Hydrolysis of erythrocyte proteins by proteases of malaria parasites

Current Opinion in Hematology

Volumn 9, Issue 2, 2002, Pages 140-145

  Rosenthal, Philip J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPEPTIDASE; ANTIMALARIAL AGENT; ASPARTIC ACID; ASPARTIC PROTEINASE; CYSTEINE; CYSTEINE PROTEINASE; CYTOSKELETON PROTEIN; HEMOGLOBIN; METALLOPROTEINASE; PROTEINASE; PROTEINASE INHIBITOR; SERINE PROTEINASE;

ANTIMALARIAL ACTIVITY; ENZYME INHIBITION; ERYTHROCYTE; HUMAN; LIFE CYCLE; MALARIA; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN HYDROLYSIS; REVIEW;

ANIMALS; CYTOSKELETAL PROTEINS; ENDOPEPTIDASES; ERYTHROCYTES; HEMOGLOBINS; HUMANS; HYDROLYSIS; PLASMODIUM; PROTEASE INHIBITORS; PROTOZOAN PROTEINS;

EID: 0036183460     PISSN: 10656251     EISSN: None     Source Type: Journal    
DOI: 10.1097/00062752-200203000-00010     Document Type: Review

References (49)

1. The ears of the hippopotamus: Manifestations, determinants, and estimates of the malaria burden
2. The need for new approaches to antimalarial chemotherapy
3. An overview of chemotherapeutic targets for antimalarial drug discovery
4. Regulation of red cell membrane protein interactions: Implications for red cell function
5. The proteases and pathogenicity of parasitic protozoa
6. The Plasmodium falciparum digestive vacuole: Metabolic headquarters and choice drug target
7. Hemoglobin catabolism and iron utilization by malaria parasites
8. Hemoglobin metabolism in the malaria parasite Plasmodium falciparum
9. A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum
10. Isolation and characterization of a cysteine proteinase gene of Plasmodium falciparum
11. Characterization of native and recombinant falcipain-2, a principal trophozoite cysteine protease and essential hemoglobinase of Plasmodium falciparum
12. Expression and characterization of the Plasmodium falciparum hemoglobinase falcipain-3
13. Hemoglobin degradation in the human malaria pathogen Plasmodium falciparum: A catabolic pathway initiated by a specific aspartic protease
14. Plasmodium falciparum: Differential sensitivity in vitro to E-64 (cysteine protease inhibitor) and pepstatin A (aspartyl protease inhibitor)
15. Plasmodium falciparum: Effects of proteinase inhibitors on globin hydrolysis by cultured malaria parasites
16. Molecular characterization and inhibition of a Plasmodium falciparum aspartic hemoglobinase
17. Expression and characterisation of plasmepsin I from Plasmodium falciparum
18. High level expression and characterisation of plasmepsin II, an aspartic proteinase from Plasmodium falciparum
19. Sequence, expression and modeled structure of an aspartic proteinase from the human malaria parasite Plasmodium falciparum
20. Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway
21. Biosynthesis and maturation of the malaria aspartic hemoglobinases plasmepsins I and II
22. Identification and characterization of falcilysin, a metallopeptidase involved in hemoglobin catabolism within the malaria parasite Plasmodium falciparum
23. Generation of hemoglobin peptides in the acidic digestive vacuole of Plasmodium falciparum implicates peptide transport in amino acid production
24. Aminopeptidases from Plasmodium falciparum, Plasmodium chabaudi chabaudi and Plasmodium berghei
25. A Plasmodium falciparum aminopeptidase gene belonging to the M1 family of zinc-metallopeptidases is expressed in erythrocytic stages
26. The role of aminopeptidases in haemoglobin degradation in Plasmodium falciparum-infected erythrocytes
27. Plasmodium chabaudi chabaudi and P. falciparum: Inhibition of aminopeptidase and parasite growth by bestatin and nitrobestatin
28. Protease inhibitors
29. Malaria parasite exit from the host erythrocyte: A two-step process requiring extraerythrocytic proteolysis
30. A cysteine protease activity from Plasmodium falciparum cleaves human erythrocyte ankyrin
31. Recombinant falcipain-2 cleaves erythrocyte membrane ankyrin and protein 4.1
32. Plasmepsin II, an acidic hemoglobinase from the Plasmodium falciparum food vacuole, is active at neutral pH on the host erythrocyte membrane skeleton
33. A subtilisin-like protein in secretory organelles of Plasmodium falciparum merozoites
34. Plasmodium falciparum subtilisin-like protease 2, a merozoite candidate for the merozoite surface protein 1-42 maturase
35. PfSUB-2: A second subtilisin-like protein in Plasmodium falciparum merozoites
36. Antimalarial effects of peptide inhibitors of a Plasmodium falciparum cysteine proteinase
37. Antimalarial effects of vinyl sulfone cysteine proteinase inhibitors
38. In vitro antimalarial activity of chalcones and their derivatives
39. Synthesis and antimalarial effects of phenothiazine inhibitors of a Plasmodium falciparum cysteine protease
40. Cysteine proteinase inhibitors block early steps in hemoglobin degradation by cultured malaria parasites
41. Comparison of efficacies of cysteine protease inhibitors against five strains of Plasmodium falciparum
42. Inhibition of a Plasmodium vinckei cysteine proteinase cures murine malaria
43. Antimalarial effects in mice of orally administered peptidyl cysteine protease inhibitors
44. Structure and inhibition of plasmepsin II, a hemoglobin-degrading enzyme from Plasmodium falciparum
45. Evaluation of a structure-based statine cyclic diamino amide encoded combinatorial library against plasmepsin II and cathepsin D
46. New class of small nonpeptidyl compounds blocks Plasmodium falciparum development in vitro by inhibiting plasmepsins
47. Potent, low-molecular-weight nonpeptide inhibitors of malarial aspartyl protease plasmepsin II
48. Hemoglobin-degrading, aspartic proteases of blood-feeding parasites: Substrate specificity revealed by homology models
49. Antimalarial synergy of cysteine and aspartic protease inhibitors