메뉴 건너뛰기




Volumn 13, Issue 18, 2008, Pages 6966-6990

DNA repair, insulin signaling and sirtuins: At the crossroads between cancer and aging

Author keywords

Cancer; DNA Damage; DNA repair; Genomic Instability; Insulin Signaling; Lifespan; Metabolic Homeostasis; Review; SIRT6; Sirtuins

Indexed keywords

INSULIN; REACTIVE OXYGEN METABOLITE; SIRTUIN; SOMATOMEDIN C;

EID: 52049112965     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/3203     Document Type: Article
Times cited : (13)

References (231)
  • 1
    • 34547941973 scopus 로고    scopus 로고
    • The common biology of cancer and ageing
    • DOI 10.1038/nature05985, PII NATURE05985
    • Finkel, T., M. Serrano & M. A. Blasco: The common biology of cancer and ageing. Nature, 448, 767-74 (2007) (Pubitemid 47266334)
    • (2007) Nature , vol.448 , Issue.7155 , pp. 767-774
    • Finkel, T.1    Serrano, M.2    Blasco, M.A.3
  • 3
    • 34547875773 scopus 로고    scopus 로고
    • Sirtuins: Critical regulators at the crossroads between cancer and aging
    • DOI 10.1038/sj.onc.1210616, PII 1210616
    • Saunders, L. R. & E. Verdin: Sirtuins: critical regulators at the crossroads between cancer and aging. Oncogene, 26, 5489-504 (2007) (Pubitemid 47255930)
    • (2007) Oncogene , vol.26 , Issue.37 , pp. 5489-5504
    • Saunders, L.R.1    Verdin, E.2
  • 4
    • 13944249618 scopus 로고    scopus 로고
    • DNA repair, genome stability, and aging
    • DOI 10.1016/j.cell.2005.01.028
    • Lombard, D. B., K. F. Chua, R. Mostoslavsky, S. Franco, M. Gostissa & F. W. Alt: DNA repair, genome stability, and aging. Cell, 120, 497-512 (2005) (Pubitemid 40269764)
    • (2005) Cell , vol.120 , Issue.4 , pp. 497-512
    • Lombard, D.B.1    Chua, K.F.2    Mostoslavsky, R.3    Franco, S.4    Gostissa, M.5    Alt, F.W.6
  • 6
    • 33750704608 scopus 로고    scopus 로고
    • Five repair pathways in one context: Chromatin modification during DNA repair
    • DOI 10.1139/O06-075
    • Ataian, Y. & J. E. Krebs: Five repair pathways in one context: chromatin modification during DNA repair. Biochem Cell Biol, 84, 490-504 (2006) (Pubitemid 44703653)
    • (2006) Biochemistry and Cell Biology , vol.84 , Issue.4 , pp. 490-504
    • Ataian, Y.1    Krebs, J.E.2
  • 7
    • 0035902108 scopus 로고    scopus 로고
    • Genome maintenance mechanisms for preventing cancer
    • DOI 10.1038/35077232
    • Hoeijmakers, J. H.: Genome maintenance mechanisms for preventing cancer. Nature, 411, 366-74 (2001) (Pubitemid 32467046)
    • (2001) Nature , vol.411 , Issue.6835 , pp. 366-374
    • Hoeijmakers, J.H.J.1
  • 8
    • 33747376928 scopus 로고    scopus 로고
    • DNA repair pathways in clinical practice: Lessons from pediatric cancer susceptibility syndromes
    • DOI 10.1200/JCO.2005.05.4171
    • Kennedy, R. D. & A. D. D'Andrea: DNA repair pathways in clinical practice: lessons from pediatric cancer susceptibility syndromes. J Clin Oncol, 24, 3799-808 (2006) (Pubitemid 46622318)
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.23 , pp. 3799-3808
    • Kennedy, R.D.1    D'Andrea, A.D.2
  • 9
    • 0034707047 scopus 로고    scopus 로고
    • The DNA damage response: Putting checkpoints in perspective
    • Zhou, B. B. & S. J. Elledge: The DNA damage response: putting checkpoints in perspective. Nature, 408, 433-9 (2000)
    • (2000) Nature , vol.408 , pp. 433-439
    • Zhou, B.B.1    Elledge, S.J.2
  • 10
    • 34250820438 scopus 로고    scopus 로고
    • Chromatin dynamics and the preservation of genetic information
    • DOI 10.1038/nature05980, PII NATURE05980
    • Downs, J. A., M. C. Nussenzweig & A. Nussenzweig: Chromatin dynamics and the preservation of genetic information. Nature, 447, 951-8 (2007) (Pubitemid 46975762)
    • (2007) Nature , vol.447 , Issue.7147 , pp. 951-958
    • Downs, J.A.1    Nussenzweig, M.C.2    Nussenzweig, A.3
  • 11
    • 3242881500 scopus 로고    scopus 로고
    • The cellular response to general and programmed DNA double strand breaks
    • DOI 10.1016/j.dnarep.2004.06.001, PII S1568786404001752
    • Bassing, C. H. & F. W. Alt: The cellular response to general and programmed DNA double strand breaks. DNA Repair (Amst), 3, 781-96 (2004) (Pubitemid 38997922)
    • (2004) DNA Repair , vol.3 , Issue.8-9 , pp. 781-796
    • Bassing, C.H.1    Alt, F.W.2
  • 12
    • 3242891189 scopus 로고    scopus 로고
    • The Mre11 complex and the metabolism of chromosome breaks: The importance of communicating and holding things together
    • DOI 10.1016/j.dnarep.2004.03.014, PII S1568786404000734
    • Stracker, T. H., J. W. Theunissen, M. Morales & J. H. Petrini: The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together. DNA Repair (Amst), 3, 845-54 (2004) (Pubitemid 38997926)
    • (2004) DNA Repair , vol.3 , Issue.8-9 , pp. 845-854
    • Stracker, T.H.1    Theunissen, J.-W.F.2    Morales, M.3    Petrini, J.H.J.4
  • 13
    • 0345276495 scopus 로고    scopus 로고
    • Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair
    • DOI 10.1016/S1097-2765(03)00424-6
    • Dong, Y., M. A. Hakimi, X. Chen, E. Kumaraswamy, N. S. Cooch, A. K. Godwin & R. Shiekhattar: Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair. Mol Cell, 12, 1087-99 (2003) (Pubitemid 37487920)
    • (2003) Molecular Cell , vol.12 , Issue.5 , pp. 1087-1099
    • Dong, Y.1    Hakimi, M.-A.2    Chen, X.3    Kumaraswamy, E.4    Cooch, N.S.5    Godwin, A.K.6    Shiekhattar, R.7
  • 14
    • 34249950879 scopus 로고    scopus 로고
    • Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response
    • DOI 10.1126/science.1139621
    • Kim, H., J. Chen & X. Yu: Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response. Science, 316, 1202-5 (2007) (Pubitemid 46877484)
    • (2007) Science , vol.316 , Issue.5828 , pp. 1202-1205
    • Kim, H.1    Chen, J.2    Yu, X.3
  • 15
    • 34249949779 scopus 로고    scopus 로고
    • RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites
    • DOI 10.1126/science.1139516
    • Sobhian, B., G. Shao, D. R. Lilli, A. C. Culhane, L. A. Moreau, B. Xia, D. M. Livingston & R. A. Greenberg: RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites. Science, 316, 1198-202 (2007) (Pubitemid 46877483)
    • (2007) Science , vol.316 , Issue.5828 , pp. 1198-1202
    • Sobhian, B.1    Shao, G.2    Lilli, D.R.3    Culhane, A.C.4    Moreau, L.A.5    Xia, B.6    Livingston, D.M.7    Greenberg, R.A.8
  • 16
    • 34249946686 scopus 로고    scopus 로고
    • Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response
    • DOI 10.1126/science.1139476
    • Wang, B., S. Matsuoka, B. A. Ballif, D. Zhang, A. Smogorzewska, S. P. Gygi & S. J. Elledge: Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Science, 316, 1194-8 (2007) (Pubitemid 46877482)
    • (2007) Science , vol.316 , Issue.5828 , pp. 1194-1198
    • Wang, B.1    Matsuoka, S.2    Ballif, B.A.3    Zhang, D.4    Smogorzewska, A.5    Gygi, S.P.6    Elledge, S.J.7
  • 17
    • 0036240127 scopus 로고    scopus 로고
    • The mechanism and regulation of chromosomal v (D)J recombination
    • Bassing, C. H., W. Swat & F. W. Alt: The mechanism and regulation of chromosomal V (D)J recombination. Cell, 109 Suppl, S45-55 (2002)
    • (2002) Cell , vol.109 SUPPL
    • Bassing, C.H.1    Swat, W.2    Alt, F.W.3
  • 19
    • 34249685474 scopus 로고    scopus 로고
    • Length-dependent binding of human XLF to DNA and stimulation of XRCC4DNA ligase IV activity
    • DOI 10.1074/jbc.M609904200
    • Lu, H., U. Pannicke, K. Schwarz & M. R. Lieber: Length-dependent binding of human XLF to DNA and stimulation of XRCC4.DNA ligase IV activity. J Biol Chem, 282, 11155-62 (2007) (Pubitemid 47100736)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.15 , pp. 11155-11162
    • Lu, H.1    Pannicke, U.2    Schwarz, K.3    Lieber, M.R.4
  • 20
    • 0037155703 scopus 로고    scopus 로고
    • Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination
    • DOI 10.1016/S0092-8674(02)00671-2
    • Ma, Y., U. Pannicke, K. Schwarz & M. R. Lieber: Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V (D)J recombination. Cell, 108, 781-94 (2002) (Pubitemid 34327530)
    • (2002) Cell , vol.108 , Issue.6 , pp. 781-794
    • Ma, Y.1    Pannicke, U.2    Schwarz, K.3    Lieber, M.R.4
  • 23
    • 1542358848 scopus 로고    scopus 로고
