Molecular basis for drug resistance in HIV-1 protease

Viruses

Volumn 2, Issue 11, 2010, Pages 2509-2535

  Ali, Akbar ^a   Bandaranayake, Rajintha M ^a   Cai, Yufeng ^a   King, Nancy M ^a   Kolli, Madhavi ^a   Mittal, Seema ^a   Murzycki, Jennifer F ^b   Nalam, Madhavi N L ^a   Nalivaika, Ellen A ^a   Özen, Ayşegül ^a   Prabu Jeyabalan, Moses M ^c   Thayer, Kelly ^a   Schiffer, Celia A ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^c Janet Weis Children s Hospital   (United States)

Author keywords

Drug resistance; HIV 1 protease; Protease inhibitors; Structure based drug design; Substrate envelope

Indexed keywords

AMPRENAVIR; ATAZANAVIR; DARUNAVIR; FOSAMPRENAVIR; GAG PROTEIN; INDINAVIR; LOPINAVIR; LOPINAVIR PLUS RITONAVIR; NELFINAVIR; POL PROTEIN; PROTEINASE; PROTEINASE INHIBITOR; RITONAVIR; SAQUINAVIR; TIPRANAVIR;

AMINO ACID SUBSTITUTION; ANTIVIRAL ACTIVITY; ANTIVIRAL RESISTANCE; ARTICLE; DRUG BIOAVAILABILITY; DRUG HALF LIFE; DRUG POTENCY; DRUG POTENTIATION; DRUG PROTEIN BINDING; DRUG SENSITIVITY; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SUBSTRATE; GENE MUTATION; GENETIC POLYMORPHISM; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; LOW DRUG DOSE; NONHUMAN; PROTEIN CLEAVAGE; STRUCTURE ACTIVITY RELATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 79952171610     PISSN: None     EISSN: 19994915     Source Type: Journal    
DOI: 10.3390/v2112509     Document Type: Article

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