-
1
-
-
84875728618
-
Human infections and detection of Plasmodium knowlesi
-
Singh, B. & Daneshvar, C. Human infections and detection of Plasmodium knowlesi. Clin. Microbiol. Rev. 26, 165-184 (2013).
-
(2013)
Clin. Microbiol. Rev.
, vol.26
, pp. 165-184
-
-
Singh, B.1
Daneshvar, C.2
-
2
-
-
85081457020
-
-
World Health Organization. World Malaria Report 2012. [online]
-
World Health Organization. World Malaria Report 2012. [online] http://www.who.int/malaria/publications/world-malaria-report-2012/en/(WHO, 2012).
-
-
-
-
3
-
-
84856679687
-
Global malaria mortality between 1980and 2010: A systematic analysis
-
Murray, C. J. et al. Global malaria mortality between 1980 and 2010: a systematic analysis. Lancet 379, 413-431 (2012)
-
(2012)
Lancet
, vol.379
, pp. 413-431
-
-
Murray, C.J.1
-
4
-
-
0000197885
-
The hemolytic effect of primaquine and related compounds: A review
-
Beutler, E. The hemolytic effect of primaquine and related compounds: a review. Blood 14, 103-139 (1959).
-
(1959)
Blood
, vol.14
, pp. 103-139
-
-
Beutler, E.1
-
5
-
-
77956544478
-
The international limits and population at risk of Plasmodium vivax transmission in 2009
-
Guerra, C. A. et al. The international limits and population at risk of Plasmodium vivax transmission in 2009. PLoS Negl. Trop. Dis. 4, e774 (2010).
-
(2010)
PLoS Negl. Trop. Dis.
, vol.4
-
-
Guerra, C.A.1
-
7
-
-
77952382039
-
That was then but this is now: Malaria research in the time of an eradication agenda
-
Kappe, S. H., Vaughan, A. M., Boddey, J. A. & Cowman, A. F. That was then but this is now: malaria research in the time of an eradication agenda. Science 328, 862-866 (2010).
-
(2010)
Science
, vol.328
, pp. 862-866
-
-
Kappe, S.H.1
Vaughan, A.M.2
Boddey, J.A.3
Cowman, A.F.4
-
8
-
-
79957703902
-
A research agenda for malaria eradication: Drugs
-
Alonso, P. et al. A research agenda for malaria eradication: drugs. PLoS Med. 8, e1000402 (2011).
-
(2011)
PLoS Med.
, vol.8
-
-
Alonso, P.1
-
9
-
-
84878506144
-
Designing the next generation of medicines for malaria control and eradication
-
Burrows, J. N., Hooft van Huijsduijnen, R., Mohrle, J. J., Oeuvray, C. & Wells, T. N. Designing the next generation of medicines for malaria control and eradication. Malar. J. 12, 187 (2013).
-
(2013)
Malar. J.
, vol.12
, pp. 187
-
-
Burrows, J.N.1
Hooft Van Huijsduijnen, R.2
Mohrle, J.J.3
Oeuvray, C.4
Wells, T.N.5
-
10
-
-
80054715187
-
A high-throughput assay for the identification of drugs against late-stage Plasmodium falciparum gametocytes
-
Peatey, C. L., Spicer, T. P., Hodder, P. S., Trenholme, K. R. & Gardiner, D. L. A high-throughput assay for the identification of drugs against late-stage Plasmodium falciparum gametocytes. Mol. Biochem. Parasitol. 180, 127-131 (2011).
-
(2011)
Mol. Biochem. Parasitol
, vol.180
, pp. 127-131
-
-
Peatey, C.L.1
Spicer, T.P.2
Hodder, P.S.3
Trenholme, K.R.4
Gardiner, D.L.5
-
11
-
-
79953322662
-
Towards an in vitro model of Plasmodium hypnozoites suitable for drug discovery
-
Dembele, L. et al. Towards an in vitro model of Plasmodium hypnozoites suitable for drug discovery. PLoS ONE 6, e18162 (2011)
-
(2011)
PLoS ONE
, vol.6
-
-
Dembele, L.1
-
12
-
-
79955017122
-
A high-throughput screen targeting malaria transmission stages opens new avenues for drug development
-
Buchholz, K. et al. A high-throughput screen targeting malaria transmission stages opens new avenues for drug development. J. Infect. Dis. 203, 1445-1453 (2011).
-
(2011)
J. Infect. Dis.
, vol.203
, pp. 1445-1453
-
-
Buchholz, K.1
-
13
-
-
79953868333
-
A malaria gametocytocidal assay using oxidoreduction indicator, alamarBlue
-
Tanaka, T. Q. & Williamson, K. C. A malaria gametocytocidal assay using oxidoreduction indicator, alamarBlue. Mol. Biochem. Parasitol. 177, 160-163 (2011).
-
(2011)
Mol. Biochem. Parasitol.
, vol.177
, pp. 160-163
-
-
Tanaka, T.Q.1
Williamson, K.C.2
-
14
-
-
84871102282
-
Whole-cell in vitro screening for gametocytocidal compounds
-
Lucantoni, L. & Avery, V. Whole-cell in vitro screening for gametocytocidal compounds. Future Med. Chem. 4, 2337-2360 (2012).
-
(2012)
Future Med. Chem.
, vol.4
, pp. 2337-2360
-
-
Lucantoni, L.1
Avery, V.2
-
15
-
-
80053494971
-
The next opportunity in anti-malaria drug discovery: The liver stage
-
Derbyshire, E. R., Mota, M. M. & Clardy, J. The next opportunity in anti-malaria drug discovery: the liver stage. PLoS Pathog. 7, e1002178 (2011).
-
(2011)
PLoS Pathog
, vol.7
-
-
Derbyshire, E.R.1
Mota, M.M.2
Clardy, J.3
-
16
-
-
79959929769
-
How were new medicines discovered? Nature Rev
-
Swinney, D. C. & Anthony, J. How were new medicines discovered? Nature Rev. Drug Discov. 10, 507-519 (2011).
-
(2011)
Drug Discov.
, vol.10
, pp. 507-519
-
-
Swinney, D.C.1
Anthony, J.2
-
17
-
-
79952131874
-
Impact of high-throughput screening in biomedical research
-
Macarron, R. et al. Impact of high-throughput screening in biomedical research. Nature Rev. Drug Discov. 10, 188-195 (2011).
-
(2011)
Nature Rev. Drug Discov.
, vol.10
, pp. 188-195
-
-
MacArron, R.1
-
18
-
-
77952704258
-
Thousands of chemical starting points for antimalarial lead identification
-
Gamo, F. J. et al. Thousands of chemical starting points for antimalarial lead identification. Nature 465, 305-310 (2010).
-
(2010)
Nature
, vol.465
, pp. 305-310
-
-
Gamo, F.J.1
-
19
-
-
77952718950
-
Chemical genetics of Plasmodium falciparum
-
Guiguemde, W. A. et al. Chemical genetics of Plasmodium falciparum. Nature 465, 311-315 (2010).
