Molecular characterization of a novel geranylgeranyl pyrophosphate synthase from Plasmodium Parasites

Journal of Biological Chemistry

Volumn 286, Issue 5, 2011, Pages 3315-3322

  Artz, Jennifer D ^a   Wernimont, Amy K ^a   Dunford, James E ^b,c   Schapira, Matthieu ^a   Dong, Aiping ^a   Zhao, Yong ^a   Lew, Jocelyne ^a   Russell, R Graham G ^c   Ebetino, F Hal ^d   Oppermann, Udo ^b,c   Hui, Raymond ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c NIHR OXFORD BIOMEDICAL RESEARCH CENTRE   (United Kingdom)

^d PROCTER AND GAMBLE PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTATES; BIOCHEMICAL ASSAY; BISPHOSPHONATES; FARNESYL PYROPHOSPHATES; HYDROPHOBIC CAVITIES; MAGNESIUM ATOM; MOLECULAR CHARACTERIZATION; PLASMODIUM PARASITES; PLASMODIUM VIVAX; SYNTHASES;

AMINO ACIDS; HYDROPHOBICITY; MAGNESIUM; PLANTS (BOTANY); STRUCTURAL ANALYSIS;

YEAST;

ASPARTIC ACID; BISPHOSPHONIC ACID DERIVATIVE; FARNESYL TRANS TRANSFERASE; ENZYME INHIBITOR; GERANYLGERANYL PYROPHOSPHATE; ISOPRENOID PHOSPHATE; MAGNESIUM; NITROGEN; PHYTOENE SYNTHASE;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME STRUCTURE; ENZYME SYNTHESIS; HUMAN; NONHUMAN; PLASMODIUM VIVAX; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; STRUCTURE ANALYSIS; AMINO ACID SEQUENCE; BIOSYNTHESIS; CHEMICAL PHENOMENA; CHEMISTRY; DRUG ANTAGONISM; ENZYMOLOGY; IC 50; METABOLISM; PROTEIN MOTIF; YEAST;

EUKARYOTA; PLASMODIUM (APICOMPLEXA); PLASMODIUM PARASITES; PLASMODIUM VIVAX;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; DIPHOSPHONATES; ENZYME INHIBITORS; GERANYLGERANYL-DIPHOSPHATE GERANYLGERANYLTRANSFERASE; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; INHIBITORY CONCENTRATION 50; MAGNESIUM; NITROGEN; PLASMODIUM VIVAX; POLYISOPRENYL PHOSPHATES; YEASTS;

EID: 79952799000     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.027235     Document Type: Article

References (30)

