Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 31, 2006, Pages 11503-11508

  Wang, Stephanie X ^a   Pandey, Kailash C ^b   Somoza, John R ^d   Sijwali, Puran S ^b   Kortemme, Tanja ^c   Brinen, Linda S ^a   Fletterick, Robert J ^b   Rosenthal, Philip J ^b   McKerrow, James H ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d CELERA   (United States)

Author keywords

Cysteine protease; Falcipain 2; Inhibitor; Malaria; X ray structure

Indexed keywords

CYSTATIN; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; FALCIPAIN 2; GLUTAMIC ACID; HEMOGLOBIN; HEMOGLOBIN HYDROXYLASE; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME STRUCTURE; GENETIC CONSERVATION; HUMAN; MALARIA; MUTAGENESIS; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN MOTIF; X RAY ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; CRYSTALLOGRAPHY, X-RAY; CYSTATINS; CYSTEINE ENDOPEPTIDASES; HEMOGLOBINS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PLASMODIUM FALCIPARUM; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID;

PLASMODIUM FALCIPARUM;

EID: 33746791205     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0600489103     Document Type: Article

References (29)

1. White, N. J. (2004) J. Clin. Invest. 113, 1084-1092,
2. Francis, S. E., Sullivan, D. J., Jr., & Goldberg, D. E. (1997) Amu. Rev. Microbiol. 51, 97-123.
3. Lew, V. L., Tiffert, T. & Ginsburg, H. (2003) Blood 101, 4189-4194.
4. Semenov, A., Olson, J. E. & Rosenthal, P. J. (1998) Antimicrob. Agents Chemother. 42, 2254-2258.
5. Francis, S. E., Gluzman, I. Y., Oksman, A., Knickerbocker, A., Mueller, R., Bryant, M. L., Sherman, D. R., Russell, D. G. & Goldberg, D. E. (1994) EMBO J. 13, 306-317.
6. Rosenthal, P. J., Wollish, W. S., Palmer, J. T. & Rasnick, D. (1991) J. Clin. Invest. 88, 1467-1472.
7. Shenai, B. R., Sijwali, P. S., Singh, A. & Rosenthal, P.J. (2000) J. Biol. Chem. 275, 29000-29010.
8. Sijwali, P. S., Shenai, B. R., Gut, J., Singh, A. & Rosenthal, P. J. (2001) Biochem. J. 360, 481-489.
9. Sijwali, P. S. & Rosenthal, P. J. (2004) Proc. Natl. Acad. Sci. USA 101, 4384-4389.
10. Shenai, B. R., Lee, B. J., Alvarez-Hernandez, A., Chong, P. Y., Emal, C. D., Neitz, R. J., Roush, W. R. & Rosenthal, P. J. (2003) Antimicrob. Agents Chemother. 47, 154-160.
11. Rosenthal, P. J., Lee, G. K. & Smith, R. E. (1993) J. Clin. Invest. 91, 1052-1056.
12. Olson, J. E., Lee, G. K., Semenov, A. & Rosenthal, P. J. (1999) Bioorg. Med. Chem. 7, 633-638.
13. Sijwali, P. S., Shenai, B. R. & Rosenthal, P. J. (2002) J. Biol. Chem. 277, 14910-14915.
14. Pandey, K. C. Sijwali, P. S., Singh, A., Na, B. K. & Rosenthal, P. J. (2004) J. Biol. Chem. 279, 3484-3491.
15. Sabnis, Y., Rosenthal, P. J., Desai, P. & Avery, M. A. (2002) J. Biomol. Struct. Dyn. 19, 765-774.
16. Goh, L. L. & Sim, T. S. (2004) Biochem. Biophys. Res. Commun. 323, 565-572.
17. Sijwali, P. S., Brinen, L. S. & Rosenthal, P. J. (2001) Protein Expr. Purif. 22, 128-134.
18. Bode, W., Engh, R., Musil, D., Thiele, U., Huber, R., Karshikov, A., Brzin, J., Kos, J. & Turk, V. (1988) EMBO J. 7, 2593-2599.
19. Stubbs, M. T., Laber, B., Bode, W., Huber, R., Jerala, R., Lenarcic, B. & Turk, V. (1990) EMBO J. 9, 1939-1947.
20. Jenko, S., Dolenc, I., Guncar, G., Dobersek, A., Podobnik, M. & Turk, D. (2003) J. Mol. Biol. 326, 875-885.
21. Kamphuis, I. G., Drenth, J. & Baker, E. N. (1985) J. Mol. Biol. 182, 317-329.
22. Pandey, K. C., Wang, S. X., Sijwali, P. S., Lau, A. L., McKerrow, J. H. & Rosenthal, P. J. (2005) Proc. Natl. Acad. Sci. USA 102, 9138-9143.
23. Schechtet, I. & Berger, A. (1967) Biochem. Biophys. Res. Commun. 27, 157-162.
24. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254.
25. Ho, S. N., Hunt, H. D., Horton, R. M., Pullen, J. K. & Pease, L. R. (1989) Gene 77, 51-59.
26. Otwinowski, Z. & Minor, W. (1997) Processing of X-Ray Diffraction Data Collected in Oscillation Mode (Academic, New York).
27. Brunger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., et al. (1998) Acta Crystallogr. D 54, 905-921.
28. Nicholls, A., Sharp, K. A. & Honig, B. (1991) Proteins II, 281-296.
29. Thompson, J. D., Higgins, D. G. & Gibson, T. J. (1994) Nucleic Acids Res. 22, 4673-4680.