-
(2010)
Nature
, vol.465
, pp. 311-315
-
-
Guiguemde, W.A.1
-
20
-
-
48249095940
-
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen
-
Plouffe, D. et al. In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. Proc. Natl Acad. Sci. USA 105, 9059-9064 (2008)
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 9059-9064
-
-
Plouffe, D.1
-
21
-
-
2142640849
-
Simple and Inexpensive Fluorescence-Based Technique for High-Throughput Antimalarial Drug Screening
-
DOI 10.1128/AAC.48.5.1803-1806.2004
-
Smilkstein, M. Sriwilaijaroen, N., Kelly, J. X., Wilairat, P. & Riscoe, M. Simple and inexpensive fluorescence-based technique for high-throughput antimalarial drug screening. Antimicrob. Agents Chemother. 48, 1803-1806 (2004). (Pubitemid 38544392)
-
(2004)
Antimicrobial Agents and Chemotherapy
, vol.48
, Issue.5
, pp. 1803-1806
-
-
Smilkstein, M.1
Sriwilaijaroen, N.2
Kelly, J.X.3
Wilairat, P.4
Riscoe, M.5
-
22
-
-
84856367163
-
Global phenotypic screening for antimalarials
-
Guiguemde, W. A. et al. Global phenotypic screening for antimalarials. Chem. Biol. 19, 116-129 (2012).
-
(2012)
Chem. Biol.
, vol.19
, pp. 116-129
-
-
Guiguemde, W.A.1
-
23
-
-
77954745330
-
Spirotetrahydro ?-carbolines (spiroindolones): A new class of potent and orally efficacious compounds for the treatment of malaria
-
Yeung, B. K. et al. Spirotetrahydro ?-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria. J. Med. Chem. 53, 5155-5164 (2010).
-
(2010)
J. Med. Chem.
, vol.53
, pp. 5155-5164
-
-
Yeung, B.K.1
-
24
-
-
77956280420
-
Spiroindolones, a potent compound class for the treatment of malaria
-
Rottmann, M. et al. Spiroindolones, a potent compound class for the treatment of malaria. Science 329, 1175-1180 (2010)
-
(2010)
Science
, vol.329
, pp. 1175-1180
-
-
Rottmann, M.1
-
25
-
-
84862571445
-
The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks Plasmodium falciparum transmission to anopheles mosquito vector
-
van Pelt-Koops, J. C. et al. The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks Plasmodium falciparum transmission to anopheles mosquito vector. Antimicrob. Agents Chemother. 56, 3544-3548 (2012).
-
(2012)
Antimicrob. Agents Chemother
, vol.56
, pp. 3544-3548
-
-
Van Pelt-Koops, J.C.1
-
26
-
-
84873901917
-
Na+ regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials
-
Spillman, N. J. et al. Na+ regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials. Cell Host Microbe 13, 227-237 (2013).
-
(2013)
Cell Host Microbe
, vol.13
, pp. 227-237
-
-
Spillman, N.J.1
-
27
-
-
78049482164
-
Antimalarial drugs: Speeding to a new lead
-
Tse, M. T. Antimalarial drugs: speeding to a new lead. Nature Rev. Drug Discov. 9, 842 (2010).
-
(2010)
Nature Rev. Drug Discov.
, vol.9
, pp. 842
-
-
Tse, M.T.1
-
28
-
-
80054735856
-
An invitation to open innovation in malaria drug discovery: 47 quality starting points from the TCAMS
-
Calderon, F. et al. An invitation to open innovation in malaria drug discovery: 47 quality starting points from the TCAMS. ACS Med. Chem. Lett. 2, 741-746 (2011).
-
(2011)
ACS Med. Chem. Lett.
, vol.2
, pp. 741-746
-
-
Calderon, F.1
-
29
-
-
84861086281
-
A divergent SAR study allows optimization of a potent 5-HT2c inhibitor to a promising antimalarial scaffold
-
Calderon, F. et al. A divergent SAR study allows optimization of a potent 5-HT2c inhibitor to a promising antimalarial scaffold. ACS Med. Chem. Lett. 3, 373-377 (2012).
-
(2012)
ACS Med. Chem. Lett.
, vol.3
, pp. 373-377
-
-
Calderon, F.1
-
30
-
-
80955160706
-
Cyclopropyl carboxamides: A new oral antimalarial series derived from the Tres Cantos Anti-Malarial Set (TCAMS)
-
Rueda, L. et al. Cyclopropyl carboxamides: A new oral antimalarial series derived from the Tres Cantos Anti-Malarial Set (TCAMS). ACS Med. Chem. Lett. 2, 840-844 (2011).
-
(2011)
ACS Med. Chem. Lett.
, vol.2
, pp. 840-844
-
-
Rueda, L.1
-
31
-
-
81555221105
-
Cyclopropyl carboxamides, a chemically novel class of antimalarial agents identified in a phenotypic screen
-
Sanz, L. M. et al. Cyclopropyl carboxamides, a chemically novel class of antimalarial agents identified in a phenotypic screen. Antimicrob. Agents Chemother. 55, 5740-5745 (2011).
-
(2011)
Antimicrob. Agents Chemother.
, vol.55
, pp. 5740-5745
-
-
Sanz, L.M.1
-
32
-
-
79958010723
-
The design and application of target-focused compound libraries
-
Harris, C. J., Hill, R. D., Sheppard, D. W., Slater, M. J. & Stouten, P. F. The design and application of target-focused compound libraries. Comb. Chem. High Throughput Screen. 14, 521-531 (2011).
-
(2011)
Comb. Chem. High Throughput Screen.
, vol.14
, pp. 521-531
-
-
Harris, C.J.1
Hill, R.D.2
Sheppard, D.W.3
Slater, M.J.4
Stouten, P.F.5
-
33
-
-
84855645204
-
Development and optimization of a novel 384-well anti-malarial imaging assay validated for high-throughput screening
-
Duffy, S. & Avery, V. M. Development and optimization of a novel 384-well anti-malarial imaging assay validated for high-throughput screening. Am. J. Trop. Med. Hyg. 86, 84-92 (2012).
-
(2012)
Am. J. Trop. Med. Hyg.
, vol.86
, pp. 84-92
-
-
Duffy, S.1
Avery, V.M.2
-
34
-
-
84859798468
-
3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential
-
Younis, Y. et al. 3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential. J. Med. Chem. 55, 3479-3487 (2012)
-
(2012)
J. Med. Chem.
, vol.55
, pp. 3479-3487
-
-
Younis, Y.1
-
35
-
-
84872040862
-
A class of tricyclic compounds blocking malaria parasite oocyst development and transmission
-
Eastman, R. T. et al. A class of tricyclic compounds blocking malaria parasite oocyst development and transmission. Antimicrob. Agents Chemother. 57, 425-435 (2013).
-
(2013)
Antimicrob. Agents Chemother
, vol.57
, pp. 425-435
-
-
Eastman, R.T.1
-
36
-
-
0023353173
-
Study on the treatment of Plasmodium cynomolgi infections of the macaque with ketotifen
-
Huang, W., Luo, M., Zhou, M. & Pan, X. Study on the treatment of Plasmodium cynomolgi infections of the macaque with ketotifen. Acta Pharmaceut. Sin. 22, 409 (1987).