    • Repair of oxidative damage in mitochondrial DNA of Saccharomyces cerevisiae: Involvement of the MSH1-dependent pathway
    • DOI 10.1016/j.dnarep.2003.12.005, PII S1568786403003033
    • Dzierzbicki, P., P. Koprowski, M. U. Fikus, E. Malc & Z. Ciesla: Repair of oxidative damage in mitochondrial DNA of Saccharomyces cerevisiae: involvement of the MSH1-dependent pathway. DNA Repair (Amst), 3, 403-11 (2004) (Pubitemid 38316847)
    • (2004) DNA Repair , vol.3 , Issue.4 , pp. 403-411
    • Dzierzbicki, P.1    Koprowski, P.2    Fikus, M.U.3    Malc, E.4    Ciesla, Z.5
  • 24
    • 13944270339 scopus 로고    scopus 로고
    • Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors
    • DOI 10.1016/j.cell.2005.02.003
    • Campisi, J.: Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell, 120, 513-22 (2005) (Pubitemid 40269765)
    • (2005) Cell , vol.120 , Issue.4 , pp. 513-522
    • Campisi, J.1
  • 25
    • 0034798285 scopus 로고    scopus 로고
    • ATM: Genome stability, neuronal development, and cancer cross paths
    • DOI 10.1016/S0065-230X(01)83007-4
    • Shiloh, Y. & M. B. Kastan: ATM: genome stability, neuronal development, and cancer cross paths. Adv Cancer Res, 83, 209-54 (2001) (Pubitemid 32959266)
    • (2001) Advances in Cancer Research , vol.83 , pp. 209-254
    • Shiloh, Y.1    Kastan, M.B.2
  • 28
    • 0029821651 scopus 로고    scopus 로고
    • Dual roles of ATM in the cellular response to radiation and in cell growth control
    • Xu, Y. & D. Baltimore: Dual roles of ATM in the cellular response to radiation and in cell growth control. Genes Dev, 10, 2401-10 (1996) (Pubitemid 26341876)
    • (1996) Genes and Development , vol.10 , Issue.19 , pp. 2401-2410
    • Xu, Y.1    Baltimore, D.2
  • 30
    • 1542500475 scopus 로고    scopus 로고
    • Treatment with a catalytic antioxidant corrects the neurobehavioral defect in ataxia-telangiectasia mice
    • DOI 10.1016/j.freeradbiomed.2004.01.003, PII S0891584904000358
    • Browne, S. E., L. J. Roberts, 2nd, P. A. Dennery, S. R. Doctrow, M. F. Beal, C. Barlow & R. L. Levine: Treatment with a catalytic antioxidant corrects the neurobehavioral defect in ataxia-telangiectasia mice. Free Radic Biol Med, 36, 938-42 (2004) (Pubitemid 38352909)
    • (2004) Free Radical Biology and Medicine , vol.36 , Issue.7 , pp. 938-942
    • Browne, S.E.1    Roberts II, L.J.2    Dennery, P.A.3    Doctrow, S.R.4    Beal, M.F.5    Barlow, C.6    Levine, R.L.7
  • 34
    • 0036012789 scopus 로고    scopus 로고
    • ATM deficiency and oxidative stress: A new dimension of defective response to DNA damage
    • DOI 10.1016/S1568-7864(01)00007-6, PII S1568786401000076
    • Barzilai, A., G. Rotman & Y. Shiloh: ATM deficiency and oxidative stress: a new dimension of defective response o DNA damage. DNA Repair (Amst), 1, 3-25 (2002) (Pubitemid 34475690)
    • (2002) DNA Repair , vol.1 , Issue.1 , pp. 3-25
    • Barzilai, A.1    Rotman, G.2    Shiloh, Y.3
  • 35
    • 0037421896 scopus 로고    scopus 로고
    • Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing
    • DOI 10.1038/nature01385
    • Wong, K. K., R. S. Maser, R. M. Bachoo, J. Menon, D. R. Carrasco, Y. Gu, F. W. Alt & R. A. DePinho: Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature, 421, 643-8 (2003) (Pubitemid 36227673)
    • (2003) Nature , vol.421 , Issue.6923 , pp. 643-648
    • Wong, K.-K.1    Maser, R.S.2    Bachoo, R.M.3    Menon, J.4    Carrasco, D.R.5    Gu, Y.6    Alt, F.W.7    DePinho, R.A.8
  • 36
    • 18344377030 scopus 로고    scopus 로고
    • The p53 pathway: Positive and negative feedback loops
    • DOI 10.1038/sj.onc.1208615
    • Harris, S. L. & A. J. Levine: The p53 pathway: positive and negative feedback loops. Oncogene, 24, 2899-908 (2005) (Pubitemid 40638098)
    • (2005) Oncogene , vol.24 , Issue.17 , pp. 2899-2908
    • Harris, S.L.1    Levine, A.J.2
  • 37
    • 0021835959 scopus 로고
    • Rearrangements of the cellular p53 gene in erythroleukaemic cells transformed by Friend virus
    • DOI 10.1038/314633a0
    • Mowat, M., A. Cheng, N. Kimura, A. Bernstein & S. Benchimol: Rearrangements of the cellular p53 gene in erythroleukaemic cells transformed by Friend virus. Nature, 314, 633-6 (1985) (Pubitemid 15080842)
    • (1985) Nature , vol.314 , Issue.6012 , pp. 633-636
    • Mowat, M.1    Cheng, A.2    Kimura, N.3
  • 38
    • 0023931972 scopus 로고
    • Immortalization of rat embryo fibroblasts by the cellular p53 oncogene
    • Rovinski, B. & S. Benchimol: Immortalization of rat embryo fibroblasts by the cellular p53 oncogene. Oncogene, 2, 445-52 (1988)
    • (1988) Oncogene , vol.2 , pp. 445-452
    • Rovinski, B.1    Benchimol, S.2
  • 43
    • 33750030758 scopus 로고    scopus 로고
    • The regulation of INK4/ARF in cancer and aging
    • DOI 10.1016/j.cell.2006.10.003, PII S0092867406012840
    • Kim, W. Y. & N. E. Sharpless: The regulation of INK4/ARF in cancer and aging. Cell, 127, 265-75 (2006) (Pubitemid 44572384)
    • (2006) Cell , vol.127 , Issue.2 , pp. 265-275
    • Kim, W.Y.1    Sharpless, N.E.2
  • 47
    • 34249888775 scopus 로고    scopus 로고
    • Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
    • DOI 10.1126/science.1142358
    • Saxena, R., B. F. Voight, V. Lyssenko, N. P. Burtt, P. I. de Bakker, H. Chen, J. J. Roix, S. Kathiresan, J. N. Hirschhorn, M. J. Daly, T. E. Hughes, L. Groop, D. Altshuler, P. Almgren, J. C. Florez, J. Meyer, K. Ardlie, K. Bengtsson Bostrom, B. Isomaa, G. Lettre, U. Lindblad, H. N. Lyon, O. Melander, C. Newton-Cheh, P. Nilsson, M. Orho-Melander, L. Rastam, E. K. Speliotes, M. R. Taskinen, T. Tuomi, C. Guiducci, A. Berglund, J. Carlson, L. Gianniny, R. Hackett, L. Hall, J. Holmkvist, E. Laurila, M. Sjogren, M. Sterner, A. Surti, M. Svensson, M. Svensson, R. Tewhey, B. Blumenstiel, M. Parkin, M. Defelice, R. Barry, W. Brodeur, J. Camarata, N. Chia, M. Fava, J. Gibbons, B. Handsaker, C. Healy, K. Nguyen, C. Gates, C. Sougnez, D. Gage, M. Nizzari, S. B. Gabriel, G. W. Chirn, Q. Ma, H. Parikh, D. Richardson, D. Ricke & S. Purcell: Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science, 316, 1331-6 (2007) (Pubitemid 46871653)
    • (2007) Science , vol.316 , Issue.5829 , pp. 1331-1336
    • Saxena, R.1    Voight, B.F.2    Lyssenko, V.3    Burtt, N.P.4    De Bakker, P.I.W.5    Chen, H.6    Roix, J.J.7    Kathiresan, S.8    Hirschhorn, J.N.9    Daly, M.J.10    Hughes, T.E.11    Groop, L.12    Altshuler, D.13
  • 48
    • 34548153747 scopus 로고    scopus 로고
    • How stem cells age and why this makes us grow old
    • DOI 10.1038/nrm2241, PII NRM2241
    • Sharpless, N. E. & R. A. DePinho: How stem cells age and why this makes us grow old. Nat Rev Mol Cell Biol, 8,703-13 (2007) (Pubitemid 47312828)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.9 , pp. 703-713
    • Sharpless, N.E.1    DePinho, R.A.2
  • 49
    • 0141757494 scopus 로고    scopus 로고
    • Regulation and mechanisms of mammalian double-strand break repair
    • Valerie, K. & L. F. Povirk: Regulation and mechanisms of mammalian double-strand break repair. Oncogene, 22, 5792-812 (2003)
    • (2003) Oncogene , vol.22 , pp. 5792-4812
    • Valerie, K.1    Povirk, L.F.2
  • 50
    • 13944281226 scopus 로고    scopus 로고
    • Molecular functions of BRCA1 in the DNA damage response
    • Scully, R., A. Xie & G. Nagaraju: Molecular Functions of BRCA1 in the DNA Damage Response. Cancer Biol Ther, 3, 521-7 (2004) (Pubitemid 41351121)
    • (2004) Cancer Biology and Therapy , vol.3 , Issue.6 , pp. 521-527
    • Scully, R.1    Xie, A.2    Nagaraju, G.3
  • 51
    • 0037439071 scopus 로고    scopus 로고
    • Senescence, aging, and malignant transformation mediated by p53 in mice lacking the brca1 full-length isoform
    • DOI 10.1101/gad.1050003
    • Cao, L., W. Li, S. Kim, S. G. Brodie & C. X. Deng: Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform. Genes Dev, 17, 201-13 (2003) (Pubitemid 36105893)
    • (2003) Genes and Development , vol.17 , Issue.2 , pp. 201-213
    • Cao, L.1    Li, W.2    Kim, S.3    Brodie, S.G.4    Deng, C.-X.5
  • 54
    • 0034690249 scopus 로고    scopus 로고
    • Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development
    • DOI 10.1038/35009138
    • Gao, Y., D. O. Ferguson, W. Xie, J. P. Manis, J. Sekiguchi, K. M. Frank, J. Chaudhuri, J. Horner, R. A. DePinho & F. W. Alt: Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development. Nature, 404, 897-900 (2000) (Pubitemid 30230344)
    • (2000) Nature , vol.404 , Issue.6780 , pp. 897-900
    • Gao, Y.1    Ferguson, D.O.2    Xie, W.3    Manis, J.P.4    Sekiguchi, J.5    Frank, K.M.6    Chaudhuri, J.7    Horner, J.8    DePinho, R.A.9    Alt, F.W.10
  • 55
    • 33745752959 scopus 로고    scopus 로고
    • Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression
    • DOI 10.1038/sj.emboj.7601167, PII 7601167
    • Chao, C., D. Herr, J. Chun & Y. Xu: Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression. Embo J, 25, 2615-22 (2006) (Pubitemid 44012243)
    • (2006) EMBO Journal , vol.25 , Issue.11 , pp. 2615-2622
    • Chao, C.1    Herr, D.2    Chun, J.3    Xu, Y.4
  • 57
    • 0034732239 scopus 로고    scopus 로고
    • Dna repair protein Ku80 suppresses chromosomal aberrations and malignant transformation
    • DOI 10.1038/35006670
    • Difilippantonio, M. J., J. Zhu, H. T. Chen, E. Meffre, M. C. Nussenzweig, E. E. Max, T. Ried & A. Nussenzweig: DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation. Nature, 404, 510-4 (2000) (Pubitemid 30186895)
    • (2000) Nature , vol.404 , Issue.6777 , pp. 510-514
    • Difilippantonio, M.J.1    Zhu, J.2    Chen, H.T.3    Meffre, E.4    Nussenzweig, M.C.5    Max, E.E.6    Ried, T.7    Nussenzweig, A.8
  • 60
    • 36849088515 scopus 로고    scopus 로고
    • Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancer
    • DOI 10.1128/MCB.00785-07
    • Li, H., H. Vogel, V. B. Holcomb, Y. Gu & P. Hasty: Deletion of Either Ku70, Ku80 or Both Causes Early Aging Without Substantially Increased Cancer. Mol Cell Biol, 23, 8205-8214 (2007) (Pubitemid 350234234)
    • (2007) Molecular and Cellular Biology , vol.27 , Issue.23 , pp. 8205-8214
    • Li, H.1    Vogel, H.2    Holcomb, V.B.3    Gu, Y.4    Hasty, P.5
  • 61
    • 2942547771 scopus 로고    scopus 로고
    • Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice
    • DOI 10.1038/sj.embor.7400127
    • Espejel, S., M. Martin, P. Klatt, J. Martin-Caballero, J. M. Flores & M. A. Blasco: Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice. EMBO Rep, 5, 503-9 (2004) (Pubitemid 38745042)
    • (2004) EMBO Reports , vol.5 , Issue.5 , pp. 503-509
    • Espejel, S.1    Martin, M.2    Klatt, P.3    Martin-Caballero, J.4    Flores, J.5    Blasco, M.A.6
  • 63
    • 0037470542 scopus 로고    scopus 로고
    • Aging and genome maintenance: Lessons from the mouse?
    • DOI 10.1126/science.1079161
    • Hasty, P., J. Campisi, J. Hoeijmakers, H. van Steeg & J. Vijg: Aging and genome maintenance: lessons from the mouse? Science, 299, 1355-9 (2003) (Pubitemid 36254641)
    • (2003) Science , vol.299 , Issue.5611 , pp. 1355-1359
    • Hasty, P.1    Campisi, J.2    Hoeijmakers, J.3    Van Steeg, H.4    Vijg, J.5
  • 64
    • 33847007529 scopus 로고    scopus 로고
    • The mechanics of base excision repair, and its relationship to aging and disease
    • DOI 10.1016/j.dnarep.2006.10.017, PII S1568786406003260, Repair of small base lesions in DNA-from molecular biology to phenotype
    • Wilson, D. M., 3rd & V. A. Bohr: The mechanics of base excision repair, and its relationship to aging and disease. DNA Repair (Amst), 6, 544-59 (2007) (Pubitemid 46357056)
    • (2007) DNA Repair , vol.6 , Issue.4 , pp. 544-559
    • Wilson III, D.M.1    Bohr, V.A.2
  • 65
    • 27744531188 scopus 로고    scopus 로고
    • Genetic polymorphisms in the base excision repair pathway and cancer risk: A huge review
    • DOI 10.1093/aje/kwi318
    • Hung, R. J., J. Hall, P. Brennan & P. Boffetta: Genetic polymorphisms in the base excision repair pathway and ancer risk: a HuGE review. Am J Epidemiol, 162, 925-42 (2005) (Pubitemid 41619464)
    • (2005) American Journal of Epidemiology , vol.162 , Issue.10 , pp. 925-942
    • Hung, R.J.1    Hall, J.2    Brennan, P.3    Boffetta, P.4
  • 67
    • 16244375578 scopus 로고    scopus 로고
    • The overexpression of specialized DNA polymerases in cancer
    • DOI 10.1016/j.dnarep.2005.01.005
    • Albertella, M. R., A. Lau & M. J. O'Connor: The overexpression of specialized DNA polymerases in cancer. DNA Repair (Amst), 4, 583-93 (2005) (Pubitemid 40462046)
    • (2005) DNA Repair , vol.4 , Issue.5 , pp. 583-593
    • Albertella, M.R.1    Lau, A.2    O'Connor, M.J.3
  • 69
    • 0035266131 scopus 로고    scopus 로고
    • Altered expression of Ape1/ref-1 in germ cell tumors and overexpression in NT2 cells confers resistance to bleomycin and radiation
    • Robertson, K. A., H. A. Bullock, Y. Xu, R. Tritt, E. Zimmerman, T. M. Ulbright, R. S. Foster, L. H. Einhorn & M. R. Kelley: Altered expression of Ape1/ref-1 in germ cell tumors and overexpression in NT2 cells confers resistance to bleomycin and radiation. Cancer Res, 61, 2220-5 (2001) (Pubitemid 32692051)
    • (2001) Cancer Research , vol.61 , Issue.5 , pp. 2220-2225
    • Robertson, K.A.1    Bullock, H.A.2    Xu, Y.3    Tritt, R.4    Zimmerman, E.5    Ulbright, T.M.6    Foster, R.S.7    Einhorn, L.H.8    Kelley, M.R.9
  • 70
    • 33845683300 scopus 로고    scopus 로고
    • Nucleotide excision repair disorders and the balance between cancer and aging
    • Andressoo, J. O., J. H. Hoeijmakers & J. R. Mitchell: Nucleotide excision repair disorders and the balance between cancer and aging. Cell Cycle, 5, 2886-8 (2006) (Pubitemid 44953941)
    • (2006) Cell Cycle , vol.5 , Issue.24 , pp. 2886-2888
    • Andressoo, J.-O.1    Hoeijmakers, J.H.J.2    Mitchell, J.R.3
  • 71
    • 0035340869 scopus 로고    scopus 로고
    • Trichothiodystrophy, a transcription syndrome
    • DOI 10.1016/S0168-9525(01)02280-6, PII S0168952501022806
    • Bergmann, E. & J. M. Egly: Trichothiodystrophy, a transcription syndrome. Trends Genet, 17, 279-86 (2001) (Pubitemid 32378751)
    • (2001) Trends in Genetics , vol.17 , Issue.5 , pp. 279-286
    • Bergmann, E.1    Egly, J.-M.2
  • 73
    • 1542309071 scopus 로고    scopus 로고
    • Growth retardation, early death, and dna repair defects in mice deficient for the nucleotide excision repair enzyme XPF
    • DOI 10.1128/MCB.24.3.1200-1205.2004
    • Tian, M., R. Shinkura, N. Shinkura & F. W. Alt: Growth retardation, early death, and DNA repair defects in mice deficient for the nucleotide excision repair enzyme XPF. Mol Cell Biol, 24, 1200-5 (2004) (Pubitemid 38112182)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.3 , pp. 1200-1205
    • Tian, M.1    Shinkura, R.2    Shinkura, N.3    Alt, F.W.4
  • 75
    • 0027378895 scopus 로고
    • Mice with DNA repair gene (ERCC-1) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning
    • DOI 10.1038/ng1193-217
    • McWhir, J., J. Selfridge, D. J. Harrison, S. Squires & D. W. Melton: Mice with DNA repair gene (ERCC-1) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning. Nat Genet, 5, 217-24 (1993) (Pubitemid 23330382)
    • (1993) Nature Genetics , vol.5 , Issue.3 , pp. 217-224
    • McWhir, J.1    Selfridge, J.2    Harrison, D.J.3    Squires, S.4    Melton, D.W.5
  • 79
    • 0034054019 scopus 로고    scopus 로고
    • Nucleotide excision repair and human syndromes
    • de Boer, J. & J. H. Hoeijmakers: Nucleotide excision repair and human syndromes. Carcinogenesis, 21, 453-60 (2000) (Pubitemid 30137930)
    • (2000) Carcinogenesis , vol.21 , Issue.3 , pp. 453-460
    • De Boer, J.1    Hoeijmakers, J.H.J.2
  • 80
    • 13944278132 scopus 로고    scopus 로고
    • Mitochondria, oxidants, and aging
    • DOI 10.1016/j.cell.2005.02.001
    • Balaban, R. S., S. Nemoto & T. Finkel: Mitochondria, oxidants, and aging. Cell, 120, 483-95 (2005) (Pubitemid 40269763)
    • (2005) Cell , vol.120 , Issue.4 , pp. 483-495
    • Balaban, R.S.1    Nemoto, S.2    Finkel, T.3
  • 84
    • 34447528668 scopus 로고    scopus 로고
    • Type 5 adenylyl cyclase disruption increases longevity and protects against stress
    • DOI 10.1016/j.cell.2007.05.038, PII S0092867407006770
    • Yan, L., D. E. Vatner, P. O'Connor J, A. Ivessa, H. Ge, W. Chen, S. Hirotani, Y. Ishikawa, J. Sadoshima & S. F. Vatner: Type 5 adenylyl cyclase disruption increases longevity and protects against stress. Cell, 130, 247-58 (2007) (Pubitemid 47081133)
    • (2007) Cell , vol.130 , Issue.2 , pp. 247-258
