Triclosan offers protection against blood stages of malaria by inhibiting enoyl-ACP reductase of Plasmodium falciparum

Nature Medicine

Volumn 7, Issue 2, 2001, Pages 167-173

  Surolia, Namita ^a   Surolia, Avadhesha ^b  

^a JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH   (India)

^b INDIAN INSTITUTE OF SCIENCE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; ACYL CARRIER PROTEIN; ANTIMALARIAL AGENT; CARBON 14; CERULENIN; CHLOROQUINE; ENOYL ACYL CARRIER PROTEIN REDUCTASE; MALONYL COENZYME A; NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TRICLOSAN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; ENZYME INHIBITION; FATTY ACID SYNTHESIS; GROWTH INHIBITION; LIFE CYCLE; MALARIA; MOUSE; NONHUMAN; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; ANTIMALARIALS; DISEASE MODELS, ANIMAL; ENOYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (NADH); FATTY ACIDS; MALARIA; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; NAD; OXIDOREDUCTASES; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; TRICLOSAN;

ANIMALIA; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 0035126479     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/84612     Document Type: Article

References (40)

1. Escherichia coli as a model for the regulation of dissociable (type II) fatty acid biosynthesis
2. Studies on the mechanism of fatty acid synthesis
3. EnvM genes of Salmonella typhimurium and Escherichia coli
4. Protein EnvM is the NADH-dependent enoyl-ACP reductase (FabI) of Escherichia coli
5. Enoyl-acyl carrier protein reductase (FabI) plays a determinant role in completing cycles of fatty acid elongation in Escherichia coli
6. Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum
7. Triclosan targets lipid synthesis
8. Broad spectrum antimicrobial biocides target the FabI component of fatty acid synthesis
9. Mechanism of triclosan inhibition of bacterial fatty acid synthesis
10. Inhibition of fatty acid synthetases by the antibiotic cerulenin
11. The cloning and expression of pfacs1, a Plasmodium falciparum fatty acid coenzyme A synthetase-1 targeted to the host erythrocyte cytoplasm
12. Acylation of a Plasmodium falciparum merozoite surface antigen via sn-1,2-diacyl glycerol
13. Lipids and the malarial parasite
14. The enoyl-[acyl-carrier-protein] reductase (FabI) of Escherichia coli, which catalyzes a key regulatory step in fatty acid biosynthesis, accepts NADH and NADPH as cofactors and is inhibited by palmitoyl-CoA
15. cDNA cloning and expression of Brassica napus enoyl-acyl carrier protein reductase in Escherichia coli
16. Molecular basis of triclosan activity
17. Inhibition of Plasmodium falciparum protein synthesis. Targeting the plastid-like organelle with thiostrepton
18. Molecular biology and pathogenicity of mycoplasmas
19. The minimal gene complement of Mycoplasma genitalium
20. Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae
21. Functional drug targeting to erythrocytes in vivo using antibody bearing liposomes as drug vehicles
22. Lysis of Plasmodium falciparum by ferriprotoporphyrin IX and a chloroquine-ferriprotoporphyrin IX complex
23. Chloroquine inhibits heme-dependent protein synthesis in Plasmodium falciparum
24. Inhibitors of nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs
25. Triclosan application and safety
26. Human malaria parasites in continuous culture
27. Implications of mycoplasma contamination in Plasmodium falciparum cultures and methods for its detection and eradication
28. Rapid, sensitive PCR-based detection of mycoplasmas in simulated samples of animal sera
29. Synchronization of Plasmodium falciparum erythrocytic stages in culture
30. De nova biosynthesis of heme offers a new chemotherapeutic target in the human malarial parasite
31. Antimalarial activity of 77 phospholipid polar head analogs: Close correlation between inhibition of phospholipid metabolism and in vitro Plasmodium falciparum growth
32. Dunnschich chromatographic von fettsauren auf silanisiertem kiesel gel
33. Induction, purification and characterization of NADH-specific enoyl acyl carrier protein reductase from developing seeds of oil seed rape (Brassica napus)
34. Purification and characterization of the stearoyl-acyl carrier protein desaturase and the acyl-acyl carrier protein thioesterase from maturing seeds of safflower
35. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
36. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
37. Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction