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Volumn 136, Issue 1, 2009, Pages 11-25
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Mutational, inhibitory and microcalorimetric analyses of Plasmodium falciparum TMP kinase. Implications for drug discovery
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Author keywords
Drug targets; Plasmodium falciparum; Site directed mutagenesis; Thymidylate kinase; TMP kinase
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Indexed keywords
GUANOSINE PHOSPHATE;
INOSINE PHOSPHATE;
PURINE NUCLEOSIDE;
PYRIMIDINE NUCLEOSIDE;
PYRIMIDINE NUCLEOSIDE DERIVATIVE;
THYMIDINE PHOSPHATE;
THYMIDYLATE KINASE;
UNCLASSIFIED DRUG;
URIDINE PHOSPHATE;
NUCLEOSIDE;
NUCLEOSIDE MONOPHOSPHATE KINASE;
ARTICLE;
BINDING AFFINITY;
CATALYSIS;
DRUG TARGETING;
ENTHALPY;
ENZYME ACTIVITY;
ENZYME BINDING;
ENZYME INHIBITION;
ENZYME POLYMORPHISM;
ENZYME SUBSTRATE;
MICROCALORIMETRY;
PLASMODIUM FALCIPARUM;
POINT MUTATION;
PRIORITY JOURNAL;
PROTEIN PROTEIN INTERACTION;
PROTEIN STRUCTURE;
PROTEIN STRUCTURE, FUNCTION AND VARIABILITY;
PROTEIN TARGETING;
SITE DIRECTED MUTAGENESIS;
THERMODYNAMICS;
ANIMAL;
CALORIMETRY;
CHEMICAL STRUCTURE;
CHEMISTRY;
DRUG ANTAGONISM;
DRUG DEVELOPMENT;
DRUG EFFECT;
ENZYME ACTIVATION;
ENZYMOLOGY;
GENETICS;
KINETICS;
METABOLISM;
PHYSIOLOGY;
PROTEIN BINDING;
PROTEIN TERTIARY STRUCTURE;
PLASMODIUM FALCIPARUM;
ANIMALS;
CALORIMETRY;
DRUG DISCOVERY;
ENZYME ACTIVATION;
KINETICS;
MODELS, MOLECULAR;
MUTAGENESIS, SITE-DIRECTED;
NUCLEOSIDE-PHOSPHATE KINASE;
NUCLEOSIDES;
PLASMODIUM FALCIPARUM;
PROTEIN BINDING;
PROTEIN STRUCTURE, TERTIARY;
THERMODYNAMICS;
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EID: 58749102067
PISSN: 00311820
EISSN: 14698161
Source Type: Journal
DOI: 10.1017/S0031182008005301 Document Type: Article |
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Times cited : (36)
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References (0)
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