Synthesis of β- and γ-oxa isosteres of fosmidomycin and FR900098 as antimalarial candidates

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 6, 2008, Pages 3361-3371

  Haemers, Timothy ^a   Wiesner, Jochen ^b   Gießmann, Dirk ^c   Verbrugghen, Thomas ^a   Hillaert, Ulrik ^a   Ortmann, Regina ^d   Jomaa, Hassan ^b   Link, Andreas ^c   Schlitzer, Martin ^d   Van Calenbergh, Serge ^a  

^a GHENT UNIVERSITY   (Belgium)

^b UNIVERSITY HOSPITAL GIESSEN   (Germany)

^c UNIVERSITY OF GREIFSWALD   (Germany)

^d PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

DOXP reductoisomerase; Fosmidomycin; Isoprenoid biosynthesis; Methylerythritol phosphate pathway

Indexed keywords

2 (N HYDROXY N METHYLCARBONYLOXY)ETHYLPHOSPHONIC ACID; 2 (N HYDROXYCARBONYLOXY)ETHYLPHOSPHONIC ACID; 3 (N ACETYL N HYDROXYAMINO)PROPYLPHOSPHONIC ACID; ANTIMALARIAL AGENT; BIS(PIVALOYLOXYMETHYL)ESTER; CARBENE; FOSMIDOMYCIN; HYDROXAMIC ACID; OXYGEN; PHOSPHONIC ACID DERIVATIVE; UNCLASSIFIED DRUG; [(HYDROXYCARBAMOYL)METHOXY]METHYLPHOSPHONIC ACID; [(N HYDROXY N METHYLCARBAMOYL)METHOXY]METHYLPHOSPHONIC ACID; [N (N HYDROXYACETAMIDO)METHOXY]METHYLPHOSPHONIC ACID; [N (N HYDROXYFORMAMIDO)METHOXY]METHYLPHOSPHONIC ACID;

ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION;

PLASMODIUM FALCIPARUM;

EID: 40949137369     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.12.001     Document Type: Article

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