Plasmodium subtilisin-like protease 1 (SUB1): Insights into the active-site structure, specificity and function of a pan-malaria drug target

International Journal for Parasitology

Volumn 42, Issue 6, 2012, Pages 597-612

  Withers Martinez, Chrislaine ^a   Suarez, Catherine ^a   Fulle, Simone ^b   Kher, Samir ^c   Penzo, Maria ^a   Ebejer, Jean Paul ^b   Koussis, Kostas ^a   Hackett, Fiona ^a   Jirgensons, Aigars ^c   Finn, Paul ^b   Blackman, Michael J ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b INHIBOX LTD   (United Kingdom)

^c LATVIAN INSTITUTE OF ORGANIC SYNTHESIS   (Latvia)

Author keywords

Alpha ketoamide; Plasmodium; SUB1; Substrate specificity; Subtilisin

Indexed keywords

PLASMODIUM SUBTILISIN LIKE PROTEASE 1; PROTEINASE; SUBTILISIN; UNCLASSIFIED DRUG;

LIFE CYCLE; MALARIA; MATURATION; PARASITE; PATHOGEN; RODENT; SUBSTRATE;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SPECIFICITY; MOLECULAR DYNAMICS; NONHUMAN; PLASMODIUM BERGHEI; PLASMODIUM KNOWLESI; PLASMODIUM VIVAX; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION;

ANTIMALARIALS; CATALYTIC DOMAIN; HUMANS; MODELS, MOLECULAR; PLASMODIUM; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PLASMODIUM KNOWLESI; PLASMODIUM VIVAX; PROTEASE INHIBITORS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTOZOAN PROTEINS; SUBSTRATE SPECIFICITY; SUBTILISINS;

PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PLASMODIUM KNOWLESI; PLASMODIUM VIVAX; RODENTIA;

EID: 84861678443     PISSN: 00207519     EISSN: 18790135     Source Type: Journal    
DOI: 10.1016/j.ijpara.2012.04.005     Document Type: Article

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