Design, synthesis and evaluation of novel uracil acetamide derivatives as potential inhibitors of Plasmodium falciparum dUTP nucleotidohydrolase

European Journal of Medicinal Chemistry

Volumn 44, Issue 2, 2009, Pages 678-688

  McCarthy, Orla ^a,b   Musso Buendia, Alex ^c   Kaiser, Marcel ^d   Brun, Reto ^d   Ruiz Perez, Luis M ^c   Johansson, Nils Gunnar ^e   Pacanowska, Dolores Gonzalez ^c   Gilbert, Ian H ^a,b  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

^c INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

^d SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^e MEDIVIR AB   (Sweden)

Author keywords

Anti malarial; Anti plasmodial; dUTP nucleotidohydrolase; Uracil acetamide

Indexed keywords

1 [N (2 TRIPHENYLMETHYLAMINOETHYL)ACETAMIDE URACIL; 1 [N (3 TRIPHENYLMETHYLAMINOBUTYL)ACETAMIDE]URACIL; 1 [N (3 TRIPHENYLMETHYLAMINOPROPYL)ACETAMIDE]URACIL; 1 [N (TRIPHENYLMETHYL)DIAMINODI(N PROPYL)ACETAMIDE]URACIL; 1 [N (TRIPHENYLMETHYLAMINOETHYL) N (AMINOETHYL)ACETAMIDE]URACIL; 1 [N HYDROXYETHYL N (TRIPHENYLMETHYLAMINO)ETHYLACETAMIDE]URACIL; ACETAMIDE DERIVATIVE; ANTIMALARIAL AGENT; DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE; N [3 (TERT BUTYL DIPHENYL SILANYLOXY)PROPYL 2 URACIL ACETAMIDE; N [4 (TERT BUTYL DIPHENYL SILANYLOXY)BUTYL 2 URACIL ACETAMIDE; UNCLASSIFIED DRUG; URACIL ACETAMIDE DERIVATIVE; URACIL DERIVATIVE;

ANIMAL CELL; ARTICLE; BIOASSAY; BIOLOGICAL ACTIVITY; CELL DEATH; CELL LINE; CELL STRAIN L6; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HYDROGENATION; IC 50; IN VITRO STUDY; MOLECULAR MODEL; NONHUMAN; PLASMODIUM FALCIPARUM; RAT; SILYLATION;

ACETAMIDES; ANIMALS; DRUG DESIGN; ENZYME INHIBITORS; PLASMODIUM FALCIPARUM; PYROPHOSPHATASES; STRUCTURE-ACTIVITY RELATIONSHIP; URACIL;

EID: 60149107206     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.05.018     Document Type: Article

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