    • Yan, L.1    Vatner, D.E.2    O'Connor, J.P.3    Ivessa, A.4    Ge, H.5    Chen, W.6    Hirotani, S.7    Ishikawa, Y.8    Sadoshima, J.9    Vatner, S.F.10
  • 88
    • 13944280713 scopus 로고    scopus 로고
    • Genetic modulation of senescent phenotypes in Homo sapiens
    • DOI 10.1016/j.cell.2005.01.031
    • Martin, G. M.: Genetic modulation of senescent phenotypes in Homo sapiens. Cell, 120, 523-32 (2005) (Pubitemid 40269766)
    • (2005) Cell , vol.120 , Issue.4 , pp. 523-532
    • Martin, G.M.1
  • 89
    • 34247390746 scopus 로고    scopus 로고
    • Werner and Hutchinson-Gilford progeria syndromes: Mechanistic basis of human progeroid diseases
    • DOI 10.1038/nrm2161, PII NRM2161
    • Kudlow, B. A., B. K. Kennedy & R. J. Monnat, Jr.: Werner and Hutchinson-Gilford progeria syndromes: mechanistic basis of human progeroid diseases. Nat Rev Mol Cell Biol, 8, 394-404 (2007) (Pubitemid 46643238)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.5 , pp. 394-404
    • Kudlow, B.A.1    Kennedy, B.K.2    Monnat Jr., R.J.3
  • 93
    • 34548667973 scopus 로고    scopus 로고
    • Telomere length, stem cells and aging
    • DOI 10.1038/nchembio.2007.38, PII NCHEMBIO200738
    • Blasco, M. A.: Telomere length, stem cells and aging. Nat Chem Biol, 3, 640-9 (2007) (Pubitemid 47417712)
    • (2007) Nature Chemical Biology , vol.3 , Issue.10 , pp. 640-649
    • Blasco, M.A.1
  • 96
    • 33746883839 scopus 로고    scopus 로고
    • Expression of disease-causing lamin A mutants impairs the formation of DNA repair foci
    • DOI 10.1242/jcs.03009
    • Manju, K., B. Muralikrishna & V. K. Parnaik: Expression of disease-causing lamin A mutants impairs the formation of DNA repair foci. J Cell Sci, 119, 2704-14 (2006) (Pubitemid 44184007)
    • (2006) Journal of Cell Science , vol.119 , Issue.13 , pp. 2704-2714
    • Manju, K.1    Muralikrishna, B.2    Parnaik, V.K.3
  • 98
    • 33747883762 scopus 로고    scopus 로고
    • Dedicated to the core: Understanding the Fanconi anemia complex
    • DOI 10.1016/j.dnarep.2006.05.009, PII S1568786406001492, Mechanisms of Chromosomal Translocations
    • Gurtan, A. M. & A. D. D'Andrea: Dedicated to the core: understanding the Fanconi anemia complex. DNARepair (Amst), 5, 1119-25 (2006) (Pubitemid 44291606)
    • (2006) DNA Repair , vol.5 , Issue.9-10 , pp. 1119-1125
    • Gurtan, A.M.1    D'Andrea, A.D.2
  • 99
    • 29244489543 scopus 로고    scopus 로고
    • Fanconi anemia (cross)linked to DNA repair
    • DOI 10.1016/j.cell.2005.12.009, PII S0092867405013917
    • Niedernhofer, L. J., A. S. Lalai & J. H. Hoeijmakers: Fanconi anemia (cross)linked to DNA repair. Cell, 123, 1191-8 (2005) (Pubitemid 41821778)
    • (2005) Cell , vol.123 , Issue.7 , pp. 1191-1198
    • Niedernhofer, L.J.1    Lalai, A.S.2    Hoeijmakers, J.H.J.3
  • 100
    • 0035856949 scopus 로고    scopus 로고
    • Insulin signalling and the regulation of glucose and lipid metabolism
    • DOI 10.1038/414799a
    • Saltiel, A. R. & C. R. Kahn: Insulin signalling and the regulation of glucose and lipid metabolism. Nature, 414,799-806 (2001) (Pubitemid 34000783)
    • (2001) Nature , vol.414 , Issue.6865 , pp. 799-806
    • Saltiel, A.R.1    Kahn, C.R.2
  • 101
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley, L. C.: The phosphoinositide 3-kinase pathway. Science, 296, 1655-7 (2002)
    • (2002) Science , vol.296 , pp. 1655-1667
    • Cantley, L.C.1
  • 102
    • 27844497945 scopus 로고    scopus 로고
    • FOXO transcription factors at the interface between longevity and tumor suppression
    • DOI 10.1038/sj.onc.1209086, PII 1209086
    • Greer, E. L. & A. Brunet: FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene, 24, 7410-25 (2005) (Pubitemid 41637981)
    • (2005) Oncogene , vol.24 , Issue.50 , pp. 7410-7425
    • Greer, E.L.1    Brunet, A.2
  • 104
    • 0035853552 scopus 로고    scopus 로고
    • Regulation of longevity and stress resistance by Sch9 in yeast
    • DOI 10.1126/science.1059497
    • Fabrizio, P., F. Pozza, S. D. Pletcher, C. M. Gendron & V. D. Longo: Regulation of longevity and stress resistance by Sch9 in yeast. Science, 292, 288-90 (2001) (Pubitemid 32295387)
    • (2001) Science , vol.292 , Issue.5515 , pp. 288-290
    • Fabrizio, P.1    Pozza, F.2    Pletcher, S.D.3    Gendron, C.M.4    Longo, V.D.5
  • 106
    • 0034626747 scopus 로고    scopus 로고
    • Genetic pathways that regulate ageing in model organisms
    • Guarente, L. & C. Kenyon: Genetic pathways that regulate ageing in model organisms. Nature, 408, 255-62. (2000)
    • (2000) Nature , vol.408 , pp. 255-262
    • Guarente, L.1    Kenyon, C.2
  • 107
    • 33747588775 scopus 로고    scopus 로고
    • Mutations that increase the life span of C. Elegans inhibit tumor growth
    • Pinkston, J. M., D. Garigan, M. Hansen & C. Kenyon: Mutations that increase the life span of C. elegans inhibit tumor growth. Science, 313, 971-5 (2006)
    • (2006) Science , vol.313 , pp. 971-975
    • Pinkston, J.M.1    Garigan, D.2    Hansen, M.3    Kenyon, C.4
  • 108
    • 35648973774 scopus 로고    scopus 로고
    • DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans
    • DOI 10.1038/ng.2007.1, PII NG20071
    • Pinkston-Gosse, J. & C. Kenyon: DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans. Nat Genet, 39, 1403-9 (2007) (Pubitemid 350034993)
    • (2007) Nature Genetics , vol.39 , Issue.11 , pp. 1403-1409
    • Pinkston-Gosse, J.1    Kenyon, C.2
  • 109
    • 0035815445 scopus 로고    scopus 로고
    • A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function
    • DOI 10.1126/science.1057987
    • Tatar, M., A. Kopelman, D. Epstein, M. P. Tu, C. M. Yin & R. S. Garofalo: A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science, 292, 107-10 (2001) (Pubitemid 32289137)
    • (2001) Science , vol.292 , Issue.5514 , pp. 107-110
    • Tatar, M.1    Kopelman, A.2    Epstein, D.3    Tu, M.-P.4    Yin, C.-M.5    Garofalo, R.S.6
  • 110
    • 0035815414 scopus 로고    scopus 로고
    • Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein
    • DOI 10.1126/science.1057991
    • Clancy, D. J., D. Gems, L. G. Harshman, S. Oldham, H. Stocker, E. Hafen, S. J. Leevers & L. Partridge: Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science, 292, 104-6 (2001) (Pubitemid 32289136)
    • (2001) Science , vol.292 , Issue.5514 , pp. 104-106
    • Clancy, D.J.1    Gems, D.2    Harshman, L.G.3    Oldham, S.4    Stocker, H.5    Hafen, E.6    Leevers, S.J.7    Partridge, L.8
  • 111
    • 2942563805 scopus 로고    scopus 로고
    • Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body
    • DOI 10.1038/nature02549
    • Hwangbo, D. S., B. Gershman, M. P. Tu, M. Palmer & M. Tatar: Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature, 429, 562-6 (2004) (Pubitemid 38737660)
    • (2004) Nature , vol.429 , Issue.6991 , pp. 562-566
    • Hwangbo, D.S.1    Garsham, B.2    Tu, M.-P.3    Palmer, M.4    Tatar, M.5
  • 112
    • 9644278037 scopus 로고    scopus 로고
    • Insulin regulation of heart function in aging fruit flies
    • DOI 10.1038/ng1476
    • Wessells, R. J., E. Fitzgerald, J. R. Cypser, M. Tatar & R. Bodmer: Insulin regulation of heart function in agingfruit flies. Nat Genet, 36, 1275-81 (2004) (Pubitemid 39577935)
    • (2004) Nature Genetics , vol.36 , Issue.12 , pp. 1275-1281
    • Wessells, R.J.1    Fitzgerald, E.2    Cypser, J.R.3    Tatar, M.4    Bodmer, R.5
  • 113
    • 3042648746 scopus 로고    scopus 로고
    • Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
    • DOI 10.1016/j.cub.2004.03.059, PII S0960982204002386
    • Kapahi, P., B. M. Zid, T. Harper, D. Koslover, V. Sapin & S. Benzer: Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol, 14, 885-90 (2004) (Pubitemid 38800910)
    • (2004) Current Biology , vol.14 , Issue.10 , pp. 885-890
    • Kapahi, P.1    Zid, B.M.2    Harper, T.3    Koslover, D.4    Sapin, V.5    Benzer, S.6
  • 114
    • 27544500981 scopus 로고    scopus 로고
    • Growing roles for the mTOR pathway
    • DOI 10.1016/j.ceb.2005.09.009, PII S0955067405001481
    • Sarbassov, D. D., S. M. Ali & D. M. Sabatini: Growing roles for the mTOR pathway. Curr Opin Cell Biol, 17, 596-603 (2005) (Pubitemid 41540408)
    • (2005) Current Opinion in Cell Biology , vol.17 , Issue.6 , pp. 596-603
    • Sarbassov, D.D.1    Ali, S.M.2    Sabatini, D.M.3
  • 116