1. Dunford, J. E., Kwaasi, A. A., Rogers, M. J., Barnett, B. L., Ebetino, F. H., Russell, R. G., Oppermann, U., and Kavanagh, K. L. (2008) J. Med. Chem. 51, 2187-2195
2. Dunford, J. E., Thompson, K., Coxon, F. P., Luckman, S. P., Hahn, F. M., Poulter, C. D., Ebetino, F. H., and Rogers, M. J. (2001) J. Pharmacol. Exp. Ther. 296, 235-242
3. Kavanagh, K. L., Guo, K., Dunford, J. E., Wu, X., Knapp, S., Ebetino, F. H., Rogers, M. J., Russell, R. G., and Oppermann, U. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 7829-7834
4. Ghosh, S., Chan, J. M., Lea, C. R., Meints, G. A., Lewis, J. C., Tovian, Z. S., Flessner, R. M., Loftus, T. C., Bruchhaus, I., Kendrick, H., Croft, S. L., Kemp, R. G., Kobayashi, S., Nozaki, T., and Oldfield, E. (2004) J. Med. Chem. 47, 175-187
5. Szabo, C. M., Matsumura, Y., Fukura, S., Martin, M. B., Sanders, J. M., Sengupta, S., Cieslak, J. A., Loftus, T. C., Lea, C. R., Lee, H. J., Koohang, A., Coates, R. M., Sagami, H., and Oldfield, E. (2002) J. Med. Chem. 45, 2185-2196
6. Guo, R. T., Cao, R., Liang, P. H., Ko, T. P., Chang, T. H., Hudock, M. P., Jeng, W. Y., Chen, C. K., Zhang, Y., Song, Y., Kuo, C. J., Yin, F., Oldfield, E., and Wang, A. H. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 10022-10027
7. Chang, T. H., Guo, R. T., Ko, T. P., Wang, A. H., and Liang, P. H. (2006) J. Biol. Chem. 281, 14991-15000
8. Kavanagh, K. L., Dunford, J. E., Bunkoczi, G., Russell, R. G., and Oppermann, U. (2006) J. Biol. Chem. 281, 22004-22012
9. Montalvetti, A., Bailey, B. N., Martin, M. B., Severin, G. W., Oldfield, E., and Docampo, R. (2001) J. Biol. Chem. 276, 33930-33937
10. Martin, M. B., Grimley, J. S., Lewis, J. C., Heath, H. T., 3rd, Bailey, B. N., Kendrick, H., Yardley, V., Caldera, A., Lira, R., Urbina, J. A., Moreno, S. N., Docampo, R., Croft, S. L., and Oldfield, E. (2001) J. Med. Chem. 44, 909-916
11. Gabelli, S. B., McLellan, J. S., Montalvetti, A., Oldfield, E., Docampo, R., and Amzel, L. M. (2006) Proteins 62, 80-88
12. Artz, J. D., Dunford, J. E., Arrowood, M. J., Dong, A., Chruszcz, M., Kavanagh, K. L., Minor, W., Russell, R. G., Ebetino, F. H., Oppermann, U., and Hui, R. (2008) Chem. Biol. 15, 1296-1306
13. Ling, Y., Sahota, G., Odeh, S., Chan, J. M., Araujo, F. G., Moreno, S. N., and Oldfield, E. (2005) J. Med. Chem. 48, 3130-3140
14. Moreno, B., Bailey, B. N., Luo, S., Martin, M. B., Kuhlenschmidt, M., Moreno, S. N., Docampo, R., and Oldfield, E. (2001) Biochem. Biophys. Res. Commun. 284, 632-637
15. Singh, A. P., Zhang, Y., No, J. H., Docampo, R., Nussenzweig, V., and Oldfield, E. (2010) Antimicrob. Agents Chemother. 54, 2987-2993
16. Ling, Y., Li, Z. H., Miranda, K., Oldfield, E., and Moreno, S. N. (2007) J. Biol. Chem. 282, 30804-30816
17. Bahl, A., Brunk, B., Crabtree, J., Fraunholz, M. J., Gajria, B., Grant, G. R., Ginsburg, H., Gupta, D., Kissinger, J. C., Labo, P., Li, L., Mailman, M. D., Milgram, A. J., Pearson, D. S., Roos, D. S., Schug, J., Stoeckert, C. J., Jr., and Whetzel, P. (2003) Nucleic Acids Res. 31, 212-215
18. Mukkamala, D., No, J. H., Cass, L. M., Chang, T. K., and Oldfield, E. (2008) J. Med. Chem. 51, 7827-7833
19. Vedadi, M., Lew, J., Artz, J., Amani, M., Zhao, Y., Dong, A., Wasney, G. A., Gao, M., Hills, T., Brokx, S., Qiu, W., Sharma, S., Diassiti, A., Alam, Z., Melone, M., Mulichak, A., Wernimont, A., Bray, J., Loppnau, P., Plotnikova, O., Newberry, K., Sundararajan, E., Houston, S., Walker, J., Tempel, W., Bochkarev, A., Kozieradzki, I., Edwards, A., Arrowsmith, C., Roos, D., Kain, K., and Hui, R. (2007) Mol. Biochem. Parasitol. 151, 100-110
20. Reed, B. C., and Rilling, H. C. (1975) Biochemistry 14, 50-54
21. Altschul, S. F., Gish, W., Miller, W., Myers, E. W., and Lipman, D. J. (1990) J. Mol. Biol. 215, 403-410
22. Chen, A., Kroon, P. A., and Poulter, C. D. (1994) Protein Sci. 3, 600-607
23. Ohnuma, S., Narita, K., Nakazawa, T., Ishida, C., Takeuchi, Y., Ohto, C., and Nishino, T. (1996) J. Biol. Chem. 271, 30748-30754
24. Tarshis, L. C., Proteau, P. J., Kellogg, B. A., Sacchettini, J. C., and Poulter, C. D. (1996) Proc. Natl. Acad. Sci. U.S.A. 93, 15018-15023
25. Tarshis, L. C., Yan, M., Poulter, C. D., and Sacchettini, J. C. (1994) Biochemistry 33, 10871-10877
26. Rondeau, J. M., Bitsch, F., Bourgier, E., Geiser, M., Hemmig, R., Kroemer, M., Lehmann, S., Ramage, P., Rieffel, S., Strauss, A., Green, J. R., and Jahnke, W. (2006) Chem. Med. Chem. 1, 267-273
27. Clastre, M., Goubard, A., Prel, A., Mincheva, Z., Viaud-Massuart, M. C., Bout, D., Rideau, M., Velge-Roussel, F., and Laurent, F. (2007) Exp. Parasitol. 116, 375-384
28. Chakrabarti, D., Da Silva, T., Barger, J., Paquette, S., Patel, H., Patterson, S., and Allen, C. M. (2002) J. Biol. Chem. 277, 42066-42073
29. Chakrabarti, D., Azam, T., DelVecchio, C., Qiu, L., Park, Y. I., and Allen, C. M. (1998) Mol. Biochem. Parasitol. 94, 175-184
30. Chen, K.-M., Hudock, M. P., Zhang, Y., Guo, R. T., Cao, R., No, J. H., Liang, P. H., Ko, T. P., Chang, T. H., Chang, S. C., Song, Y., Axelson, J., Kumar, A., Wang, A. H., and Oldfield, E. (2008) J. Med. Chem. 51, 5594-5607