Structural basis for the efficient phosphorylation of AZT-MP (3′-azido-3′-deoxythymidine monophosphate) and dGMP by Plasmodium falciparum type I thymidylate kinase

Biochemical Journal

Volumn 428, Issue 3, 2010, Pages 499-509

  Whittingham, Jean L ^a   Carrero Lerida, Juana ^b   Brannigan, James A ^a   Ruiz Perez, Luis M ^b   Silva, Ana P G ^a   Fogg, Mark J ^a   Wilkinson, Anthony J ^a   Gilbert, Ian H ^c   Wilson, Keith S ^a   González Pacanowska, Dolores ^b  

^a UNIVERSITY OF YORK   (United Kingdom)

^b INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Drug target; Ligand complex; Malaria; Plasmodium falciparum; Thymidylate kinase (TMPK)

Indexed keywords

BINARY COMPLEXES; CAUSATIVE AGENTS; DRUG TARGETS; E. COLI; HUMAN ENZYMES; LIGAND COMPLEXES; MONOPHOSPHATES; PHOSPHATE TRANSFER; PLASMODIUM FALCIPARUM; PRODRUG ACTIVATION; RATIONAL DESIGN; STRUCTURAL BASIS; STRUCTURAL INFORMATION; SUBSTRATE SPECIFICITY; TERNARY COMPLEX; THERAPEUTIC POTENTIALS; TRANSITION STATE; TRANSITION-STATE ANALOGUES; TYPE II;

CHEMICAL ACTIVATION; COMPLEXATION; ESCHERICHIA COLI; LIGANDS; PHOSPHORYLATION; TARGETS;

ENZYMES;

3' AZIDO 3' DEOXYTHYMIDINE MONOPHOSPHATE; AZIDE; GUANOSINE PHOSPHATE; PLASMODIUM FALCIPARUM TYPE I THYMIDYLATE KINASE; PROTOZOAL PROTEIN; THYMIDINE PHOSPHATE; UNCLASSIFIED DRUG; 2'-DEOXYGUANOSINE 5'-PHOSPHATE; 3' AZIDO 3' DEOXYTHYMIDINE 5'PHOSPHATE; 3'-AZIDO-3'-DEOXYTHYMIDINE 5'PHOSPHATE; DEOXYGUANOSINE PHOSPHATE; DIDEOXYNUCLEOTIDE; DRUG DERIVATIVE; NUCLEOSIDE MONOPHOSPHATE KINASE; PYRIMIDINE NUCLEOTIDE; THYMIDYLATE KINASE; ZIDOVUDINE;

AMINO ACID SEQUENCE; ARTICLE; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME SUBSTRATE; EUKARYOTE; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN TERTIARY STRUCTURE; CHEMISTRY; ENZYMOLOGY; KINETICS; METABOLISM; PHOSPHORYLATION;

ESCHERICHIA COLI; EUKARYOTA; PLASMODIUM (APICOMPLEXA); PLASMODIUM FALCIPARUM;

DEOXYGUANINE NUCLEOTIDES; DIDEOXYNUCLEOTIDES; KINETICS; NUCLEOSIDE-PHOSPHATE KINASE; PHOSPHORYLATION; PLASMODIUM FALCIPARUM; SUBSTRATE SPECIFICITY; THYMINE NUCLEOTIDES; ZIDOVUDINE;

EID: 77954911479     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20091880     Document Type: Article

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