-
(1987)
Acta Pharmaceut. Sin.
, vol.22
, pp. 409
-
-
Huang, W.1
Luo, M.2
Zhou, M.3
Pan, X.4
-
37
-
-
0032812617
-
Inhibition of the development of the hepatic stages of Plasmodium yoelii nigeriensis by antihistaminic agents
-
Singh, N. & Puri, S. Inhibition of the development of the hepatic stages of Plasmodium yoelii nigeriensis by antihistaminic agents. Ann. Trop. Med. Parasitol. 93, 419 (1999).
-
(1999)
Ann. Trop. Med. Parasitol
, vol.93
, pp. 419
-
-
Singh, N.1
Puri, S.2
-
38
-
-
84862820224
-
Ketotifen is an antimalarial prodrug of norketotifen with blood schizonticidal and liver-stage efficacy
-
Milner, E. et al. Ketotifen is an antimalarial prodrug of norketotifen with blood schizonticidal and liver-stage efficacy. Eur. J. Drug Metab. Pharmacokinet. 37, 17-22 (2012).
-
(2012)
Eur. J. Drug Metab. Pharmacokinet
, vol.37
, pp. 17-22
-
-
Milner, E.1
-
39
-
-
70350784153
-
A pre-emptive strike against malaria's stealthy hepatic forms
-
Mazier, D., Renia, L. & Snounou, G. A pre-emptive strike against malaria's stealthy hepatic forms. Nature Rev. Drug Discov. 8, 854-864 (2009).
-
(2009)
Nature Rev. Drug Discov.
, vol.8
, pp. 854-864
-
-
Mazier, D.1
Renia, L.2
Snounou, G.3
-
40
-
-
33845910913
-
A plant-derived morphinan as a novel lead compound active against malaria liver stages
-
Carraz, M.l. et al. A plant-derived morphinan as a novel lead compound active against malaria liver stages. PLoS Med. 3, e513 (2006).
-
(2006)
PLoS Med.
, vol.3
-
-
Carraz, M.L.1
-
41
-
-
83255176722
-
Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery
-
Meister, S. et al. Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science 334, 1372-1377 (2011)
-
(2011)
Science
, vol.334
, pp. 1372-1377
-
-
Meister, S.1
-
42
-
-
84861054503
-
Imidazolopiperazines: Lead optimization of the second-generation antimalarial agents
-
Nagle, A. et al. Imidazolopiperazines: lead optimization of the second-generation antimalarial agents. J. Med. Chem. 55, 4244-4273 (2012).
-
(2012)
J. Med. Chem.
, vol.55
, pp. 4244-4273
-
-
Nagle, A.1
-
43
-
-
79960645150
-
Imidazolopiperazines: Hit to lead optimization of new antimalarial agents
-
Wu, T. et al. Imidazolopiperazines: hit to lead optimization of new antimalarial agents. J. Med. Chem. 54, 5116-5130 (2011).
-
(2011)
J. Med. Chem.
, vol.54
, pp. 5116-5130
-
-
Wu, T.1
-
44
-
-
84861904136
-
Liver-stage malaria parasites vulnerable to diverse chemical scaffolds
-
Derbyshire, E. R., Prudencio, M., Mota, M. M. & Clardy, J. Liver-stage malaria parasites vulnerable to diverse chemical scaffolds. Proc. Natl Acad. Sci. USA 109, 8511-8516 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 8511-8516
-
-
Derbyshire, E.R.1
Prudencio, M.2
Mota, M.M.3
Clardy, J.4
-
45
-
-
84859080629
-
Drug screen targeted at Plasmodium liver stages identifies a potent multistage antimalarial drug
-
da Cruz, F. P. et al. Drug screen targeted at Plasmodium liver stages identifies a potent multistage antimalarial drug. J. Infect. Dis. 205, 1278-1286 (2012).
-
(2012)
J. Infect. Dis.
, vol.205
, pp. 1278-1286
-
-
Da Cruz, F.P.1
-
47
-
-
0017608061
-
Radical cure of infections with Plasmodium cynomolgi: A function of total 8-aminoquinoline dose
-
Schmidt, L. H., Fradkin, R., Vaughan, D. & Rasco, J. Radical cure of infections with Plasmodium cynomolgi: a function of total 8-aminoquinoline dose. Am. J. Trop. Med. Hyg. 26, 1116-1128 (1977). (Pubitemid 8260922)
-
(1977)
American Journal of Tropical Medicine and Hygiene
, vol.26
, Issue.6
, pp. 1116-1128
-
-
Schmidt, L.H.1
Fradkin, R.2
Vaughan, D.3
Rasco, J.4
-
48
-
-
60549099364
-
Primaquine revisited six decades after its discovery
-
Vale, N., Moreira, R. & Gomes, P. Primaquine revisited six decades after its discovery. Eur. J. Med. Chem. 44, 937-953 (2009).
-
(2009)
Eur. J. Med. Chem.
, vol.44
, pp. 937-953
-
-
Vale, N.1
Moreira, R.2
Gomes, P.3
-
49
-
-
84862618379
-
Relapse of imported vivax malaria despite standard-dose primaquine therapy: An investigation with molecular genotyping analyses
-
Chiang, T. Y., Lin, W. C., Kuo, M. C., Ji, D. D. & Fang, C. T. Relapse of imported vivax malaria despite standard-dose primaquine therapy: an investigation with molecular genotyping analyses. Clin. Microbiol. Infect. 18, E232-E234 (2012).
-
(2012)
Clin. Microbiol. Infect.
, vol.18
-
-
Chiang, T.Y.1
Lin, W.C.2
Kuo, M.C.3
Ji, D.D.4
Fang, C.T.5
-
50
-
-
84876779640
-
Genetic analysis of primaquine tolerance in a patient with relapsing vivax malaria
-
Bright, A. T. et al. Genetic analysis of primaquine tolerance in a patient with relapsing vivax malaria. Emerg. Infect. Dis. 19, 802 (2013).
-
(2013)
Emerg. Infect. Dis.
, vol.19
, pp. 802
-
-
Bright, A.T.1
-
51
-
-
84882580906
-
A Plasmodium falciparum screening assay for anti-gametocyte drugs based on parasite lactate dehydrogenase detection
-
D'Alessandro, S. et al. A Plasmodium falciparum screening assay for anti-gametocyte drugs based on parasite lactate dehydrogenase detection. J. Antimicrob. Chemother. 68, 2048-2058 (2013).
-
(2013)
J. Antimicrob. Chemother.
, vol.68
, pp. 2048-2058
-
-
D'Alessandro, S.1
-
52
-
-
84868102213
-
A high-throughput assay for the identification of malarial transmission-blocking drugs and vaccines
-
Delves, M. J. et al. A high-throughput assay for the identification of malarial transmission-blocking drugs and vaccines. Int. J. Parasitol. 42, 999-1006 (2012).
