Purine-less death in Plasmodium falciparum induced by immucillin-H, a transition state analogue of purine nucleoside phosphorylase

Journal of Biological Chemistry

Volumn 277, Issue 5, 2002, Pages 3226-3231

  Kicska, Gregory A ^a   Tyler, Peter C ^a,c   Evans, Gary B ^a,b   Furneaux, Richard H ^a   Schramm, Vern L ^c,d   Kim, Kami ^a,d  

^a Departments of Biochemistry   (United States)

^b Division of Infectious Diseases   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d CALLAGHAN INNOVATION   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; ENZYME INHIBITION; ENZYMES; MICROORGANISMS; NUCLEIC ACIDS; TITRATION;

GROWTH INHIBITION;

BIOCHEMISTRY;

HYPOXANTHINE; IMMUCILLIN H; INOSINE; NUCLEIC ACID; PURINE; PURINE NUCLEOSIDE PHOSPHORYLASE; PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; ARTICLE; DRUG SPECIFICITY; DRUG STRUCTURE; ENZYME INHIBITION; ERYTHROCYTE; GROWTH INHIBITION; HEMATOCRIT; IC 50; MALARIA; MICROBIAL GROWTH; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PURINE SYNTHESIS; SURVIVAL;

ANIMALS; BIOLOGICAL TRANSPORT; CELL DEATH; ENZYME INHIBITORS; ERYTHROCYTES; HUMANS; HYPOXANTHINE; KINETICS; MODELS, BIOLOGICAL; PLASMODIUM FALCIPARUM; PURINE-NUCLEOSIDE PHOSPHORYLASE; PURINES; PYRIMIDINONES; PYRROLES; TIME FACTORS;

MAMMALIA; PLASMODIUM FALCIPARUM;

EID: 0036479245     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M105906200     Document Type: Article

References (30)