Structure-activity relationships and blood distribution of antiplasmodial aminopeptidase-1 inhibitors

Journal of Medicinal Chemistry

Volumn 55, Issue 24, 2012, Pages 10909-10917

  Deprez Poulain, Rebecca ^a,b,c   Flipo, Marion ^a,b,c   Piveteau, Catherine ^a,b,c   Leroux, Florence ^a,b,c   Dassonneville, Sandrine ^a,b,c   Florent, Isabelle ^d   Maes, Louis ^e   Cos, Paul ^e   Deprez, Benoit ^a,b,c  

^a UNIV LILLE   (France)

^b INSTITUT PASTEUR DE LILLE   (France)

^c PRIM   (France)

^d MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

^e UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

2 BENZYL N (2 FLUOROBENZYL) N' HYDROXYMALONAMIDE; 2 BENZYL N (3 FLUOROBENZYL) N' HYDROXYMALONAMIDE; 2 BENZYL N (4 FLUOROBENZYL) N' HYDROXY 2 METHYLMALONAMIDE; 2 BENZYL N (4 FLUOROBENZYL) N' HYDROXYMALONAMIDE; 2 BENZYL N HYDROXY N' PYRIDIN 4 YLMETHYLMALONAMIDE; 2 BENZYLIDENE N HYDROXY N' PYRIDIN 4 YLMETHYLMALONAMIDE; 2,N BIS(4 FLUOROBENZYL) N' HYDROXYMALONAMIDE; 2,N DIBENZYL N' HYDROXYMALONAMIDE; AMINOPEPTIDASE 1 INHIBITOR; ANTIMALARIAL AGENT; ENZYME INHIBITOR; GLUTATHIONE; HALOGEN; HYDROXAMIC ACID; N (4 FLUOROBENZYL) 2 [1 (4 FLUOROPHENYL)METHYLIDENE] N' HYDROXYMALONAMIDE; N (4 FLUOROBENZYL) N' HYDROXY 2 (1 PHENYLMETHYLIDENE)MALONAMIDE; N BENZYL 2 [1 (4 FLUOROPHENYL)METHYLIDENE] N' HYDROXYMALONAMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; CATALYSIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DRUG DISTRIBUTION; DRUG POTENCY; DRUG SYNTHESIS; GROWTH INHIBITION; IN VITRO STUDY; IN VIVO STUDY; MICROSOME; MOLECULAR DOCKING; MOUSE; NONHUMAN; PLASMODIUM BERGHEI INFECTION; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION;

AMINOPEPTIDASES; ANIMALS; ANTIMALARIALS; CELL LINE; DRUG RESISTANCE; FEMALE; HUMANS; MALARIA; MALONATES; METALLOPROTEASES; MICE; MOLECULAR DOCKING SIMULATION; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PROTEIN BINDING; PROTOZOAN PROTEINS; RATS; SOLUBILITY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION; ZINC;

EID: 84871655128     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301506h     Document Type: Article

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