Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 8, 2009, Pages 2537-2542

  McGowan, Sheena ^a   Porter, Corrine J ^a   Lowther, Jonathan ^b   Stack, Colin M ^b,f   Golding, Sarah J ^a   Skinner Adams, Tina S ^c   Trenholme, Katharine R ^c   Teuscher, Franka ^c   Donnelly, Sheila M ^b   Grembecka, Jolanta ^d   Mucha, Artur ^e   Kafarski, Pawel ^e   Degori, Ross ^a   Buckle, Ashley M ^a   Gardiner, Donald L ^c   Whisstock, James C ^a   Dalton, John P ^b  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF TECHNOLOGY SYDNEY   (Australia)

^c QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^d UNIVERSITY OF VIRGINIA   (United States)

^e WROCLAW UNIVERSITY OF TECHNOLOGY   (Poland)

^f UNIVERSITY OF WESTERN SYDNEY   (Australia)

Author keywords

Drug design; Malaria; Protease; Structural biology

Indexed keywords

AMINOPEPTIDASE; ANTIMALARIAL AGENT; BESTATIN; COMPOUND 2; COMPOUND 4; DIPEPTIDE DERIVATIVE; HEMOGLOBIN; PLASMODIUM FALCIPARUM A M1 NEUTRAL AMINOPEPTIDASE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ANTIMALARIAL DRUG SUSCEPTIBILITY; ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME STRUCTURE; ERYTHROCYTE; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PARASITE DEVELOPMENT; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN TARGETING; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTIGENS, CD13; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME INHIBITORS; MODELS, MOLECULAR; PLASMODIUM FALCIPARUM; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

PLASMODIUM FALCIPARUM;

EID: 62449312343     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0807398106     Document Type: Article

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