Factors influencing the specificity of inhibitor binding to the human and malaria parasite dihydroorotate dehydrogenases.

Journal of medicinal chemistry

Volumn 55, Issue 12, 2012, Pages 5841-5850

  Bedingfield, Paul T P ^a   Cowen, Deborah ^b   Acklam, Paul ^b   Cunningham, Fraser ^b   Parsons, Mark R ^b   McConkey, Glenn A ^b   Fishwick, Colin W G ^b   Johnson, A Peter ^b  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROOROTATE DEHYDROGENASE; ENZYME INHIBITOR; LIGAND; OXIDOREDUCTASE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG SCREENING; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; HUMAN; IC 50; MALARIA; METABOLISM; MOLECULAR LIBRARY; PARASITOLOGY; PLASMODIUM FALCIPARUM; PROTEIN CONFORMATION; SITE DIRECTED MUTAGENESIS;

DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; LIGANDS; MALARIA; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; PLASMODIUM FALCIPARUM; PROTEIN CONFORMATION; SMALL MOLECULE LIBRARIES; SUBSTRATE SPECIFICITY;

EID: 84865808746     PISSN: None     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300157n     Document Type: Article

References (0)