-
(2012)
Int. J. Parasitol.
, vol.42
, pp. 999-1006
-
-
Delves, M.J.1
-
53
-
-
84934440194
-
Assessing transmission blockade in Plasmodium spp
-
Blagborough, A. M. et al. Assessing transmission blockade in Plasmodium spp. Methods Mol. Biol. 923, 577-600 (2013).
-
(2013)
Methods Mol. Biol.
, vol.923
, pp. 577-600
-
-
Blagborough, A.M.1
-
54
-
-
4344630762
-
Identification of an antimalarial synthetic trioxolane drug development candidate
-
DOI 10.1038/nature02779
-
Vennerstrom, J. L. et al. Identification of an antimalarial synthetic trioxolane drug development candidate. Nature 430, 900-904 (2004) (Pubitemid 39119218)
-
(2004)
Nature
, vol.430
, Issue.7002
, pp. 900-904
-
-
Vennerstrom, J.L.1
Arbe-Barnes, S.2
Brun, R.3
Charman, S.A.4
Chiu, F.C.K.5
Chollet, J.6
Dong, Y.7
Dorn, A.8
Hunziker, D.9
Matile, H.10
McIntosh, K.11
Padmanilayam, M.12
Santo Tomas, J.13
Scheurer, C.14
Scorneaux, B.15
Tang, Y.16
Urwyler, H.17
Wittlin, S.18
Charman, W.H.19
-
55
-
-
79960992639
-
Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion
-
Klonis, N. et al. Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion. Proc. Natl Acad. Sci. USA 108, 11405-11410 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 11405-11410
-
-
Klonis, N.1
-
56
-
-
67349124872
-
The global portfolio of new antimalarial medicines under development
-
Olliaro, P. & Wells, T. N. The global portfolio of new antimalarial medicines under development. Clin. Pharmacol. Ther. 85, 584-595 (2009).
-
(2009)
Clin. Pharmacol. Ther.
, vol.85
, pp. 584-595
-
-
Olliaro, P.1
Wells, T.N.2
-
57
-
-
77952765495
-
If artemisinin drugs fail what's plan B?
-
Enserink, M. If artemisinin drugs fail, what's plan B? Science 328, 846 (2010).
-
(2010)
Science
, vol.328
, pp. 846
-
-
Enserink, M.1
-
58
-
-
79952732772
-
Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria
-
Charman, S. A. et al. Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria. Proc. Natl Acad. Sci. USA 108, 4400-4405 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 4400-4405
-
-
Charman, S.A.1
-
59
-
-
84857769077
-
The activities of current antimalarial drugs on the life cycle stages of Plasmodium: A comparative study with human and rodent parasites
-
Delves, M. et al. The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites. PLoS Med. 9, e1001169 (2012).
-
(2012)
PLoS Med.
, vol.9
-
-
Delves, M.1
-
60
-
-
84872260566
-
First-in-man safety and pharmacokinetics of synthetic ozonide OZ439 demonstrates an improved exposure profile relative to other peroxide antimalarials
-
Moehrle, J. J. et al. First-in-man safety and pharmacokinetics of synthetic ozonide OZ439 demonstrates an improved exposure profile relative to other peroxide antimalarials. Br. J. Clin. Pharmacol. 75, 524-537 (2013).
-
(2013)
Br. J. Clin. Pharmacol.
, vol.75
, pp. 524-537
-
-
Moehrle, J.J.1
-
61
-
-
77955336999
-
Identification of a 1 2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins
-
O'Neill, P. M. et al. Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins. Angew. Chem. Int. Ed. Engl. 49, 5693-5697 (2010).
-
(2010)
Angew. Chem. Int. Ed. Engl.
, vol.49
, pp. 5693-5697
-
-
O'Neill, P.M.1
-
62
-
-
84875737819
-
Comparative antimalarial activities and ADME profiles of ozonides ( 1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres
-
Wang, X. et al. Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres. J. Med. Chem. 56, 2547-2555 (2013).
-
(2013)
J. Med. Chem.
, vol.56
, pp. 2547-2555
-
-
Wang, X.1
-
63
-
-
0027771586
-
The chemotherapy of rodent malaria. LI. Studies on a new 8-aminoquinoline, WR 238,605
-
Peters, W., Robinson, B. L. & Milhous, W. K. The chemotherapy of rodent malaria. LI. Studies on a new 8-aminoquinoline, WR 238,605. Ann. Trop. Med. Parasitol. 87, 547-552 (1993). (Pubitemid 24029001)
-
(1993)
Annals of Tropical Medicine and Parasitology
, vol.87
, Issue.6
, pp. 547-552
-
-
Peters, W.1
Robinson, B.L.2
Milhous, W.K.3
-
64
-
-
44449113132
-
Antiparasitic activities and toxicities of individual enantiomers of the 8-aminoquinoline 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3,4- dichlorophenoxy]quinoline succinate
-
DOI 10.1128/AAC.00645-07
-
Nanayakkara, N. P. et al. Antiparasitic activities and toxicities of individual enantiomers of the 8-aminoquinoline 8-[(4-amino-1-methylbutyl)amino]- 6-methoxy-4-methyl-5-[3,4-dichlorophenoxy]quinol ine succinate. Antimicrob. Agents Chemother. 52, 2130-2137 (2008). (Pubitemid 351758550)
-
(2008)
Antimicrobial Agents and Chemotherapy
, vol.52
, Issue.6
, pp. 2130-2137
-
-
Nanayakkara, N.P.D.1
Ager Jr., A.L.2
Bartlett, M.S.3
Yardley, V.4
Croft, S.L.5
Khan, I.A.6
McChesney, J.D.7
Walker, L.A.8
-
65
-
-
67651004913
-
Resistance to therapies for infection by Plasmodium vivax
-
Baird, J. K. Resistance to therapies for infection by Plasmodium vivax. Clin. Microbiol. Rev. 22, 508-534 (2009).
-
(2009)
Clin. Microbiol. Rev.
, vol.22
, pp. 508-534
-
-
Baird, J.K.1
-
66
-
-
84864473749
-
CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline, anti-malarial drug primaquine
-
Pybus, B. S. et al. CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline, anti-malarial drug primaquine. Malar. J. 11, 259 (2012).
-
(2012)
Malar. J.
, vol.11
, pp. 259
-
-
Pybus, B.S.1
-
67
-
-
78751575820
-
Optimization of endochin-like quinolones for antimalarial activity
-
Winter, R. et al. Optimization of endochin-like quinolones for antimalarial activity. Exp. Parasitol. 127, 545-551 (2011).
-
(2011)
Exp. Parasitol.
, vol.127
, pp. 545-551
-
-
Winter, R.1
-
68
-
-
84876002292
-
Quinolone-3-diarylethers: A new class of antimalarial drug
-
Nilsen, A. et al. Quinolone-3-diarylethers: a new class of antimalarial drug. Sci. Transl. Med. 5, 177ra37 (2013).
-
(2013)
Sci. Transl. Med.
