IspC as target for antiinfective drug discovery: Synthesis, enantiomeric separation, and structural biology of fosmidomycin thia isosters

Journal of Medicinal Chemistry

Volumn 56, Issue 20, 2013, Pages 8151-8162

  Kunfermann, Andrea ^a   Lienau, Claudia ^b   Illarionov, Boris ^c   Held, Jana ^d   Gräwert, Tobias ^c   Behrendt, Christoph T ^b   Werner, Philipp ^c   Hähn, Saskia ^b   Eisenreich, Wolfgang ^a   Riederer, Ulrich ^c   Mordmüller, Benjamin ^d   Bacher, Adelbert ^c   Fischer, Markus ^c   Groll, Michael ^a   Kurz, Thomas ^b  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c UNIVERSITY OF HAMBURG   (Germany)

^d UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; BACTERIAL ENZYME; CHLOROQUINE; FOSMIDOMYCIN DERIVATIVE; PHOSPHONIC ACID DERIVATIVE; PROTEIN ISPC; PROTOZOAL PROTEIN; UNCLASSIFIED DRUG; [(3,4 DICHLOROPHENYL)[[2 (HYDROXYAMINO) 2 OXOETHYL]THIO](PHENYL)METHYL]PHOSPHONIC ACID; [(3,4 DICHLOROPHENYL)[[2 [HYDROXY(METHYL)AMINO] 2 OXOETHYL]THIO](PHENYL)METHYL]PHOSPHONIC ACID; [(3,4 DIFLUOROPHENYL)[[2 (HYDROXYAMINO) 2 OXOETHYL]THIO](PHENYL)METHYL]PHOSPHONIC ACID; [(3,4 DIFLUOROPHENYL)[[2 [HYDROXY(METHYL)AMINO] 2 OXOETHYL]THIO](PHENYL)METHYL]PHOSPHONIC ACID; [[[2 (HYDROXYAMINO) 2 OXOETHYL]THIO](PHENYL)METHYL]PHOSPHONIC ACID; [[[2 [HYDROXY(METHYL)AMINO] 2 OXOETHYL]THIO](4 TOLYL)METHYL]PHOSPHONIC ACID; [[[2 [HYDROXY(METHYL)AMINO] 2 OXOETHYL]THIO](NAPHTHALEN 1 YL)METHYL]PHOSPHONIC ACID; [[[2 [HYDROXY(METHYL)AMINO] 2 OXOETHYL]THIO](PHENYL)METHYL]PHOSPHONIC ACID;

ANTIBACTERIAL ACTIVITY; ANTIMALARIAL ACTIVITY; ANTIMALARIAL DRUG SUSCEPTIBILITY; ARTICLE; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENANTIOMER; ENANTIOSELECTIVITY; ESCHERICHIA COLI; IC 50; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PLASMODIUM FALCIPARUM; SEPARATION TECHNIQUE;

ALDOSE-KETOSE ISOMERASES; AMINO ACID SEQUENCE; ANTI-INFECTIVE AGENTS; BACTERIAL PROTEINS; CRYSTALLOGRAPHY, X-RAY; DRUG DISCOVERY; ESCHERICHIA COLI; FOSFOMYCIN; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; PLASMODIUM FALCIPARUM; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTOZOAN PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; STEREOISOMERISM;

EID: 84886539599     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm4012559     Document Type: Article

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