    • 27544434895 scopus 로고    scopus 로고
    • The insulin/IGF-1 signaling in mammals and its relevance to human longevity
    • DOI 10.1016/j.exger.2005.06.014, PII S0531556505001609, Metabolism, Aging and Longevity
    • Rincon, M., E. Rudin & N. Barzilai: The insulin/IGF-1 signaling in mammals and its relevance to human longevity. Exp Gerontol, 40, 873-7 (2005) (Pubitemid 41540436)
    • (2005) Experimental Gerontology , vol.40 , Issue.11 , pp. 873-877
    • Rincon, M.1    Rudin, E.2    Barzilai, N.3
  • 117
    • 34547097247 scopus 로고    scopus 로고
    • Brain IRS2 signaling coordinates life span and nutrient homeostasis
    • DOI 10.1126/science.1142179
    • Taguchi, A., L. M. Wartschow & M. F. White: Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science, 317, 369-72 (2007) (Pubitemid 47106376)
    • (2007) Science , vol.317 , Issue.5836 , pp. 369-372
    • Taguchi, A.1    Wartschow, L.M.2    White, M.F.3
  • 118
    • 0037942739 scopus 로고    scopus 로고
    • Extended longevity in mice lacking the insulin receptor in adipose tissue
    • DOI 10.1126/science.1078223
    • Bluher, M., B. B. Kahn & C. R. Kahn: Extended longevity in mice lacking the insulin receptor in adipose tissue. Science, 299, 572-4 (2003) (Pubitemid 36135156)
    • (2003) Science , vol.299 , Issue.5606 , pp. 572-574
    • Bluher, M.1    Kahn, B.B.2    Kahn, C.R.3
  • 119
    • 33644513730 scopus 로고    scopus 로고
    • Beyond PTEN mutations: The PI3K pathway as an integrator of multiple inputs during tumorigenesis
    • DOI 10.1038/nrc1819, PII N1819
    • Cully, M., H. You, A. J. Levine & T. W. Mak: Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer, 6, 184-92 (2006) (Pubitemid 43292562)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.3 , pp. 184-192
    • Cully, M.1    You, H.2    Levine, A.J.3    Mak, T.W.4
  • 120
    • 0034681264 scopus 로고    scopus 로고
    • The multiple roles of PTEN in tumor suppression
    • Di Cristofano, A. & P. P. Pandolfi: The multiple roles of PTEN in tumor suppression. Cell, 100, 387-90 (2000)
    • (2000) Cell , vol.100 , pp. 387-390
    • Di Cristofano, A.1    Pandolfi, P.P.2
  • 121
    • 0042316755 scopus 로고    scopus 로고
    • PTEN: One gene, Many syndromes
    • DOI 10.1002/humu.10257
    • Eng, C.: PTEN: one gene, many syndromes. Hum Mutat, 22, 183-98 (2003) (Pubitemid 37071635)
    • (2003) Human Mutation , vol.22 , Issue.3 , pp. 183-198
    • Eng, C.1
  • 122
    • 0035113511 scopus 로고    scopus 로고
    • Identification of a PTEN mutation in a family with cowden syndrome and Bannayan-Zonana syndrome
    • DOI 10.1067/mjd.2001.110390
    • Wanner, M., J. T. Celebi & M. Peacocke: Identification of a PTEN mutation in a family with Cowden syndrome and Bannayan-Zonana syndrome. J Am Acad Dermatol, 44, 183-7 (2001) (Pubitemid 32172177)
    • (2001) Journal of the American Academy of Dermatology , vol.44 , Issue.2 , pp. 183-187
    • Wanner, M.1    Celebi, J.T.2    Peacocke, M.3
  • 123
    • 0031870959 scopus 로고    scopus 로고
    • Pten is essential for embryonic development and tumour suppression
    • DOI 10.1038/1235
    • Di Cristofano, A., B. Pesce, C. Cordon-Cardo & P. P. Pandolfi: Pten is essential for embryonic development and tumour suppression. Nat Genet, 19, 348-55 (1998) (Pubitemid 28357906)
    • (1998) Nature Genetics , vol.19 , Issue.4 , pp. 348-355
    • Di Cristofano, A.1    Pesce, B.2    Cordon-Cardo, C.3    Pandolfi, P.P.4
  • 131
    • 25444480531 scopus 로고    scopus 로고
    • PTEN loss inhibits CHK1 to cause double stranded-DNA breaks in cells
    • Puc, J. & R. Parsons: PTEN loss inhibits CHK1 to cause double stranded-DNA breaks in cells. Cell Cycle, 4, 927-9 (2005) (Pubitemid 41359759)
    • (2005) Cell Cycle , vol.4 , Issue.7 , pp. 927-929
    • Puc, J.1    Parsons, R.2
  • 132
    • 33845999615 scopus 로고    scopus 로고
    • Essential role for nuclear pten in maintaining chromosomal integrity
    • DOI 10.1016/j.cell.2006.11.042, PII S0092867406015534
    • Shen, W. H., A. S. Balajee, J. Wang, H. Wu, C. Eng, P. P. Pandolfi & Y. Yin: Essential role for nuclear PTEN inmaintaining chromosomal integrity. Cell, 128, 157-70 (2007) (Pubitemid 46048887)
    • (2007) Cell , vol.128 , Issue.1 , pp. 157-170
    • Shen, W.H.1    Balajee, A.S.2    Wang, J.3    Wu, H.4    Eng, C.5    Pandolfi, P.P.6    Yin, Y.7
  • 133
    • 33747819801 scopus 로고    scopus 로고
    • MTOR and cancer: Insights into a complex relationship
    • DOI 10.1038/nrc1974, PII NRC1974
    • Sabatini, D. M.: mTOR and cancer: insights into a complex relationship. Nat Rev Cancer, 6, 729-34 (2006) (Pubitemid 44286004)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.9 , pp. 729-734
    • Sabatini, D.M.1
  • 135
    • 0037134040 scopus 로고    scopus 로고
    • DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein
    • DOI 10.1126/science.1068712
    • Tran, H., A. Brunet, J. M. Grenier, S. R. Datta, A. J. Fornace, Jr., P. S. DiStefano, L. W. Chiang & M. E.Greenberg: DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science, 296, 530-4 (2002) (Pubitemid 34408672)
    • (2002) Science , vol.296 , Issue.5567 , pp. 530-534
    • Tran, H.1    Brunet, A.2    Grenier, J.M.3    Datta, S.R.4    Fornace Jr., A.J.5    DiStefano, P.S.6    Chiang, L.W.7    Greenberg, M.E.8
  • 136
    • 34147208714 scopus 로고    scopus 로고
    • Downregulation of catalase by reactive oxygen species via PI 3 kinase/Akt signaling in mesangial cells
    • DOI 10.1002/jcp.20953
    • Venkatesan, B., L. Mahimainathan, F. Das, N. Ghosh-Choudhury & G. Ghosh Choudhury: Downregulation of catalase by reactive oxygen species via PI 3 kinase/Akt signaling in mesangial cells. J Cell Physiol, 211, 457-67 (2007) (Pubitemid 46580099)
    • (2007) Journal of Cellular Physiology , vol.211 , Issue.2 , pp. 457-467
    • Venkatesan, B.1    Mahimainathan, L.2    Das, F.3    Ghosh-Choudhury, N.4    Choudhury, G.G.5
  • 138
    • 27844445642 scopus 로고    scopus 로고
    • Perturbations of the AKT signaling pathway in human cancer
    • DOI 10.1038/sj.onc.1209085, PII 1209085
    • Altomare, D. A. & J. R. Testa: Perturbations of the AKT signaling pathway in human cancer. Oncogene, 24, 7455-64 (2005) (Pubitemid 41637985)
    • (2005) Oncogene , vol.24 , Issue.50 , pp. 7455-7464
    • Altomare, D.A.1    Testa, J.R.2
  • 139
    • 27844598284 scopus 로고    scopus 로고
    • The Akt/PKB pathway: Molecular target for cancer drug discovery
    • DOI 10.1038/sj.onc.1209088, PII 1209088
    • Cheng, J. Q., C. W. Lindsley, G. Z. Cheng, H. Yang & S. V. Nicosia: The Akt/PKB pathway: molecular target for cancer drug discovery. Oncogene, 24, 7482-92 (2005) (Pubitemid 41637988)
    • (2005) Oncogene , vol.24 , Issue.50 , pp. 7482-7492
    • Cheng, J.Q.1    Lindsley, C.W.2    Cheng, G.Z.3    Yang, H.4    Nicosia, S.V.5
  • 140
    • 33749430399 scopus 로고    scopus 로고
    • Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner
    • DOI 10.1016/j.ccr.2006.08.022, PII S1535610806002789
    • Skeen, J. E., P. T. Bhaskar, C. C. Chen, W. S. Chen, X. D. Peng, V. Nogueira, A. Hahn-Windgassen, H. Kiyokawa & N. Hay: Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner. Cancer Cell, 10, 269-80 (2006) (Pubitemid 44512190)
    • (2006) Cancer Cell , vol.10 , Issue.4 , pp. 269-280
    • Skeen, J.E.1    Bhaskar, P.T.2    Chen, C.-C.3    Chen, W.S.4    Peng, X.-d.5    Nogueira, V.6
  • 141
    • 33750906556 scopus 로고    scopus 로고
    • The redox regulation of PI 3-kinasedependent signaling
    • Leslie, N. R.: The redox regulation of PI 3-kinasedependent signaling. Antioxid Redox Signal, 8, 1765-74 (2006)
    • (2006) Antioxid Redox Signal , vol.8 , pp. 1765-1774
    • Leslie, N.R.1
  • 143
    • 0019364691 scopus 로고
    • Regulation of transcription in expressed and unexpressed mating type cassettes of yeast
    • DOI 10.1038/289239a0
    • Klar, A. J., J. N. Strathern, J. R. Broach & J. B. Hicks: Regulation of transcription in expressed and unexpressed mating type cassettes of yeast. Nature, 289, 239-44 (1981) (Pubitemid 11180670)
    • (1981) Nature , vol.289 , Issue.5795 , pp. 239-244
    • Klar, A.J.S.1    Strathern, J.N.2    Broach, J.R.3    Hicks, J.B.4
  • 144
    • 0023340731 scopus 로고
    • Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae
    • Rine, J. & I. Herskowitz: Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae. Genetics, 116, 9-22. (1987)
    • (1987) Genetics , vol.116 , pp. 9-22
    • Rine, J.1    Herskowitz, I.2
  • 145
    • 3943054839 scopus 로고    scopus 로고
    • The Sir2 family of protein deacetylases
    • DOI 10.1146/annurev.biochem.73.011303.073651
    • Blander, G. & L. Guarente: The sir2 family of protein deacetylases. Annu Rev Biochem, 73, 417-35 (2004) (Pubitemid 39050375)
    • (2004) Annual Review of Biochemistry , vol.73 , pp. 417-435
    • Blander, G.1    Guarente, L.2
  • 146
    • 0033887456 scopus 로고    scopus 로고
    • Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins
    • DOI 10.1006/bbrc.2000.3000
    • Frye, R. A.: Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem Biophys Res Commun, 273, 793-8. (2000) (Pubitemid 30599063)
    • (2000) Biochemical and Biophysical Research Communications , vol.273 , Issue.2 , pp. 793-798
    • Frye, R.A.1
  • 149
    • 33751113602 scopus 로고    scopus 로고
    • Mammalian sirtuins - Emerging roles in physiology, aging, and calorie restriction
    • DOI 10.1101/gad.1467506
    • Haigis, M. C. & L. P. Guarente: Mammalian sirtuins-emerging roles in physiology, aging, and calorie restriction.Genes Dev, 20, 2913-21 (2006) (Pubitemid 44771725)
    • (2006) Genes and Development , vol.20 , Issue.21 , pp. 2913-2921
    • Haigis, M.C.1    Guarente, L.P.2
  • 151
    • 0031459980 scopus 로고    scopus 로고
    • Extrachromosomal rDNA circles - A cause of aging in yeast
    • DOI 10.1016/S0092-8674(00)80493-6
    • Sinclair, D. A. & L. Guarente: Extrachromosomal rDNA circles-a cause of aging in yeast. Cell, 91, 1033-42. (1997) (Pubitemid 28027835)
    • (1997) Cell , vol.91 , Issue.7 , pp. 1033-1042
    • Sinclair, D.A.1    Guarente, L.2
  • 152
    • 0033214237 scopus 로고    scopus 로고
    • The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
    • DOI 10.1101/gad.13.19.2570
    • Kaeberlein, M., M. McVey & L. Guarente: The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev, 13, 2570-80. (1999) (Pubitemid 29489648)
    • (1999) Genes and Development , vol.13 , Issue.19 , pp. 2570-2580
    • Kaeberlein, M.1    McVey, M.2    Guarente, L.3
  • 154
    • 0030964526 scopus 로고    scopus 로고
    • Silencing factors participate in DNA repair and rscombination in Saccharomyces cersvisiae
    • DOI 10.1038/42288
    • Tsukamoto, Y., J. Kato & H. Ikeda: Silencing factors participate in DNA repair and recombination in Saccharomyces cerevisiae. Nature, 388, 900-3. (1997) (Pubitemid 27377065)
    • (1997) Nature , vol.388 , Issue.6645 , pp. 900-903
    • Tsukamoto, Y.1    Kato, J.-I.2    Ikeda, H.3
  • 155
    • 0033612287 scopus 로고    scopus 로고
    • Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast
    • DOI 10.1016/S0092-8674(00)80773-4
    • Martin, S. G., T. Laroche, N. Suka, M. Grunstein & S. M. Gasser: Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast. Cell, 97, 621-33 (1999) (Pubitemid 29256965)
    • (1999) Cell , vol.97 , Issue.5 , pp. 621-633
    • Martin, S.G.1    Laroche, T.2    Suka, N.3    Grunstein, M.4    Gasser, S.M.5
  • 156
    • 0033612189 scopus 로고    scopus 로고
    • MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks
    • DOI 10.1016/S0092-8674(00)80772-2
    • Mills, K. D., D. A. Sinclair & L. Guarente: MEC1-dependent redistribution of the Sir3 silencing protein fromtelomeres to DNA double-strand breaks. Cell, 97, 609-20. (1999) (Pubitemid 29256964)
    • (1999) Cell , vol.97 , Issue.5 , pp. 609-620
    • Mills, K.D.1    Sinclair, D.A.2    Guarente, L.3
  • 157
    • 0033539095 scopus 로고    scopus 로고
    • DNA damage triggers disruption of telomeric silencing and Mec1p-dependent relocation of Sir3p
    • DOI 10.1016/S0960-9822(99)80424-2
    • McAinsh, A. D., S. Scott-Drew, J. A. Murray & S. P. Jackson: DNA damage triggers disruption of telomeric silencing and Mec1p-dependent relocation of Sir3p. Curr Biol, 9, 963-6. (1999) (Pubitemid 29442481)
    • (1999) Current Biology , vol.9 , Issue.17 , pp. 963-966
    • McAinsh, A.D.1    Scott-Drew, S.2    Murray, J.A.H.3    Jackson, S.P.4
  • 158
    • 0033611465 scopus 로고    scopus 로고
    • Yeast celltype regulation of DNA repair
    • Astrom, S. U., S. M. Okamura & J. Rine: Yeast celltype regulation of DNA repair. Nature, 397, 310-(1999)
    • Nature , vol.397 , pp. 310-1999
    • Astrom, S.U.1    Okamura, S.M.2    Rine, J.3
  • 159
    • 0033565609 scopus 로고    scopus 로고
    • Role of yeast SIR genes and mating type in directing DNA double-strand breaks to homologous and non-homologous repair paths
    • DOI 10.1016/S0960-9822(99)80339-X
    • Lee, S. E., F. Paques, J. Sylvan & J. E. Haber: Role of yeast SIR genes and mating type in directing DNA doublestrand breaks to homologous and non-homologous repair paths. Curr Biol, 9, 767-70. (1999) (Pubitemid 29350858)
    • (1999) Current Biology , vol.9 , Issue.14 , pp. 767-770
    • Lee, S.E.1    Paques, F.2    Sylvan, J.3    Haber, J.E.4
  • 160
    • 33745496607 scopus 로고    scopus 로고
    • Cell cycle and checkpoint regulation of histone H3 K56 acetylation by Hst3 and Hst4
    • DOI 10.1016/j.molcel.2006.06.006, PII S1097276506004114
    • Maas, N. L., K. M. Miller, L. G. DeFazio & D. P. Toczyski: Cell cycle and checkpoint regulation of histone H3 K56 acetylation by Hst3 and Hst4. Mol Cell, 23, 109-19 (2006) (Pubitemid 43963450)
    • (2006) Molecular Cell , vol.23 , Issue.1 , pp. 109-119
    • Maas, N.L.1    Miller, K.M.2    DeFazio, L.G.3    Toczyski, D.P.4
  • 161
    • 33745520486 scopus 로고    scopus 로고
    • The sirtuins Hst3 and Hst4p preserve genome integrity by controlling histone H3 lysine 56 deacetylation
    • DOI 10.1016/j.cub.2006.06.023, PII S0960982206017490
    • Celic, I., H. Masumoto, W. P. Griffith, P. Meluh, R. J. Cotter, J. D. Boeke & A. Verreault: The sirtuins hst3 and Hst4p preserve genome integrity by controlling histone h3 lysine 56 deacetylation. Curr Biol, 16, 1280-9 (2006) (Pubitemid 43977885)
    • (2006) Current Biology , vol.16 , Issue.13 , pp. 1280-1289
    • Celic, I.1    Masumoto, H.2    Griffith, W.P.3    Meluh, P.4    Cotter, R.J.5    Boeke, J.D.6    Verreault, A.7
  • 162
    • 0028841317 scopus 로고
    • The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability
    • Brachmann, C. B., J. M. Sherman, S. E. Devine, E. E. Cameron, L. Pillus & J. D. Boeke: The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability. Genes Dev, 9, 2888-902. (1995)
    • (1995) Genes Dev , vol.9 , pp. 2888-2902
    • Brachmann, C.B.1    Sherman, J.M.2    Devine, S.E.3    Cameron, E.E.4    Pillus, L.5    Boeke, J.D.6
  • 163
    • 0242556798 scopus 로고    scopus 로고
    • A chromosomal SIR2 homologue with both histone NAD-dependent ADP-ribosyltransferase and deacetylase activities is involved in DNA repair in Trypanosoma brucei
    • DOI 10.1093/emboj/cdg553
    • Garcia-Salcedo, J. A., P. Gijon, D. P. Nolan, P. Tebabi & E. Pays: A chromosomal SIR2 homologue with bothhistone NAD-dependent ADP-ribosyltransferase and deacetylase activities is involved in DNA repair in Trypanosoma brucei. Embo J, 22, 5851-62 (2003) (Pubitemid 37408823)
    • (2003) EMBO Journal , vol.22 , Issue.21 , pp. 5851-5862
    • Garcia-Salcedo, J.A.1    Gijon, P.2    Nolan, D.P.3    Tebabi, P.4    Pays, E.5
  • 164
    • 34250897968 scopus 로고    scopus 로고
    • SIRT1 regulates the function of the nijmegen breakage syndrome protein
    • DOI 10.1016/j.molcel.2007.05.029, PII S1097276507003309
    • Yuan, Z., X. Zhang, N. Sengupta, W. S. Lane & E. Seto: SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Mol Cell, 27, 149-62 (2007) (Pubitemid 46991383)
    • (2007) Molecular Cell , vol.27 , Issue.1 , pp. 149-162
    • Yuan, Z.1    Zhang, X.2    Sengupta, N.3    Lane, W.S.4    Seto, E.5
  • 165
    • 0035826271 scopus 로고    scopus 로고
    • Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
    • DOI 10.1038/35065638
    • Tissenbaum, H. A. & L. Guarente: Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature, 410, 227-30. (2001) (Pubitemid 32216597)
    • (2001) Nature , vol.410 , Issue.6825 , pp. 227-230
    • Tissenbaum, H.A.1    Guarente, L.2
  • 166
    • 33744976074 scopus 로고    scopus 로고
