Plasmodium falciparum purine nucleoside phosphorylase: Crystal structures, immucillin inhibitors, and dual catalytic function

Journal of Biological Chemistry

Volumn 279, Issue 18, 2004, Pages 18103-18106

  Shi, Wuxian ^a   Ting, Li Min ^a   Kicska, Gregory A ^a   Lewandowicz, Andrzej ^a   Tyler, Peter C ^b   Evans, Gary B ^b   Furneaux, Richard H ^b   Kim, Kami ^a   Almo, Steve C ^a   Schramm, Vern L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b CALLAGHAN INNOVATION   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CRYSTAL STRUCTURE; HYDROPHILICITY; HYDROPHOBICITY; MALARIA CONTROL; METABOLISM;

ANTI-MALARIAL ACTION; DUAL CATALYTIC FUNCTION;

ENZYMES;

5' METHYLTHIOINOSINE; CARBON; HYDROXYL GROUP; IMMUCILLIN H; INOSINE DERIVATIVE; POLYAMINE; PURINE; PURINE NUCLEOSIDE PHOSPHORYLASE; PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITOR; SULFATE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CELL FUNCTION; CRYSTAL STRUCTURE; ENZYME ACTIVITY; HYDROPHILICITY; MALARIA; NONHUMAN; PLASMODIUM FALCIPARUM; POLYAMINE METABOLISM; PRIORITY JOURNAL;

ANIMALS; CATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; HYDROPHOBICITY; METHYLTHIOINOSINE; MOLECULAR STRUCTURE; PLASMODIUM FALCIPARUM; PURINE-NUCLEOSIDE PHOSPHORYLASE; PYRIMIDINONES; PYRROLES;

PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 2442431653     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.C400068200     Document Type: Article

References (18)

1. Reyes, P., Rathod, P. K., Sanchez, D. J., Mrema, J. E., Rieckmann, K. H., and Heidrich, H. G. (1982) Mol. Biochem. Parasitol. 5, 275-290
2. Kicska, G. A., Tyler, P. C., Evans, G. B., Furneaux, R. H., Schramm, V. L., and Kim, K. (2002) J. Biol. Chem. 277, 3226-3231
3. Asahi, H., Kanazawa, T., Kajihara, Y., Takahashi, K., and Takahasi, T. (1996) Parasitology 113, 19-23
4. Kicska, G. A., Tyler, P. C., Evans, G. B., Furneaux, R. H., Kim, K., and Schramm, V. L. (2002) J. Biol. Chem. 277, 3219-3225
5. Bzowska, A., Kulikowska, E., and Shugar, D. (2000) Pharmacol. Ther. 88, 349-425
6. Lewandowicz, A., and Schramm, V. L. (2004) Biochemistry 43, 1458-1468
7. Miles, R. W., Tyler, P. C., Furneaux, R. H., Bagdassarian, C. K., and Schramm, V. L. (1998) Biochemistry 37, 8615-8621
8. Evans, G. B., Furneaux, R. H., Hutchison, T. L., Kezer, H. S., Morris, P. E. Jr., Schramm, V. L., and Tyler, P. C. (2001) J. Org. Chem. 66, 5723-5730
9. Evans, G. B., Furneaux, R. H., Gainsford, G. J., Schramm, V. L., and Tyler, P. C. (2000) Tetrahedron 56, 3053-3062
10. Kikagawa, K., Iizuka, K., Higuchi, Y., Hirayama, H., and Ichino, M. (1972) J. Med. Chem. 15, 387-390
11. Mao, C., Cook, W. J., Zhou, M., Koszalka, G. W., Krenitsky, T. A., and Ealick, S. C. (1997) Structure (Lond.) 5, 1373-1383
12. Otwinowski, Z., and Minor, W. (1997) Methods Enzymol. 276, 307-326
13. Navaza, J. (1994) Acta Crystallogr. Sect. A 50, 157-163
14. Brunger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. Sect. D Biol. Crystallogr. 54, 905-921
15. Fedorov, A., Shi, W., Kicska, G., Fedorov, E., Tyler, P. C., Furneaux, R. H., Hanson, J. C., Gainsford, G. J., Larese, J. Z., Schramm, V. L., and Almo, S. C. (2001) Biochemistry 40, 853-860
16. Bennett, E. M., Li, C., Allan, P. W., Parker, W. B., and Ealick, S. E. (2003) J. Biol. Chem. 278, 47110-47118
17. Evans, S. V. (1998) J. Mol. Graph. 11, 134-138
18. Nicholls, A., Sharp, K., and Honig, B. (1991) Proteins Struct. Funct. Genet. 11, 281-296