Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach

Nature Chemistry

Volumn 6, Issue 2, 2014, Pages 112-121

  Wright, Megan H ^a   Clough, Barbara ^b   Rackham, Mark D ^a   Rangachari, Kaveri ^b   Brannigan, James A ^c   Grainger, Munira ^b   Moss, David K ^b   Bottrill, Andrew R ^d   Heal, William P ^a,f   Broncel, Malgorzata ^a   Serwa, Remigiusz A ^a   Brady, Declan ^e   Mann, David J ^a   Leatherbarrow, Robin J ^a,g   Tewari, Rita ^e   Wilkinson, Anthony J ^c   Holder, Anthony A ^b   Tate, Edward W ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^c UNIVERSITY OF YORK   (United Kingdom)

^d UNIVERSITY OF LEICESTER   (United Kingdom)

^e UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^f KING'S COLLEGE LONDON   (United Kingdom)

^g LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A; ACYLTRANSFERASE; ANTIMALARIAL AGENT; BIOMIMETIC MATERIAL; CAPRIN1 PROTEIN, HUMAN; CELL CYCLE PROTEIN; ENZYME INHIBITOR; GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE; PROTEIN N MYRISTOYLTRANSFERASE; RECOMBINANT PROTEIN; S TETRADECANOYL COENZYME A; S-TETRADECANOYL-COENZYME A;

ANIMAL; ARTICLE; BINDING SITE; BIOSYNTHESIS; CHEMISTRY; CYCLOADDITION; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; ENZYME SPECIFICITY; GENETICS; HUMAN; MALARIA; METABOLISM; MOLECULAR DOCKING; PARASITOLOGY; PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

ACYL COENZYME A; ACYLTRANSFERASES; ANIMALS; ANTIMALARIALS; BINDING SITES; BIOMIMETIC MATERIALS; CELL CYCLE PROTEINS; CRYSTALLOGRAPHY, X-RAY; CYCLOADDITION REACTION; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; HUMANS; MALARIA; MOLECULAR DOCKING SIMULATION; PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

EID: 84892956192     PISSN: 17554330     EISSN: 17554349     Source Type: Journal    
DOI: 10.1038/nchem.1830     Document Type: Article

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