    • C. elegans SIR-2.1 Interacts with 14-3-3 Proteins to Activate DAF-16 and Extend Life Span
    • DOI 10.1016/j.cell.2006.04.036, PII S0092867406006180
    • Berdichevsky, A., M. Viswanathan, H. R. Horvitz & L. Guarente: C. elegans SIR-2.1 interacts with 14-3-3proteins to activate DAF-16 and extend life span. Cell, 125, 1165-77 (2006) (Pubitemid 43866202)
    • (2006) Cell , vol.125 , Issue.6 , pp. 1165-1177
    • Berdichevsky, A.1    Viswanathan, M.2    Horvitz, H.R.3    Guarente, L.4
  • 167
    • 33746245679 scopus 로고    scopus 로고
    • C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO
    • DOI 10.1016/j.mad.2006.05.005, PII S0047637406001448
    • Wang, Y., S. W. Oh, B. Deplancke, J. Luo, A. J. Walhout & H. A. Tissenbaum: C. elegans 14-3-3 proteinsregulate life span and interact with SIR-2.1 and DAF-16/FOXO. Mech Ageing Dev, 127, 741-7 (2006) (Pubitemid 44188819)
    • (2006) Mechanisms of Ageing and Development , vol.127 , Issue.9 , pp. 741-747
    • Wang, Y.1    Oh, S.W.2    Deplancke, B.3    Luo, J.4    Walhout, A.J.M.5    Tissenbaum, H.A.6
  • 168
    • 28244475950 scopus 로고    scopus 로고
    • Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO
    • DOI 10.1016/j.mad.2005.09.005, PII S0047637405002216
    • Wang, Y. & H. A. Tissenbaum: Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO. Mech Ageing Dev, 127, 48-56 (2006) (Pubitemid 41713513)
    • (2006) Mechanisms of Ageing and Development , vol.127 , Issue.1 , pp. 48-56
    • Wang, Y.1    Tissenbaum, H.A.2
  • 169
    • 34447626095 scopus 로고    scopus 로고
    • SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction
    • DOI 10.1111/j.1474-9726.2007.00304.x
    • Wang, F., M. Nguyen, F. X. Qin & Q. Tong: SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction. Aging Cell, 6, 505-514 (2007) (Pubitemid 47087055)
    • (2007) Aging Cell , vol.6 , Issue.4 , pp. 505-514
    • Wang, F.1    Nguyen, M.2    Qin, F.X.-F.3    Tong, Q.4
  • 175
    • 0030038103 scopus 로고    scopus 로고
    • Oxidative stress, caloric restriction, and aging
    • Sohal, R. S. & R. Weindruch: Oxidative stress, caloric restriction, and aging. Science, 273, 59-63 (1996) (Pubitemid 26255420)
    • (1996) Science , vol.273 , Issue.5271 , pp. 59-63
    • Sohal, R.S.1    Weindruch, R.2
  • 176
    • 34249888736 scopus 로고    scopus 로고
    • PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans
    • Panowski, S. H., S. Wolff, H. Aguilaniu, J. Durieux & A. Dillin: PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. Nature, 447, 550-5 (2007)
    • (2007) Nature , vol.447 , pp. 550-555
    • Panowski, S.H.1    Wolff, S.2    Aguilaniu, H.3    Durieux, J.4    Dillin, A.5
  • 177
    • 0037066518 scopus 로고    scopus 로고
    • Dietary restriction in long-lived dwarf flies
    • DOI 10.1126/science.1069366
    • Clancy, D. J., D. Gems, E. Hafen, S. J. Leevers & L. Partridge: Dietary restriction in long-lived dwarf flies. Science, 296, 319 (2002) (Pubitemid 34303679)
    • (2002) Science , vol.296 , Issue.5566 , pp. 319
    • Clancy, D.J.1    Gems, D.2    Hafen, E.3    Leevers, S.J.4    Partridge, L.5
  • 178
    • 0032573178 scopus 로고    scopus 로고
    • The genetics of caloric restriction in Caenorhabditis elegans
    • Lakowski, B. & S. Hekimi: The genetics of caloric restriction in Caenorhabditis elegans. Proc Natl Acad Sci U S A, 95, 13091-6 (1998)
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 13091-11306
    • Lakowski, B.1    Hekimi, S.2
  • 181
    • 4544322045 scopus 로고    scopus 로고
    • Free radicals and aging
    • DOI 10.1016/j.tins.2004.07.005, PII S0166223604002334
    • Barja, G.: Free radicals and aging. Trends Neurosci, 27, 595-600 (2004) (Pubitemid 39221395)
    • (2004) Trends in Neurosciences , vol.27 , Issue.10 , pp. 595-600
    • Barja, G.1
  • 183
    • 33646731782 scopus 로고    scopus 로고
    • Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction
    • Bonkowski, M. S., J. S. Rocha, M. M. Masternak, K. A. Al Regaiey & A. Bartke: Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction. Proc Natl Acad Sci U S A, 103, 7901-5 (2006)
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 7901-7905
    • Bonkowski, M.S.1    Rocha, J.S.2    Masternak, M.M.3    Al Regaiey, K.A.4    Bartke, A.5
  • 184
    • 3943071801 scopus 로고    scopus 로고
    • Sirtuin activators mimic caloric restriction and delay ageing in metazoans
    • DOI 10.1038/nature02789
    • Wood, J. G., B. Rogina, S. Lavu, K. Howitz, S. L. Helfand, M. Tatar & D. Sinclair: Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature, 430, 686-689 (2004) (Pubitemid 39061685)
    • (2004) Nature , vol.430 , Issue.7000 , pp. 686-689
    • Wood, J.G.1    Regina, B.2    Lavu, S.3    Hewitz, K.4    Helfand, S.L.5    Tatar, M.6    Sinclair, D.7
  • 185
    • 28844469898 scopus 로고    scopus 로고
    • Medicine: Increase in activity during calorie restriction requires Sirt1
    • DOI 10.1126/science.1118357
    • Chen, D., A. D. Steele, S. Lindquist & L. Guarente: Increase in activity during calorie restriction requires Sirt1. Science, 310, 1641 (2005) (Pubitemid 41780779)
    • (2005) Science , vol.310 , Issue.5754 , pp. 1641
    • Chen, D.1    Steele, A.D.2    Lindquist, S.3    Guarente, L.4
  • 186
    • 24944559665 scopus 로고    scopus 로고
    • Cell biology: HST2 mediates SIR2-independent life-span extension by calorie restriction
    • DOI 10.1126/science.1113611
    • Lamming, D. W., M. Latorre-Esteves, O. Medvedik, S. N. Wong, F. A. Tsang, C. Wang, S. J. Lin & D. A. Sinclair: HST2 mediates SIR2-independent life-span extension by calorie restriction. Science, 309, 1861-4 (2005) (Pubitemid 41325097)
    • (2005) Science , vol.309 , Issue.5742 , pp. 1861-1864
    • Lamming, D.W.1    Latorre-Esteves, M.2    Medvedik, O.3    Wong, S.N.4    Tsang, F.A.5    Wang, C.6    Lin, S.-J.7    Sinclair, D.A.8
  • 187
    • 33746228121 scopus 로고    scopus 로고
    • Sirtuins in aging and age-related disease
    • DOI 10.1016/j.cell.2006.07.002, PII S0092867406008920
    • Longo, V. D. & B. K. Kennedy: Sirtuins in aging and age-related disease. Cell, 126, 257-68 (2006) (Pubitemid 44092970)
    • (2006) Cell , vol.126 , Issue.2 , pp. 257-268
    • Longo, V.D.1    Kennedy, B.K.2
  • 190
    • 34848927457 scopus 로고    scopus 로고
    • Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans
    • DOI 10.1016/j.mad.2007.07.007, PII S0047637407001212
    • Bass, T. M., D. Weinkove, K. Houthoofd, D. Gems & L. Partridge: Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans. Mech Ageing Dev, 128, 546-52 (2007) (Pubitemid 47498522)
    • (2007) Mechanisms of Ageing and Development , vol.128 , Issue.10 , pp. 546-552
    • Bass, T.M.1    Weinkove, D.2    Houthoofd, K.3    Gems, D.4    Partridge, L.5
  • 191
    • 17144424946 scopus 로고    scopus 로고
    • SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes
    • DOI 10.1074/jbc.M414670200
    • Shi, T., F. Wang, E. Stieren & Q. Tong: SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes. J Biol Chem, 280, 13560-7 (2005) (Pubitemid 40517248)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.14 , pp. 13560-13567
    • Shi, T.1    Wang, F.2    Stieren, E.3    Tong, Q.4
  • 193
    • 12344335482 scopus 로고    scopus 로고
    • Long-lived growth hormone receptor knockout mice: Interaction of reduced insulin-like growth factor I/insulin signaling and caloric restriction
    • DOI 10.1210/en.2004-1120
    • Al-Regaiey, K. A., M. M. Masternak, M. Bonkowski, L. Sun & A. Bartke: Long-lived growth hormone receptorknockout mice: interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction. Endocrinology, 146, 851-60 (2005) (Pubitemid 40129843)
    • (2005) Endocrinology , vol.146 , Issue.2 , pp. 851-860
    • Al-Regaiey, K.A.1    Masternak, M.M.2    Bonkowski, M.3    Sun, L.4    Bartke, A.5
  • 194
    • 14544282413 scopus 로고    scopus 로고
    • Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
    • DOI 10.1038/nature03354
    • Rodgers, J. T., C. Lerin, W. Haas, S. P. Gygi, B. M. Spiegelman & P. Puigserver: Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature, 434, 113-8 (2005) (Pubitemid 40349395)
    • (2005) Nature , vol.434 , Issue.7029 , pp. 113-118
    • Rodgers, J.T.1    Lerin, C.2    Haas, W.3    Gygi, S.P.4    Spiegelman, B.M.5    Puigserver, P.6
  • 195