, vol.5
, pp. 177-237
-
-
Nilsen, A.1
-
69
-
-
76749095030
-
Next-generation antimalarial drugs: Hybrid molecules as a new strategy in drug design
-
Muregi, F. W. & Ishih, A. Next-generation antimalarial drugs: hybrid molecules as a new strategy in drug design. Drug Dev. Res. 71, 20-32 (2010).
-
(2010)
Drug Dev. Res.
, vol.71
, pp. 20-32
-
-
Muregi, F.W.1
Ishih, A.2
-
70
-
-
67349189204
-
Discovery of dual function acridones as a new antimalarial chemotype
-
Kelly, J. X. et al. Discovery of dual function acridones as a new antimalarial chemotype. Nature 459, 270-273 (2009).
-
(2009)
Nature
, vol.459
, pp. 270-273
-
-
Kelly, J.X.1
-
71
-
-
79955626199
-
The antimalarial ferroquine: Role of the metal and intramolecular hydrogen bond in activity and resistance
-
Dubar, F. et al. The antimalarial ferroquine: role of the metal and intramolecular hydrogen bond in activity and resistance. ACS Chem. Biol. 6, 275-287 (2011).
-
(2011)
ACS Chem. Biol.
, vol.6
, pp. 275-287
-
-
Dubar, F.1
-
72
-
-
58149387664
-
Ferroquinean ingenious antimalarial drug: Thoughts on the mechanism of action
-
Dubar, F., Khalife, J., Brocard, J., Dive, D. & Biot, C. Ferroquine, an ingenious antimalarial drug: thoughts on the mechanism of action. Molecules 13, 2900-2907 (2008).
-
(2008)
Molecules
, vol.13
, pp. 2900-2907
-
-
Dubar, F.1
Khalife, J.2
Brocard, J.3
Dive, D.4
Biot, C.5
-
73
-
-
34447568519
-
Cardiotoxicity of antimalarial drugs
-
DOI 10.1016/S1473-3099(07)70187-1, PII S1473309907701871
-
White, N. J. Cardiotoxicity of antimalarial drugs. Lancet Infect. Dis. 7, 549-558 (2007). (Pubitemid 47077715)
-
(2007)
Lancet Infectious Diseases
, vol.7
, Issue.8
, pp. 549-558
-
-
White, N.J.1
-
74
-
-
0038471102
-
The impact of drug-induced QT interval prolongation on drug discovery and development
-
DOI 10.1038/nrd1108
-
Fermini, B. & Fossa, A. A. The impact of drug-induced QT interval prolongation on drug discovery and development. Nature Rev. Drug Discov. 2, 439-447 (2003). (Pubitemid 37361725)
-
(2003)
Nature Reviews Drug Discovery
, vol.2
, Issue.6
, pp. 439-447
-
-
Fermini, B.1
Fossa, A.A.2
-
75
-
-
33845903833
-
Drugs for bad bugs: Confronting the challenges of antibacterial discovery
-
DOI 10.1038/nrd2201, PII NRD2201
-
Payne, D. J., Gwynn, M. N., Holmes, D. J. & Pompliano, D. L. Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nature Rev. Drug Discov. 6, 29-40 (2007) (Pubitemid 46020284)
-
(2007)
Nature Reviews Drug Discovery
, vol.6
, Issue.1
, pp. 29-40
-
-
Payne, D.J.1
Gwynn, M.N.2
Holmes, D.J.3
Pompliano, D.L.4
-
76
-
-
84867653932
-
Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target
-
Yuthavong, Y. et al. Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target. Proc. Natl Acad. Sci. USA 109, 16823-16828 (2012)
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 16823-16828
-
-
Yuthavong, Y.1
-
77
-
-
84865832714
-
The global pipeline of new medicines for the control and elimination of malaria
-
Anthony, M. P., Burrows, J. N., Duparc, S., Moehrle, J. J. & Wells, T. N. The global pipeline of new medicines for the control and elimination of malaria. Malar. J. 11, 316 (2012).
-
(2012)
Malar. J.
, vol.11
, pp. 316
-
-
Anthony, M.P.1
Burrows, J.N.2
Duparc, S.3
Moehrle, J.J.4
Wells, T.N.5
-
78
-
-
0028109373
-
The effects of antimalarials on the plasmodium falciparum dihydroorotate dehydrogenase
-
DOI 10.1006/expr.1994.1058
-
Ittarat, I., Asawamahasakda, W. & Meshnick, S. R. The effects of antimalarials on the Plasmodium falciparum dihydroorotate dehydrogenase. Exp. Parasitol. 79, 50-56 (1994). (Pubitemid 24270438)
-
(1994)
Experimental Parasitology
, vol.79
, Issue.1
, pp. 50-56
-
-
Ittarat, I.1
Asawamahasakda, W.2
Meshnick, S.R.3
-
79
-
-
0020136030
-
Enzymes of purine and pyrimidine metabolism from the human malaria parasite Plasmodium falciparum
-
Reyes, P. et al. Enzymes of purine and pyrimidine metabolism from the human malaria parasite, Plasmodium falciparum. Mol. Biochem. Parasitol. 5, 275-290 (1982).
-
(1982)
Mol. Biochem. Parasitol
, vol.5
, pp. 275-290
-
-
Reyes, P.1
-
80
-
-
20444470318
-
High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase
-
DOI 10.1074/jbc.M501100200
-
Baldwin, J. et al. High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J. Biol. Chem. 280, 21847-21853 (2005). (Pubitemid 40827835)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.23
, pp. 21847-21853
-
-
Baldwin, J.1
Michnoff, C.H.2
Malmquist, N.A.3
White, J.4
Roth, M.G.5
Rathod, P.K.6
Phillips, M.A.7
-
81
-
-
64549087994
-
Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice
-
Gujjar, R. et al. Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice. J. Med. Chem. 52, 1864-1872 (2009).
-
(2009)
J. Med. Chem.
, vol.52
, pp. 1864-1872
-
-
Gujjar, R.1
-
82
-
-
79958100876
-
Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice
-
Gujjar, R. et al. Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice. J. Med. Chem. 54, 3935-3949 (2011).
-
(2011)
J. Med. Chem.
, vol.54
, pp. 3935-3949
-
-
Gujjar, R.1
-
83
-
-
79961223551
-
Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential
-
Coteron, J. M. et al. Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential. J. Med. Chem. 54, 5540-5561 (2011).
-
(2011)
J. Med. Chem.
, vol.54
, pp. 5540-5561
-
-
Coteron, J.M.1
-
84
-
-
58049219752
-
Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase
-
Patel, V. et al. Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J. Biol. Chem. 283, 35078-35085 (2008).
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 35078-35085
-
-
Patel, V.1
-
85
-
-
77958511348
-
Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model
-
Booker, M. L. et al. Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model. J. Biol. Chem. 285, 33054-33064 (2010).
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 33054-33064
-
-
Booker, M.L.1
-
86
-
-
77952780117
-
Structure-based design of novel small-molecule inhibitors of Plasmodium falciparum
-
Kortagere, S. et al. Structure-based design of novel small-molecule inhibitors of Plasmodium falciparum. J. Chem. Inf. Model. 50, 840-849 (2010).
