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Volumn 99, Issue 10, 2002, Pages 6591-6596
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Structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase: An essential enzyme for isoprenoid biosynthesis and target for antimicrobial drug development
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Author keywords
Escherichia coli; Mycobacterium tuberculosis; Plasmodium falciparum; Zinc enzyme
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Indexed keywords
2 C METHYL DEXTRO ERYTHRITOL 2,4 CYCLODIPHOSPHATE SYNTHASE;
ANTIINFECTIVE AGENT;
CYTIDINE DIPHOSPHATE;
ISOPRENOID;
MANGANESE;
NUCLEOTIDE;
SYNTHETASE;
UNCLASSIFIED DRUG;
ZINC ION;
ARTICLE;
CATALYSIS;
COMPLEX FORMATION;
CRYSTAL STRUCTURE;
ENZYME ACTIVE SITE;
ENZYME BINDING;
ENZYME STRUCTURE;
ESCHERICHIA COLI;
GEOMETRY;
MOLECULAR RECOGNITION;
MYCOBACTERIUM TUBERCULOSIS;
NONHUMAN;
PLASMODIUM FALCIPARUM;
PRIORITY JOURNAL;
PROTEIN FOLDING;
PROTEIN QUATERNARY STRUCTURE;
PROTEIN SECONDARY STRUCTURE;
STRUCTURE ANALYSIS;
AMINO ACID SEQUENCE;
ANTI-BACTERIAL AGENTS;
BACTERIAL PROTEINS;
BINDING SITES;
COMPUTER SIMULATION;
CRYSTALLOGRAPHY, X-RAY;
DRUG DESIGN;
ERYTHRITOL;
ESCHERICHIA COLI;
ESCHERICHIA COLI PROTEINS;
MANGANESE;
MODELS, MOLECULAR;
MOLECULAR SEQUENCE DATA;
PHOSPHORUS-OXYGEN LYASES;
PROTEIN STRUCTURE, TERTIARY;
SEQUENCE HOMOLOGY, AMINO ACID;
SUGAR PHOSPHATES;
TERPENES;
ZINC;
ACTINOBACTERIA (CLASS);
APICOMPLEXA;
BACTERIA (MICROORGANISMS);
ESCHERICHIA COLI;
MAMMALIA;
MYCOBACTERIUM;
MYCOBACTERIUM TUBERCULOSIS;
NEGIBACTERIA;
PLASMODIUM FALCIPARUM;
UNCULTURED ACTINOMYCETE;
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EID: 0037076321
PISSN: 00278424
EISSN: None
Source Type: Journal
DOI: 10.1073/pnas.102679799 Document Type: Article |
Times cited : (88)
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References (48)
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