    • 34247259630 scopus 로고    scopus 로고
    • Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1α
    • DOI 10.1038/sj.emboj.7601633, PII 7601633
    • Gerhart-Hines, Z., J. T. Rodgers, O. Bare, C. Lerin, S. H. Kim, R. Mostoslavsky, F. W. Alt, Z. Wu & P. Puigserver: Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. Embo J, 26, 1913-23 (2007) (Pubitemid 46624046)
    • (2007) EMBO Journal , vol.26 , Issue.7 , pp. 1913-1923
    • Gerhart-Hines, Z.1    Rodgers, J.T.2    Bare, O.3    Lerin, C.4    Kim, S.-H.5    Mostoslavsky, R.6    Alt, F.W.7    Wu, Z.8    Puigserver, P.9
  • 198
    • 34250848194 scopus 로고    scopus 로고
    • Mammalian Sir2-related protein (SIRT) 2-mediated modulation of resistance to axonal degeneration in slow Wallerian degeneration mice: A crucial role of tubulin deacetylation
    • DOI 10.1016/j.neuroscience.2007.04.059, PII S0306452207005441
    • Suzuki, K. & T. Koike: Mammalian Sir2-related protein (SIRT) 2-mediated modulation of resistance toaxonal degeneration in slow Wallerian degeneration mice: a crucial role of tubulin deacetylation. Neuroscience, 147, 599-612 (2007) (Pubitemid 46990654)
    • (2007) Neuroscience , vol.147 , Issue.3 , pp. 599-612
    • Suzuki, K.1    Koike, T.2
  • 203
    • 4944245398 scopus 로고    scopus 로고
    • Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin
    • DOI 10.1016/j.molcel.2004.08.031, PII S1097276504005180
    • Vaquero, A., M. Scher, D. Lee, H. Erdjument-Bromage, P. Tempst & D. Reinberg: Human SirT1 Interacts with Histone H1 and Promotes Formation of Facultative Heterochromatin. Mol Cell, 16, 93-105 (2004) (Pubitemid 39330155)
    • (2004) Molecular Cell , vol.16 , Issue.1 , pp. 93-105
    • Vaquero, A.1    Scher, M.2    Lee, D.3    Erdjument-Bromage, H.4    Tempst, P.5    Reinberg, D.6
  • 204
    • 0037667702 scopus 로고    scopus 로고
    • Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
    • DOI 10.1016/S0092-8674(03)00401-X
    • Narita, M., S. Nunez, E. Heard, A. W. Lin, S. A. Hearn, D. L. Spector, G. J. Hannon & S. W. Lowe: Rbmediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell, 113, 703-16 (2003) (Pubitemid 36724935)
    • (2003) Cell , vol.113 , Issue.6 , pp. 703-716
    • Narita, M.1    Nunez, S.2    Heard, E.3    Narita, M.4    Lin, A.W.5    Hearn, S.A.6    Spector, D.L.7    Hannon, G.J.8    Lowe, S.W.9
  • 207
    • 27544434763 scopus 로고    scopus 로고
    • Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses
    • DOI 10.1016/j.cell.2005.08.011, PII S0092867405008159
    • Chen, W. Y., D. H. Wang, R. C. Yen, J. Luo, W. Gu & S. B. Baylin: Tumor suppressor HIC1 directly regulatesSIRT1 to modulate p53-dependent DNA-damage responses. Cell, 123, 437-48 (2005) (Pubitemid 41546674)
    • (2005) Cell , vol.123 , Issue.3 , pp. 437-448
    • Wen, Y.C.1    Wang, D.H.2    RayWhay, C.Y.3    Luo, J.4    Gu, W.5    Baylin, S.B.6
  • 211
    • 27144475816 scopus 로고    scopus 로고
    • Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors
    • DOI 10.1038/sj.leu.2403910, PII 2403910
    • Bradbury, C. A., F. L. Khanim, R. Hayden, C. M. Bunce, D. A. White, M. T. Drayson, C. Craddock & B. M. Turner: Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors. Leukemia, 19, 1751-9 (2005) (Pubitemid 41486152)
    • (2005) Leukemia , vol.19 , Issue.10 , pp. 1751-1759
    • Bradbury, C.A.1    Khanim, F.L.2    Hayden, R.3    Bunce, C.M.4    White, D.A.5    Drayson, M.T.6    Craddock, C.7    Turner, B.M.8
  • 212
    • 34247570492 scopus 로고    scopus 로고
    • Strong expression of a longevity-related protein, SIRT1, in Bowen's disease
    • DOI 10.1007/s00403-006-0725-6
    • Hida, Y., Y. Kubo, K. Murao & S. Arase: Strong expression of a longevity-related protein, SIRT1, in Bowen's disease. Arch Dermatol Res, 299, 103-6 (2007) (Pubitemid 46669407)
    • (2007) Archives of Dermatological Research , vol.299 , Issue.2 , pp. 103-106
    • Hida, Y.1    Kubo, Y.2    Murao, K.3    Arase, S.4
  • 215
    • 0037405043 scopus 로고    scopus 로고
    • Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle
    • DOI 10.1128/MCB.23.9.3173-3185.2003
    • Dryden, S. C., F. A. Nahhas, J. E. Nowak, A. S. Goustin & M. A. Tainsky: Role for Human SIRT2 NADDependent Deacetylase Activity in Control of Mitotic Exit in the Cell Cycle. Mol Cell Biol, 23, 3173-85 (2003) (Pubitemid 36459231)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.9 , pp. 3173-3185
    • Dryden, S.C.1    Nahhas, F.A.2    Nowak, J.E.3    Goustin, A.-S.4    Tainsky, M.A.5
  • 221
    • 0036847501 scopus 로고    scopus 로고
    • DNA base excision repair of uracil residues in reconstituted nucleosome core particles
    • DOI 10.1093/emboj/cdf581
    • Nilsen, H., T. Lindahl & A. Verreault: DNA base excision repair of uracil residues in reconstituted nucleosome core particles. Embo J, 21, 5943-52 (2002) (Pubitemid 35315291)
    • (2002) EMBO Journal , vol.21 , Issue.21 , pp. 5943-5952
    • Nilsen, H.1    Lindahl, T.2    Verreault, A.3
  • 222
    • 32044435126 scopus 로고    scopus 로고
    • Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways
    • DOI 10.1101/gad.1363206
    • Levine, A. J., Z. Feng, T. W. Mak, H. You & S. Jin: Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways. Genes Dev, 20, 267-75 (2006) (Pubitemid 43200281)
    • (2006) Genes and Development , vol.20 , Issue.3 , pp. 267-275
    • Levine, A.J.1    Feng, Z.2    Mak, T.W.3    You, H.4    Jin, S.5
  • 225
    • 10744232798 scopus 로고    scopus 로고
    • Role of the insulin-like growth factor I/insulin receptor substrate 1 axis in Rad51 trafficking and DNA repair by homologous recombination
    • DOI 10.1128/MCB.23.21.7510-7524.2003
    • Trojanek, J., T. Ho, L. Del Valle, M. Nowicki, J. Y. Wang, A. Lassak, F. Peruzzi, K. Khalili, T. Skorski & K. Reiss: Role of the insulin-like growth factor I/insulin receptor substrate 1 axis in Rad51 trafficking and DNA repair by homologous recombination. Mol Cell Biol, 23, 7510-24 (2003) (Pubitemid 37271452)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.21 , pp. 7510-7524
    • Trojanek, J.1    Ho, T.2    Del Valle, L.3    Nowicki, M.4    Wang, J.Y.5    Lassak, A.6    Peruzzi, F.7    Khalili, K.8    Skorski, T.9    Reiss, K.10
  • 227
    • 0033052037 scopus 로고    scopus 로고
    • The lack of chromosomal protein Hmg1 does not disrupt cell growth but causes lethal hypoglycaemia in newborn mice
    • DOI 10.1038/10338
    • Calogero, S., F. Grassi, A. Aguzzi, T. Voigtlander, P. Ferrier, S. Ferrari & M. E. Bianchi: The lack of chromosomal protein Hmg1 does not disrupt cell growth but causes lethal hypoglycaemia in newborn mice. Nat Genet, 22, 276-80 (1999) (Pubitemid 29297255)
    • (1999) Nature Genetics , vol.22 , Issue.3 , pp. 276-280
    • Calogero, S.1    Grassi, F.2    Aguzzi, A.3    Voigtlander, T.4    Ferrier, P.5    Ferrari, S.6    Bianchi, M.E.7
  • 228
    • 11844262653 scopus 로고    scopus 로고
    • Yeast Nhp6A/B and mammalian Hmgb1 facilitate the maintenance of genome stability
    • DOI 10.1016/j.cub.2004.12.065, PII S0960982204009984
    • Giavara, S., E. Kosmidou, M. P. Hande, M. E. Bianchi, A. Morgan, F. d'Adda di Fagagna & S. P. Jackson: Yeast Nhp6A/B and mammalian Hmgb1 facilitate the maintenance of genome stability. Curr Biol,15, 68-72 (2005) (Pubitemid 40084705)
    • (2005) Current Biology , vol.15 , Issue.1 , pp. 68-72
    • Giavara, S.1    Kosmidou, E.2    Hande, M.P.3    Bianchi, M.E.4    Morgan, A.5    D'Adda Di Fagagna, F.6    Jackson, S.P.7
  • 231
    • 9444297972 scopus 로고    scopus 로고
    • Ataxia-telangiectasia mutated gene controls insulin-like growth factor I receptor gene expression in a deoxyribonucleic acid damage response pathway via mechanisms involving zinc-finger transcription factors Sp1 and WT1
    • DOI 10.1210/en.2004-0613
    • Shahrabani-Gargir, L., Pandita, T.K. & H. Werner: Ataxia-telangiectasia mutated gene controls insulin-like growth factor I receptor gene exprssion in a deoxyribonucleic acid damage response pathway via mechanisms involving zinc-finger transcription factors SP1 and WT1. Endocrinology 145, 5679-87 (2004) (Pubitemid 39564610)
    • (2004) Endocrinology , vol.145 , Issue.12 , pp. 5679-5687
    • Shahrabani-Gargir, L.1    Pandita, T.K.2    Werner, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.