Neighboring group participation in the transition state of human purine nucleoside phosphorylase

Biochemistry

Volumn 46, Issue 17, 2007, Pages 5038-5049

  Murkin, Andrew S ^a   Birck, Matthew R ^a,b   Rinaldo Matthis, Agnes ^a   Shi, Wuxian ^a,c   Taylor, Erika A ^a   Almo, Steven C ^a   Schramm, Vern L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b Barnard College of Columbia University   (United States)

^c BROOKHAVEN NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CRYSTAL STRUCTURE; HYDROGEN BONDS; ISOTOPES; MUTAGENESIS;

KINETIC ISOTOPE EFFECT (KIE); MICHAELIS COMPLEX; MUTATION; NUCLEOSIDES; TRANSITION STATES; X-RAY CRYSTAL STRUCTURES;

ENZYMES;

ARSENIC; ASPARTIC ACID; HISTIDINE; HYDROXYL GROUP; IMMUCILLIN H; PHENYLALANINE; PURINE NUCLEOSIDE PHOSPHORYLASE;

ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; ENZYME KINETICS; ENZYME MECHANISM; HYDROGEN BOND; MUTANT; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

BASE SEQUENCE; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; DNA PRIMERS; HUMANS; KINETICS; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PURINE-NUCLEOSIDE PHOSPHORYLASE;

EID: 34247603923     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi700147b     Document Type: Article

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