Structures of falcipain-2 and falcipain-3 bound to small molecule inhibitors: Implications for substrate specificity

Journal of Medicinal Chemistry

Volumn 52, Issue 3, 2009, Pages 852-857

  Kerr, Iain D ^a   Lee, Ji H ^a,d   Pandey, Kailash C ^b   Harrison, Amanda ^b   Sajid, Mohammed ^c   Rosenthal, Philip J ^b   Brinen, Linda S ^a  

^a Department of Cellular and Molecular Pharmacology ^*  (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d CrystalGenomics Inc   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE PROTEINASE; FALCIPAIN 2; FALCIPAIN 3; LEUPEPTIN; N [N (3 CARBOXYOXIRANE 2 CARBONYL)LEUCYL]AGMATINE; PROTEIN INHIBITOR; PROTOZOAL PROTEIN; UNCLASSIFIED DRUG; CYSTEINE PROTEINASE INHIBITOR;

AMINO ACID SUBSTITUTION; ARTICLE; CHEMICAL REACTION KINETICS; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYME STRUCTURE; NONHUMAN; STRUCTURE ANALYSIS; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CRYSTALLIZATION; ENZYMOLOGY; KINETICS; PLASMODIUM FALCIPARUM; X RAY CRYSTALLOGRAPHY;

ANIMALS; CATALYTIC DOMAIN; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; KINETICS; LEUPEPTINS; MODELS, MOLECULAR; PLASMODIUM FALCIPARUM; SUBSTRATE SPECIFICITY;

EID: 61449267734     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm8013663     Document Type: Article

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