-
(2010)
J. Chem. Inf. Model.
, vol.50
, pp. 840-849
-
-
Kortagere, S.1
-
87
-
-
62549103382
-
Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum
-
Dharia, N. V. et al. Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum. Genome Biol. 10, R21 (2009).
-
(2009)
Genome Biol.
, vol.10
-
-
Dharia, N.V.1
-
88
-
-
84862286628
-
Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin
-
Hoepfner, D. et al. Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin. Cell Host Microbe 11, 654-663 (2012).
-
(2012)
Cell Host Microbe
, vol.11
, pp. 654-663
-
-
Hoepfner, D.1
-
89
-
-
79952162829
-
Validation of isoleucine utilization targets in Plasmodium falciparum
-
Istvan, E. S. et al. Validation of isoleucine utilization targets in Plasmodium falciparum. Proc. Natl Acad. Sci. USA 108, 1627-1632 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 1627-1632
-
-
Istvan, E.S.1
-
90
-
-
84555196897
-
Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors
-
Dong, C. K. et al. Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors. Chem. Biol. 18, 1602-1610 (2011).
-
(2011)
Chem. Biol.
, vol.18
, pp. 1602-1610
-
-
Dong, C.K.1
-
91
-
-
81555228431
-
A chemical genomic analysis of decoquinate, a Plasmodium falciparum cytochrome b inhibitor
-
Nam, T. G. et al. A chemical genomic analysis of decoquinate, a Plasmodium falciparum cytochrome b inhibitor. ACS Chem. Biol. 6, 1214-1222 (2011).
-
(2011)
ACS Chem. Biol.
, vol.6
, pp. 1214-1222
-
-
Nam, T.G.1
-
92
-
-
84874710057
-
ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase
-
Zhou, H., Sun, L., Yang, X.-L. & Schimmel, P. ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase. Nature 494, 121-124 (2012).
-
(2012)
Nature
, vol.494
, pp. 121-124
-
-
Zhou, H.1
Sun, L.2
Yang, X.-L.3
Schimmel, P.4
-
93
-
-
84860330836
-
Characterization of Plasmodium liver stage inhibition by halofuginone
-
Derbyshire, E. R., Mazitschek, R. & Clardy, J. Characterization of Plasmodium liver stage inhibition by halofuginone. ChemMedChem. 7, 844-849 (2012).
-
(2012)
ChemMedChem
, vol.7
, pp. 844-849
-
-
Derbyshire, E.R.1
Mazitschek, R.2
Clardy, J.3
-
94
-
-
78049447418
-
Identification of inhibitors for putative malaria drug targets among novel antimalarial compounds
-
Crowther, G. J. et al. Identification of inhibitors for putative malaria drug targets among novel antimalarial compounds. Mol. Biochem. Parasitol. 175, 21-29 (2011).
-
(2011)
Mol. Biochem. Parasitol.
, vol.175
, pp. 21-29
-
-
Crowther, G.J.1
-
95
-
-
79952741062
-
Natural products as starting points for future anti-malarial therapies: Going back to our roots
-
Wells, T. N. Natural products as starting points for future anti-malarial therapies: going back to our roots. Malar. J. 10, S3 (2011).
-
(2011)
Malar. J.
, vol.10
-
-
Wells, T.N.1
-
96
-
-
77955340711
-
Antimalarial activity and toxicity evaluation of a quantified Nauclea pobeguinii extract
-
Mesia, K. et al. Antimalarial activity and toxicity evaluation of a quantified Nauclea pobeguinii extract. J. Ethnopharmacol. 131, 10-16 (2010).
-
(2010)
J. Ethnopharmacol.
, vol.131
, pp. 10-16
-
-
Mesia, K.1
-
97
-
-
84857233191
-
Antimalarial efficacy of a quantified extract of Nauclea pobeguinii stem bark in human adult volunteers with diagnosed uncomplicated falciparum malaria. Part 1: A clinical phase IIA trial
-
Mesia, K. et al. Antimalarial efficacy of a quantified extract of Nauclea pobeguinii stem bark in human adult volunteers with diagnosed uncomplicated falciparum malaria. part 1: A clinical phase IIA trial. Planta Med. 78, 211-218 (2011).
-
(2011)
Planta Med.
, vol.78
, pp. 211-218
-
-
Mesia, K.1
-
98
-
-
84862831908
-
Chromatographic profiling and identification of two new iridoid-indole alkaloids by UPLC-MS and HPLC-SPE-NMR analysis of an antimalarial extract from Nauclea pobeguinii
-
Xu, Y.-J. et al. Chromatographic profiling and identification of two new iridoid-indole alkaloids by UPLC-MS and HPLC-SPE-NMR analysis of an antimalarial extract from Nauclea pobeguinii. Phytochem. Lett. 5, 316-319 (2012).
-
(2012)
Phytochem. Lett.
, vol.5
, pp. 316-319
-
-
Xu, Y.-J.1
-
99
-
-
70649095189
-
Argemone mexicana decoction versus artesunate-amodiaquine for the management of malaria in Mali: Policy and public-health implications
-
Graz, B. et al. Argemone mexicana decoction versus artesunate-amodiaquine for the management of malaria in Mali: policy and public-health implications. Trans. R. Soc. Trop. Med. Hyg. 104, 33-41 (2010).
-
(2010)
Trans. R. Soc. Trop. Med. Hyg.
, vol.104
, pp. 33-41
-
-
Graz, B.1
-
100
-
-
70350031257
-
Dispersible formulation of artemether/lumefantrine: Specifically developed for infants and young children
-
Abdulla, S. & Sagara, I. Dispersible formulation of artemether/lumefantrine: specifically developed for infants and young children. Malar. J. S1-S7 (2009).
-
(2009)
Malar. J
, vol.8
-
-
Abdulla, S.1
Sagara, I.2
-
101
-
-
77952303346
-
Efficacy and safety of a fixed-dose oral combination of pyronaridine-artesunate compared with artemether-lumefantrine in children and adults with uncomplicated Plasmodium falciparum malaria: A randomised non-inferiority trial
-
Tshefu, A. K. et al. Efficacy and safety of a fixed-dose oral combination of pyronaridine-artesunate compared with artemether-lumefantrine in children and adults with uncomplicated Plasmodium falciparum malaria: a randomised non-inferiority trial. Lancet 375, 1457-1467 (2010).
-
(2010)
Lancet
, vol.375
, pp. 1457-1467
-
-
Tshefu, A.K.1
-
102
-
-
84875965967
-
Creative solutions to extraordinary challenges in clinical trials: Methodology of a Phase III trial of azithromycin and chloroquine fixed-dose combination in pregnant women in Africa
-
Chandra, R. S. et al. Creative solutions to extraordinary challenges in clinical trials: methodology of a Phase III trial of azithromycin and chloroquine fixed-dose combination in pregnant women in Africa. Malar. J. 12, 1-8 (2013).
-
(2013)
Malar. J.
