Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2′-Substituted triclosan derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 8, 2006, Pages 2163-2169

  Freundlich, Joel S ^a   Yu, Min ^b   Lucumi, Edinson ^c   Kuo, MacK ^c   Tsai, Han Chun ^c   Valderramos, Juan Carlos ^b   Karagyozov, Luchezar ^b   Jacobs Jr , William R ^b   Schiehser, Guy A ^a   Fidock, David A ^b   Jacobus, David P ^a   Sacchettini, James C ^c  

^a Jacobus Pharmaceutical Co Inc   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Antimalarial; Diaryl ether; Phenol

Indexed keywords

BENZYLAMINE DERIVATIVE; PIPERAZINE DERIVATIVE; PIPERIDINE DERIVATIVE; TRICLOSAN;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME PURIFICATION; IC 50; NONHUMAN; PARASITE CULTIVATION; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANIMALS; ANTIMALARIALS; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, MICROBIAL; ENOYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (NADH); ETHERS; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP; TRICLOSAN;

PLASMODIUM FALCIPARUM;

EID: 33644802299     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.01.051     Document Type: Article

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