.
    • (2001) P Natl Acad Sci USA , vol.98 , pp. 10001-10005
    • McNeil, S.D.1    Nuccio, M.L.2    Ziemak, M.J.3    Hanson, A.D.4
  • 29
    • 0036741576 scopus 로고    scopus 로고
    • Silencing of phosphoethanolamine N-methyltransferase results in temperature-sensitive male sterility and salt hypersensitivity in Arabidopsis
    • Mou Z, Wang X, Fu Z et al. (2002) Silencing of phosphoethanolamine N-methyltransferase results in temperature-sensitive male sterility and salt hypersensitivity in Arabidopsis. Plant Cell 14: 2031-2043.
    • (2002) Plant Cell , vol.14 , pp. 2031-2043
    • Mou, Z.1    Wang, X.2    Fu, Z.3
  • 30
    • 0142097535 scopus 로고
    • Phosphoethanolamine bases as intermediates in phosphatidylcholine synthesis by Lemna
    • Mudd SH & Datko AH (1986) Phosphoethanolamine bases as intermediates in phosphatidylcholine synthesis by Lemna. Plant Physiol 82: 126-135.
    • (1986) Plant Physiol , vol.82 , pp. 126-135
    • Mudd, S.H.1    Datko, A.H.2
  • 31
    • 0013903523 scopus 로고
    • Enthalpy changes accompanying the transfer of a methyl group from S-adenosylmethionine and other sulfonium compounds to homocysteine
    • Mudd SH, Klee WA & Ross PD (1966) Enthalpy changes accompanying the transfer of a methyl group from S-adenosylmethionine and other sulfonium compounds to homocysteine. Biochemistry 5: 1653-1660.
    • (1966) Biochemistry , vol.5 , pp. 1653-1660
    • Mudd, S.H.1    Klee, W.A.2    Ross, P.D.3
  • 32
    • 0034640386 scopus 로고    scopus 로고
    • cDNA cloning of phosphoethanolamine N-methyltransferase from spinach by complementation in Schizosaccharomyces pombe and characterization of the recombinant enzyme
    • Nuccio ML, Ziemak MJ, Henry SA, Weretilnyk EA & Hanson AD (2000) cDNA cloning of phosphoethanolamine N-methyltransferase from spinach by complementation in Schizosaccharomyces pombe and characterization of the recombinant enzyme. J Biol Chem 275: 14095-14101.
    • (2000) J Biol Chem , vol.275 , pp. 14095-14101
    • Nuccio, M.L.1    Ziemak, M.J.2    Henry, S.A.3    Weretilnyk, E.A.4    Hanson, A.D.5
  • 33
    • 33646551822 scopus 로고    scopus 로고
    • Defining the role of phosphomethylethanolamine N-methyltransferase from Caenorhabditis elegans in phosphocholine biosynthesis by biochemical and kinetic analysis
    • Palavalli LH, Brendza KM, Haakenson W et al. (2006) Defining the role of phosphomethylethanolamine N-methyltransferase from Caenorhabditis elegans in phosphocholine biosynthesis by biochemical and kinetic analysis. Biochemistry 45: 6056-6065.
    • (2006) Biochemistry , vol.45 , pp. 6056-6065
    • Palavalli, L.H.1    Brendza, K.M.2    Haakenson, W.3
  • 35
    • 1942437433 scopus 로고    scopus 로고
    • A pathway for phosphatidylcholine biosynthesis in Plasmodium falciparum involving phosphoethanolamine methylation
    • Pessi G, Kociubinski G & Mamoun CB (2004) A pathway for phosphatidylcholine biosynthesis in Plasmodium falciparum involving phosphoethanolamine methylation. P Natl Acad Sci USA 101: 6206-6211.
    • (2004) P Natl Acad Sci USA , vol.101 , pp. 6206-6211
    • Pessi, G.1    Kociubinski, G.2    Mamoun, C.B.3
  • 36
    • 16844367110 scopus 로고    scopus 로고
    • In vivo evidence for the specificity of Plasmodium falciparum phosphoethanolamine methyltransferase and its coupling to the Kennedy pathway
    • Pessi G, Choi JY, Reynolds JM, Voelker DR & Mamoun CB (2005) In vivo evidence for the specificity of Plasmodium falciparum phosphoethanolamine methyltransferase and its coupling to the Kennedy pathway. J Biol Chem 280: 12461-12466.