, vol.12
, pp. 1-8
-
-
Chandra, R.S.1
-
103
-
-
84860722723
-
Dihydroartemisinin/Piperaquine: A review of its use in the treatment of uncomplicated Plasmodium falciparum malaria
-
Keating, G. M. Dihydroartemisinin/Piperaquine: a review of its use in the treatment of uncomplicated Plasmodium falciparum malaria. Drugs 72, 937-961 (2012).
-
(2012)
Drugs
, vol.72
, pp. 937-961
-
-
Keating, G.M.1
-
104
-
-
0036655646
-
The safety and efficacy of sulfadoxine-pyrimethamine, amodiaquine, and their combination in the treatment of uncomplicated Plasmodium falciparum malaria
-
Schellenberg, D. et al. The safety and efficacy of sulfadoxine- pyrimethamine, amodiaquine, and their combination in the treatment of uncomplicated Plasmodium falciparum malaria. Am. J. Trop. Med. Hyg. 67, 17-23 (2002). (Pubitemid 35034314)
-
(2002)
American Journal of Tropical Medicine and Hygiene
, vol.67
, Issue.1
, pp. 17-23
-
-
Schellenberg, D.1
Kahigwa, E.2
Drakeley, C.3
Malende, A.4
Wigayi, J.5
Msokame, C.6
Aponte, J.J.7
Tanner, M.8
Mshinda, H.9
Menendez, C.10
Alonso, P.L.11
-
105
-
-
84874065243
-
Beyond insecticides: New thinking on an ancient problem
-
McGraw, E. A. & O'Neill, S. L. Beyond insecticides: new thinking on an ancient problem. Nature Rev. Microbiol. 11, 181-193 (2013).
-
(2013)
Nature Rev. Microbiol
, vol.11
, pp. 181-193
-
-
McGraw, E.A.1
O'Neill, S.L.2
-
106
-
-
84877607408
-
Wolbachia invades Anopheles stephensi populations and induces refractoriness to Plasmodium infection
-
Bian, G. et al. Wolbachia invades Anopheles stephensi populations and induces refractoriness to Plasmodium infection. Science 340, 748-751 (2013)
-
(2013)
Science
, vol.340
, pp. 748-751
-
-
Bian, G.1
-
107
-
-
81455154875
-
First results of phase 3 trial of RTS S/AS01 malaria vaccine in African children
-
Agnandji, S. T. et al. First results of phase 3 trial of RTS, S/AS01 malaria vaccine in African children. N. Engl. J. Med. 365, 1863 (2011).
-
(2011)
N. Engl. J. Med.
, vol.365
-
-
Agnandji, S.T.1
-
108
-
-
84871037616
-
A phase 3 trial of RTS S/AS01 malaria vaccine in African infants
-
D'Alessandro, U. A phase 3 trial of RTS, S/AS01 malaria vaccine in African infants. New Engl. J. Med. 367, 2284-2295 (2012).
-
(2012)
New Engl. J. Med.
, vol.367
, pp. 2284-2295
-
-
D'Alessandro, U.1
-
109
-
-
84873564071
-
Immune mechanisms in malaria: New insights in vaccine development
-
Riley, E. M. & Stewart, V. A. Immune mechanisms in malaria: new insights in vaccine development. Nature Med. 19, 168-178 (2013).
-
(2013)
Nature Med.
, vol.19
, pp. 168-178
-
-
Riley, E.M.1
Stewart, V.A.2
-
110
-
-
85081454536
-
-
World Health Organization. Guidelines for the treatment of malaria. Second edition [online] WHO
-
World Health Organization. Guidelines for the treatment of malaria. Second edition [online], http://www.who.int/malaria/publications/atoz/ 9789241547925/en/index.html (WHO, 2010).
-
(2010)
-
-
-
111
-
-
33750140518
-
The silent path to thousands of merozoites: The Plasmodium liver stage
-
DOI 10.1038/nrmicro1529, PII NRMICRO1529
-
Prudencio, M., Rodriguez, A. & Mota, M. M. The silent path to thousands of merozoites: the Plasmodium liver stage. Nature Rev. Microbiol. 4, 849-856 (2006). (Pubitemid 44593951)
-
(2006)
Nature Reviews Microbiology
, vol.4
, Issue.11
, pp. 849-856
-
-
Prudencio, M.1
Rodriguez, A.2
Mota, M.M.3
-
112
-
-
41349123227
-
Sex in Plasmodium: A sign of commitment
-
Dixon, M. W., Thompson, J., Gardiner, D. L. & Trenholme, K. R. Sex in Plasmodium: a sign of commitment. Trends Parasitol. 24, 168-175 (2008).
-
(2008)
Trends Parasitol.
, vol.24
, pp. 168-175
-
-
Dixon, M.W.1
Thompson, J.2
Gardiner, D.L.3
Trenholme, K.R.4
-
113
-
-
84877855333
-
Malaria-infected erythrocyte-derived microvesicles mediate cellular communication within the parasite population and with the host immune system
-
Mantel, P. Y. et al. Malaria-infected erythrocyte-derived microvesicles mediate cellular communication within the parasite population and with the host immune system. Cell Host Microbe 13, 521-534 (2013).
-
(2013)
Cell Host Microbe
, vol.13
, pp. 521-534
-
-
Mantel, P.Y.1
-
114
-
-
84878291129
-
Cell-cell communication between malaria-infected red blood cells via exosome-like vesicles
-
Regev-Rudzki, N. et al. Cell-cell communication between malaria-infected red blood cells via exosome-like vesicles. Cell 153, 1120-1133 (2013).
-
(2013)
Cell
, vol.153
, pp. 1120-1133
-
-
Regev-Rudzki, N.1
-
115
-
-
70349545938
-
Malaria parasite development in the mosquito and infection of the mammalian host
-
Aly, A. S., Vaughan, A. M. & Kappe, S. H. Malaria parasite development in the mosquito and infection of the mammalian host. Annu. Rev. Microbiol. 63, 195-221 (2009).
-
(2009)
Annu. Rev. Microbiol.
, vol.63
, pp. 195-221
-
-
Aly, A.S.1
Vaughan, A.M.2
Kappe, S.H.3
-
116
-
-
68049123592
-
Artemisinin resistance in Plasmodium falciparum malaria
-
Dondorp, A. M. et al. Artemisinin resistance in Plasmodium falciparum malaria. N. Engl. J. Med. 361, 455-467 (2009).
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 455-467
-
-
Dondorp, A.M.1
-
117
-
-
84861461519
-
Emergence of artemisinin-resistant malaria on the western border of Thailand: A longitudinal study
-
Phyo, A. P. et al. Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study. Lancet 379, 1960-1966 (2012).
-
(2012)
Lancet
, vol.379
, pp. 1960-1966
-
-
Phyo, A.P.1
-
118
-
-
84859506329
-
A major genome region underlying artemisinin resistance in malaria
-
Cheeseman, I. H. et al. A major genome region underlying artemisinin resistance in malaria. Science 336, 79-82 (2012).
