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Volumn 6, Issue 10, 2011, Pages 1816-1831
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Design, Synthesis, and Evaluation of 5′-Diphenyl Nucleoside Analogues as Inhibitors of the Plasmodium falciparum dUTPase
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MEDIVIR AB
(Sweden)
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Author keywords
Antiprotozoal agents; Drug design; DUTPase; Malaria; Nucleosides
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Indexed keywords
1 [3 (BENZHYDRYLAMINO)PROPYL]URACIL;
1 [4 (4,4' DIFLUOROBENZHYDRYLOXY)BUTYL]URACIL;
1 [4 (BENZHYDRYLAMINO)BUTYL]URACIL;
1 [4 (BENZHYDRYLOXY)BUTYL]URACIL;
5' (2,2 DIPHENYLETHYLAMINO) 2',5' DIDEOXYURIDINE;
5' (BENZHYDRYLAMINO) 2',5' DIDEOXYURIDINE;
5' (N ETHYLBENZHYDRYLAMINO) 2',5' DIDEOXYURIDINE;
5' (N METHYLBENZHYDRYLAMINO) 2',5' DIDEOXYURIDINE;
5' [2 (1 METHYL 1H IMIDAZOLE 2 YL) 2 PHENYLETHYLAMINO] 2',5' DIDEOXYURIDINE;
5' [BIS(4 FLUOROPHENYL)METHYLAMINO] 2',5' DIDEOXYURIDINE;
5' [PHENYL(THIAZOLE 2 YL)METHYLAMINO] 2' DEOXYURIDINE;
BIPHENYL DERIVATIVE;
DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE;
ENZYME INHIBITOR;
METHYLAMINE;
UNCLASSIFIED DRUG;
ANIMAL CELL;
ARTICLE;
BINDING SITE;
CONTROLLED STUDY;
CRYSTAL STRUCTURE;
CYTOTOXICITY TEST;
DRUG BINDING;
DRUG DESIGN;
DRUG SCREENING;
DRUG SOLUBILITY;
DRUG SYNTHESIS;
IN VITRO STUDY;
LIPOPHILICITY;
MOLECULAR WEIGHT;
NONHUMAN;
PLASMODIUM FALCIPARUM;
PRIORITY JOURNAL;
RAT;
STRUCTURE ACTIVITY RELATION;
BINDING SITES;
BIPHENYL COMPOUNDS;
CATALYTIC DOMAIN;
CRYSTALLOGRAPHY, X-RAY;
DRUG DESIGN;
ENZYME INHIBITORS;
HUMANS;
NUCLEOSIDES;
PLASMODIUM FALCIPARUM;
PYROPHOSPHATASES;
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EID: 80053422180
PISSN: 18607179
EISSN: 18607187
Source Type: Journal
DOI: 10.1002/cmdc.201100255 Document Type: Article |
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Times cited : (30)
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References (16)
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