    • (2005) J Biol Chem , vol.280 , pp. 12461-12466
    • Pessi, G.1    Choi, J.Y.2    Reynolds, J.M.3    Voelker, D.R.4    Mamoun, C.B.5
  • 37
    • 43149112081 scopus 로고    scopus 로고
    • Biochemical and genetic analysis of the phosphoethanolamine methyltransferase of the human malaria parasite Plasmodium falciparum
    • Reynolds JM, Takebe S, Choi JY et al. (2008) Biochemical and genetic analysis of the phosphoethanolamine methyltransferase of the human malaria parasite Plasmodium falciparum. J Biol Chem 283: 7894-7900.
    • (2008) J Biol Chem , vol.283 , pp. 7894-7900
    • Reynolds, J.M.1    Takebe, S.2    Choi, J.Y.3
  • 38
  • 39
    • 0034103848 scopus 로고    scopus 로고
    • Phosphocholine synthesis in spinach: characterization of phosphoethanolamine N-methyltransferase
    • Smith D, Summers P & Weretilnky E (2000) Phosphocholine synthesis in spinach: characterization of phosphoethanolamine N-methyltransferase. Physiol Plantarum 108: 286-294.
    • (2000) Physiol Plantarum. , vol.108 , pp. 286-294
    • Smith, D.1    Summers, P.2    Weretilnky, E.3
  • 40
    • 0024256676 scopus 로고
    • Saccharomyces cerevisiae cho2 mutants are deficient in phospholipid methylation and cross-pathway regulation of inositol synthesis
    • Summers EF, Letts VA, McGraw P & Henry SA (1988) Saccharomyces cerevisiae cho2 mutants are deficient in phospholipid methylation and cross-pathway regulation of inositol synthesis. Genetics 120: 909-922.
    • (1988) Genetics , vol.120 , pp. 909-922
    • Summers, E.F.1    Letts, V.A.2    McGraw, P.3    Henry, S.A.4
  • 41
    • 0027130367 scopus 로고
    • Choline synthesis in spinach in relation to salt stress
    • Summers PS & Weretilnyk EA (1993) Choline synthesis in spinach in relation to salt stress. Plant Physiol 103: 1269-1276.
    • (1993) Plant Physiol , vol.103 , pp. 1269-1276
    • Summers, P.S.1    Weretilnyk, E.A.2
  • 42
    • 17144403500 scopus 로고    scopus 로고
    • Similar regulation patterns of choline monooxygenase, phosphoethanolamine N-methyltransferase and S-adenosyl-l-methionine synthetase in leaves of the halophyte Atriplex nummularia L
    • Tabuchi T, Kawaguchi Y, Azuma T, Nanmori T & Yasuda T (2005) Similar regulation patterns of choline monooxygenase, phosphoethanolamine N-methyltransferase and S-adenosyl-l-methionine synthetase in leaves of the halophyte Atriplex nummularia L. Plant Cell Physiol 46: 505-513.
    • (2005) Plant Cell Physiol , vol.46 , pp. 505-513
    • Tabuchi, T.1    Kawaguchi, Y.2    Azuma, T.3    Nanmori, T.4    Yasuda, T.5
  • 43
    • 0024257603 scopus 로고
    • The methylation of phosphatidylethanolamine
    • Vance DE & Ridgway ND (1988) The methylation of phosphatidylethanolamine. Prog Lipid Res 27: 61-79.
    • (1988) Prog Lipid Res , vol.27 , pp. 61-79
    • Vance, D.E.1    Ridgway, N.D.2
  • 44
    • 0032538421 scopus 로고    scopus 로고
    • Biochemical and evolutionary significance of phospholipid methylation
    • Walkey CJ, Yu L, Agellon LB & Vance DE (1998) Biochemical and evolutionary significance of phospholipid methylation. J Biol Chem 273: 27043-27046.
    • (1998) J Biol Chem , vol.273 , pp. 27043-27046
    • Walkey, C.J.1    Yu, L.2    Agellon, L.B.3    Vance, D.E.4
  • 45
    • 0029176175 scopus 로고
    • Enzymes of choline synthesis in spinach (response of phospho-base N-methyltransferase activities to light and salinity)
    • Weretilnyk EA, Smith DD, Wilch GA & Summers PS (1995) Enzymes of choline synthesis in spinach (response of phospho-base N-methyltransferase activities to light and salinity). Plant Physiol 109: 1085-1091.
    • (1995) Plant Physiol , vol.109 , pp. 1085-1091
    • Weretilnyk, E.A.1    Smith, D.D.2    Wilch, G.A.3    Summers, P.S.4
  • 46
    • 34748897098 scopus 로고    scopus 로고
    • Choline induces transcriptional repression and proteasomal degradation of the malarial phosphoethanolamine methyltransferase
    • Witola WH & Ben Mamoun C (2007) Choline induces transcriptional repression and proteasomal degradation of the malarial phosphoethanolamine methyltransferase. Eukaryot Cell 6: 1618-1624.
    • (2007) Eukaryot Cell , vol.6 , pp. 1618-1624
    • Witola, W.H.1    Ben Mamoun, C.2
  • 47
    • 33746328378 scopus 로고    scopus 로고
    • Localization of the phosphoethanolamine methyltransferase of the human malaria parasite Plasmodium falciparum to the Golgi apparatus
    • Witola WH, Pessi G, El Bissati K, Reynolds JM & Mamoun CB (2006) Localization of the phosphoethanolamine methyltransferase of the human malaria parasite Plasmodium falciparum to the Golgi apparatus. J Biol Chem 281: 21305-21311.
    • (2006) J Biol Chem , vol.281 , pp. 21305-21311
    • Witola, W.H.1    Pessi, G.2    El Bissati, K.3    Reynolds, J.M.4    Mamoun, C.B.5
  • 48
    • 55549143016 scopus 로고    scopus 로고
    • Disruption of the Plasmodium falciparum PfPMT gene results in a complete loss of phosphatidylcholine biosynthesis via the serine-decarboxylase-phosphoethanolamine-methyltransferase pathway and severe growth and survival defects
    • Witola WH, El Bissati K, Pessi G, Xie C, Roepe PD & Mamoun CB (2008) Disruption of the Plasmodium falciparum PfPMT gene results in a complete loss of phosphatidylcholine biosynthesis via the serine-decarboxylase-phosphoethanolamine-methyltransferase pathway and severe growth and survival defects. J Biol Chem 283: 27636-27643.
    • (2008) J Biol Chem , vol.283 , pp. 27636-27643
    • Witola, W.H.1    El Bissati, K.2    Pessi, G.3    Xie, C.4    Roepe, P.D.5    Mamoun, C.B.6
  • 49
    • 35848937540 scopus 로고    scopus 로고
    • Cloning, characterization, and transformation of the phosphoethanolamine N-methyltransferase gene (ZmPEAMT1) in maize (Zea mays L.)
    • Wu S, Yu Z, Wang F et al. (2007) Cloning, characterization, and transformation of the phosphoethanolamine N-methyltransferase gene (ZmPEAMT1) in maize (Zea mays L.). Mol Biotechnol 36: 102-112.
    • (2007) Mol Biotechnol , vol.36 , pp. 102-112
    • Wu, S.1    Yu, Z.2    Wang, F.3
  • 50
    • 33645217524 scopus 로고    scopus 로고
    • Cloning, sequencing and salt induced expression of PEAMT and BADH in oilseed rape (Brassica napus)
    • Ye C, Wu S, Yang Q, Ma C, Yang G & Wang B (2005) Cloning, sequencing and salt induced expression of PEAMT and BADH in oilseed rape (Brassica napus). DNA Sequence 16: 364-371.
    • (2005) DNA Sequence , vol.16 , pp. 364-371
    • Ye, C.1    Wu, S.2    Yang, Q.3    Ma, C.4    Yang, G.5    Wang, B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.