Discovery of plasmodium vivax N -myristoyltransferase inhibitors: Screening, synthesis, and structural characterization of their binding mode

Journal of Medicinal Chemistry

Volumn 55, Issue 7, 2012, Pages 3578-3582

  Goncalves, Victor ^a   Brannigan, James A ^b   Whalley, David ^c   Ansell, Keith H ^c   Saxty, Barbara ^c   Holder, Anthony A ^d   Wilkinson, Anthony J ^b   Tate, Edward W ^a   Leatherbarrow, Robin J ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF YORK   (United Kingdom)

^c MEDICAL RESEARCH COUNCIL   (United Kingdom)

^d NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; PROTEIN N MYRISTOYLTRANSFERASE INHIBITOR;

ANTIMALARIAL ACTIVITY; ARTICLE; BINDING KINETICS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ACYLTRANSFERASES; ANTIMALARIALS; CRYSTALLOGRAPHY, X-RAY; HUMANS; ISOENZYMES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PLASMODIUM VIVAX; PROTEIN BINDING; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84859790956     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300040p     Document Type: Article

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