High-affinity inhibition of a family of Plasmodium falciparum proteases by a designed adaptive inhibitor

Biochemistry

Volumn 42, Issue 28, 2003, Pages 8459-8464

  Nezami, Azin ^a   Kimura, Tooru ^b   Hidaka, Koushi ^b   Kiso, Aiko ^b   Liu, Jun ^c   Kiso, Yoshiaki ^b   Goldberg, Daniel E ^c   Freire, Ernesto ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEGRADATION; ENZYMES; HEMOGLOBIN; MICROBIOLOGY;

POLYMORPHISMS;

BIOCHEMISTRY;

ADAPTIVE INHIBITOR; ALLOPHENYLNORSTATINE; ENZYME INHIBITOR; HEMOGLOBIN; HISTOASPARTYL PROTEASE; PLASMEPSIN I; PLASMEPSIN II; PLASMEPSIN IV; PROTEINASE; STATINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CELL VACUOLE; DRUG RESISTANCE; ENZYME INHIBITION; GENE MUTATION; MALARIA; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN INTERACTION;

AMINO ACID SEQUENCE; ANIMALS; ASPARTIC ENDOPEPTIDASES; CLONING, MOLECULAR; ENDOPEPTIDASES; ESCHERICHIA COLI; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PLASMODIUM FALCIPARUM; PROTEASE INHIBITORS; PROTEIN CONFORMATION; PROTOZOAN PROTEINS; RECOMBINANT PROTEINS;

PLASMODIUM FALCIPARUM;

EID: 0037780064     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi034131z     Document Type: Article

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