Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity

Journal of Medicinal Chemistry

Volumn 56, Issue 6, 2013, Pages 2513-2526

  Keough, Dianne T ^a   Špaček, Petr ^b   Hocková, Dana ^b   Tichý, Tomáš ^b   Vrbková, Silvie ^b   Slavětínská, Lenka ^b   Janeba, Zlatko ^b   Naesens, Lieve ^c   Edstein, Michael D ^d   Chavchich, Marina ^d   Wang, Tzu Hsuan ^a   De Jersey, John ^a   Guddat, Luke W ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^d AUSTRALIAN ARMY MALARIA INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

[[[2 ((GUANINE 9H YL)METHYL)PROPANE 1,3 DIYL]BIS(OXY)]BIS(METHYLENE)]DIPHOSPHONIC ACID; ACYCLIC NUCLEOSIDE PHOSPHONATE; ANTIMALARIAL AGENT; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; PHOSPHONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; BINDING SITE; CELL CULTURE; CHEMICAL MODIFICATION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; HUMAN; HUMAN CELL; IC 50; PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX;

ANTIMALARIALS; CATALYTIC DOMAIN; CELL LINE, TUMOR; ENZYME INHIBITORS; HUMANS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MODELS, MOLECULAR; ORGANOPHOSPHONATES; PLASMODIUM FALCIPARUM;

EID: 84875691966     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301893b     Document Type: Article

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