Design and synthesis of inhibitors of plasmodium falciparum N -myristoyltransferase, a promising target for antimalarial drug discovery

Journal of Medicinal Chemistry

Volumn 55, Issue 20, 2012, Pages 8879-8890

  Yu, Zhiyong ^a   Brannigan, James A ^b   Moss, David K ^c   Brzozowski, A Marek ^b   Wilkinson, Anthony J ^b   Holder, Anthony A ^c   Tate, Edward W ^a   Leatherbarrow, Robin J ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF YORK   (United Kingdom)

^c NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; PROTEIN N MYRISTOYLTRANSFERASE; PROTEIN N MYRISTOYLTRANSFERASE INHIBITOR;

ARTICLE; CELL ACTIVITY; CONTROLLED STUDY; DRUG DESIGN; DRUG IDENTIFICATION; DRUG SYNTHESIS; ENZYME ACTIVITY; MALARIA; NONHUMAN; PARASITE; PLASMODIUM FALCIPARUM;

ACYLTRANSFERASES; ANTIMALARIALS; BENZOFURANS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; PIPERIDINES; PLASMODIUM FALCIPARUM; PROTEIN CONFORMATION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84867757397     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301160h     Document Type: Article

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