-
(2012)
Science
, vol.336
, pp. 79-82
-
-
Cheeseman, I.H.1
-
119
-
-
84878715473
-
Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia
-
Miotto, O. et al. Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia. Nature Genet. 45, 648-655 (2013).
-
(2013)
Nature Genet.
, vol.45
, pp. 648-655
-
-
Miotto, O.1
-
120
-
-
84871944250
-
Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia
-
Takala-Harrison, S. et al. Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia. Proc. Natl Acad. Sci. USA 110, 240-245 (2013).
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 240-245
-
-
Takala-Harrison, S.1
-
121
-
-
79961008996
-
Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription
-
Mok, S. et al. Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription. BMC Genomics 12, 391 (2011).
-
(2011)
BMC Genomics
, vol.12
, pp. 391
-
-
Mok, S.1
-
122
-
-
72849131679
-
Noninvasive real-time monitoring of liver-stage development of bioluminescent Plasmodium parasites
-
Mwakingwe, A. et al. Noninvasive real-time monitoring of liver-stage development of bioluminescent Plasmodium parasites. J. Infect. Dis. 200, 1470-1478 (2009).
-
(2009)
J. Infect. Dis.
, vol.200
, pp. 1470-1478
-
-
Mwakingwe, A.1
-
123
-
-
0021049353
-
Relationships between chemical structures of 8-aminoquinolines and their capacities for radical cure of infections with Plasmodium cynomolgi in rhesus monkeys
-
Schmidt, L. H. Relationships between chemical structures of 8-aminoquinolines and their capacities for radical cure of infections with Plasmodium cynomolgi in rhesus monkeys. Antimicrob. Agents Chemother. 24, 615-652 (1983). (Pubitemid 14203859)
-
(1983)
Antimicrobial Agents and Chemotherapy
, vol.24
, Issue.5
, pp. 615-652
-
-
Schmidt, L.H.1
-
124
-
-
12244307892
-
Simple in vitro assay for determining the sensitivity of Plasmodium vivax isolates from fresh human blood to antimalarials in areas where P. Vivax Is endemic
-
DOI 10.1128/AAC.47.1.170-173.2003
-
Russell, B. M. et al. Simple in vitro assay for determining the sensitivity of Plasmodium vivax isolates from fresh human blood to antimalarials in areas where P. vivax is endemic. Antimicrob. Agents Chemother. 47, 170-173 (2003). (Pubitemid 36070360)
-
(2003)
Antimicrobial Agents and Chemotherapy
, vol.47
, Issue.1
, pp. 170-173
-
-
Russell, B.M.1
Udomsangpetch, R.2
Rieckmann, K.H.3
Kotecka, B.M.4
Coleman, R.E.5
Sattabongkot, J.6
-
125
-
-
70349313478
-
Improved murine model of malaria using Plasmodium falciparum competent strains and non-myelodepleted NOD-scid IL2Rnull mice engrafted with human erythrocytesx
-
Jimenez-Diaz, M. B. et al. Improved murine model of malaria using Plasmodium falciparum competent strains and non-myelodepleted NOD-scid IL2R?null mice engrafted with human erythrocytes. Antimicrob. Agents Chemother. 53, 4533-4536 (2009).
-
(2009)
Antimicrob. Agents Chemother
, vol.53
, pp. 4533-4536
-
-
Jimenez-Diaz, M.B.1
-
126
-
-
84859728437
-
Activity of clinically relevant antimalarial drugs on Plasmodium falciparum mature gametocytes in an ATP bioluminescence transmission blocking" assay
-
Lelievre, J. et al. Activity of clinically relevant antimalarial drugs on Plasmodium falciparum mature gametocytes in an ATP bioluminescence "transmission blocking" assay. PLoS ONE 7, e35019 (2012).
-
(2012)
PLoS ONE
, vol.7
-
-
Lelievre, J.1
-
127
-
-
82755197376
-
Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue
-
Adjalley, S. H. et al. Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue. Proc. Natl Acad. Sci. USA 108, E1214-E1223 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
-
-
Adjalley, S.H.1
-
128
-
-
84874626403
-
Qualification of standard membrane-feeding assay with Plasmodium falciparum malaria and potential improvements for future assays
-
Miura, K. et al. Qualification of standard membrane-feeding assay with Plasmodium falciparum malaria and potential improvements for future assays. PLoS ONE 8, e57909 (2013).
-
(2013)
PLoS ONE
, vol.8
-
-
Miura, K.1
-
129
-
-
84868087312
-
Measuring the blockade of malaria transmission-an analysis of the Standard Membrane Feeding Assay
-
Churcher, T. S. et al. Measuring the blockade of malaria transmission-an analysis of the Standard Membrane Feeding Assay. Int. J. Parasitol. 42, 1037-1044 (2012).
-
(2012)
Int. J. Parasitol.
, vol.42
, pp. 1037-1044
-
-
Churcher, T.S.1
-
130
-
-
80855133585
-
Plasmodium falciparum parasites are killed by a transition state analogue of purine nucleoside phosphorylase in a primate animal model
-
Cassera, M. B. et al. Plasmodium falciparum parasites are killed by a transition state analogue of purine nucleoside phosphorylase in a primate animal model. PLoS ONE 6, e26916 (2011).
-
(2011)
PLoS ONE
, vol.6
-
-
Cassera, M.B.1
-
131
-
-
34248209201
-
Tafenoquine: A promising new antimalarial agent
-
DOI 10.1517/13543784.16.5.705
-
Crockett, M. & Kain, K. C. Tafenoquine: a promising new antimalarial agent. Expert Opin. Investig. Drugs 16, 705-715 (2007). (Pubitemid 46723273)
-
(2007)
Expert Opinion on Investigational Drugs
, vol.16
, Issue.5
, pp. 705-715
-
-
Crockett, M.1
Kain, K.C.2
-
132
-
-
84862565962
-
Antimalarial efficacy of a quantified extract of Nauclea pobeguinii stem bark in human adult volunteers with diagnosed uncomplicated falciparum malaria. Part 2: A clinical Phase IIB trial
-
Mesia, K. et al. Antimalarial efficacy of a quantified extract of Nauclea pobeguinii stem bark in human adult volunteers with diagnosed uncomplicated falciparum malaria. Part 2: a clinical Phase IIB trial. Planta Med. 78, 853-860 (2012).
-
(2012)
Planta Med.
, vol.78
, pp. 853-860
-
-
Mesia, K.1
-
133
-
-
84887302542
-
Plasmodium falciparum phosphoethanolamine methyltransferase is essential for malaria transmission
-
Bobenchick, A. M. et al. Plasmodium falciparum phosphoethanolamine methyltransferase is essential for malaria transmission. Proc. Natl Acad. Sci. USA http://dx.doi.org/10.1073/pnas.1313965110 (2013).
-
(2013)
Proc. Natl Acad. Sci. USA
-
-
Bobenchick, A.M.1
-
134
-
-
84880650998
-
Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins
-
Hanson, K. K. et al. Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins. Proc. Natl Acad. Sci. USA 110, E2838-E2847 (2013).
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
-
-
Hanson, K.K.1
|