The antimalarial natural product symplostatin 4 is a nanomolar inhibitor of the food vacuole falcipains

Chemistry and Biology

Volumn 19, Issue 12, 2012, Pages 1546-1555

  Stolze, Sara Christina ^a   Deu, Edgar ^b   Kaschani, Farnusch ^a   Li, Nan ^d   Florea, Bogdan I ^d   Richau, Kerstin H ^c   Colby, Tom ^c   Van Der Hoorn, Renier A L ^c   Overkleeft, Hermen S ^d   Bogyo, Matthew ^b   Kaiser, Markus ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MAX PLANCK INSTITUTE FOR PLANT BREEDING RESEARCH   (Germany)

^d LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; FALCIPAIN 2; HEMOGLOBIN; SYMPLOSTATIN 4; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; CELL REGENERATION; CELL VACUOLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ERYTHROCYTE; HUMAN; HUMAN CELL; NONHUMAN; PARASITEMIA; PHENOTYPE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ANTIMALARIALS; CYSTEINE ENDOPEPTIDASES; ENZYME INHIBITORS; ERYTHROCYTES; HEMOGLOBINS; HOST-PARASITE INTERACTIONS; HUMANS; MALARIA, FALCIPARUM; MODELS, MOLECULAR; PEPTIDES; PLASMODIUM FALCIPARUM;

PLASMODIUM FALCIPARUM;

EID: 84871579710     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2012.09.020     Document Type: Article

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