Structural basis for the functional and inhibitory mechanisms of β-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Plasmodium falciparum

Journal of Structural Biology

Volumn 176, Issue 2, 2011, Pages 238-249

  Maity, Koustav ^a   Venkata, Bharat Somireddy ^a   Kapoor, Neha ^b   Surolia, Namita ^c   Surolia, Avadhesha ^a,b   Suguna, Kaza ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

^b NATIONAL INSTITUTE OF IMMUNOLOGY   (India)

^c JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH   (India)

Author keywords

hydroxyacyl ACP dehydratase; Active site inhibitor complex; Fatty acid biosynthesis; Plasmodium falciparum; Substrate binding tunnel; X ray crystallography

Indexed keywords

CARRIER PROTEIN; PROTEIN FABZ; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; MOLECULAR DOCKING; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANTIMALARIALS; CATALYTIC DOMAIN; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; ENOYL-COA HYDRATASE; ENZYME INHIBITORS; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PLASMODIUM FALCIPARUM; PROTEIN BINDING; PROTOZOAN PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SURFACE PROPERTIES;

PLASMODIUM FALCIPARUM;

EID: 84860390428     PISSN: 10478477     EISSN: 10958657     Source Type: Journal    
DOI: 10.1016/j.jsb.2011.07.018     Document Type: Article

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