The 2.0 Å structure of malarial purine phosphoribosyltransferase in complex with a transition-state analogue inhibitor

Biochemistry

Volumn 38, Issue 31, 1999, Pages 9872-9880

  Shi, Wuxian ^a   Li, Caroline M ^a   Tyler, Peter C ^b   Furneaux, Richard H ^b   Cahill, Sean M ^a   Girvin, Mark E ^a   Grubmeyer, Charles ^c   Schramm, Vern L ^a   Almo, Steven C ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b CALLAGHAN INNOVATION   (New Zealand)

^c TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MAGNESIUM ION; PURINE NUCLEOSIDE PHOSPHORYLASE; PYROPHOSPHATE; ENZYME INHIBITOR; GLYCOSYLTRANSFERASE; HYPOXANTHINE GUANINE XANTHINE PHOSPHORIBOSYLTRANSFERASE; HYPOXANTHINE-GUANINE-XANTHINE PHOSPHORIBOSYLTRANSFERASE; IMMUCILLIN H; PROTON; PYRIMIDINONE DERIVATIVE; PYRROLE DERIVATIVE;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBUNIT; HYDROGEN BOND; MALARIA; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN FOLDING; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; DRUG ANTAGONISM; ENZYMOLOGY; HUMAN; MACROMOLECULE; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

ANIMALS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PENTOSYLTRANSFERASES; PLASMODIUM FALCIPARUM; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTONS; PYRIMIDINONES; PYRROLES;

EID: 0033519996     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi990664p     Document Type: Article

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