Structural basis for catalytic and inhibitory mechanisms of β-hydroxyacyl-acyl carrier protein dehydratase (FabZ)

Journal of Biological Chemistry

Volumn 283, Issue 9, 2008, Pages 5370-5379

  Zhang, Liang ^a   Liu, Weizhi ^a   Hu, Tiancen ^a   Du, Li ^a   Luo, Cheng ^a   Chen, Kaixian ^a   Shen, Xu ^a,b   Jiang, Hualiang ^a,b  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDS; BINDING ENERGY; BIOCHEMICAL ENGINEERING; BIOCHEMISTRY; BIOSYNTHESIS; CIVIL AVIATION; CONFORMATIONS; FATTY ACIDS; PROTEINS; SUBSTRATES; TUNNELS; VEHICULAR TUNNELS;

ACTIVE SITES; ACYL CARRIER PROTEINS; ANTIBACTERIAL AGENTS; BINDING AFFINITIES; CATALYTIC ACTIVITIES; CATALYTIC MECHANISMS; CRYSTAL STRUCTURAL CHARACTERIZATIONS; ENZYMATIC ACTIVITIES; FATTY ACID BIOSYNTHESES; HELICOBACTER PYLORUS; INHIBITORY MECHANISMS; PATHOGENIC MICROBES; STRUCTURAL BASES; SUBSTRATE BINDINGS; TYPE II; UNSATURATED FATTY ACIDS;

CRYSTAL STRUCTURE;

ANTIINFECTIVE AGENT; BACTERIAL ENZYME; BETA HYDROXYACYL DERIVATIVE; CARRIER PROTEIN; ENZYME INHIBITOR; HYDROLYASE; PHENYLALANINE; PROTEIN FABZ; PROTEIN FABZ INHIBITOR; TYROSINE; UNCLASSIFIED DRUG; 3 HYDROXYDECANOYL (ACYL CARRIER PROTEIN) DEHYDRATASE; 3-HYDROXYDECANOYL-(ACYL-CARRIER-PROTEIN) DEHYDRATASE; BACTERIAL PROTEIN; FATTY ACID;

ALPHA HELIX; ARTICLE; BINDING AFFINITY; CATALYSIS; CRYSTAL STRUCTURE; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME STRUCTURE; FATTY ACID SYNTHESIS; HELICOBACTER PYLORI; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STRUCTURE; AMINO ACID SUBSTITUTION; BINDING SITE; BIOSYNTHESIS; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; MISSENSE MUTATION; PHYSIOLOGY; PROTEIN SECONDARY STRUCTURE; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

BACTERIA (MICROORGANISMS); HELICOBACTER PYLORI;

AMINO ACID SUBSTITUTION; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; FATTY ACIDS; HELICOBACTER PYLORI; HYDRO-LYASES; MUTATION, MISSENSE; PROTEIN STRUCTURE, SECONDARY; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 41949086428     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M705566200     Document Type: Article

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