Structural analysis of malaria-parasite lysyl-tRNA synthetase provides a platform for drug development

Acta Crystallographica Section D: Biological Crystallography

Volumn 69, Issue 5, 2013, Pages 785-795

  Khan, Sameena ^a   Garg, Ankur ^a   Camacho, Noelia ^b   Van Rooyen, Jason ^d   Kumar Pole, Anil ^a   Belrhali, Hassan ^d   Ribas De Pouplana, Lluis ^b,c   Sharma, Vinay ^e   Sharma, Amit ^a  

^a INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY ICGEB   (India)

^b INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

^c INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

^d EUROPEAN MOLECULAR BIOLOGY LABORATORY   (France)

^e BANASTHALI UNIVERSITY   (India)

Author keywords

aminoacyl tRNA synthetases; cladosporin; malaria

Indexed keywords

ADENOSINE TRIPHOSPHATE; ASPERENTIN; DIADENOSINE TETRAPHOSPHATE; DINUCLEOSIDE PHOSPHATE; LYSINE TRANSFER RNA LIGASE;

AMINO ACID SEQUENCE; AMINOACYL-TRNA SYNTHETASES; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; ENZYME ACTIVE SITE; ENZYMOLOGY; HUMAN; MALARIA; METABOLISM; MOLECULAR DOCKING; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PARASITOLOGY; PATHOGENICITY; PLASMODIUM FALCIPARUM; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

AMINOACYL-TRNA SYNTHETASES; CLADOSPORIN; MALARIA;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; BINDING SITES; CATALYTIC DOMAIN; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DINUCLEOSIDE PHOSPHATES; DRUG DESIGN; HUMANS; LYSINE-TRNA LIGASE; MALARIA; MODELS, MOLECULAR; MOLECULAR DOCKING SIMULATION; MOLECULAR SEQUENCE DATA; PLASMODIUM FALCIPARUM; PROTEIN CONFORMATION;

EID: 84877287995     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S0907444913001923     Document Type: Article

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