Altered expression of Ape1/ref-1 in germ cell tumors and overexpression in NT2 cells confers resistance to bleomycin and radiation

Cancer Research

Volumn 61, Issue 5, 2001, Pages 2220-2225

  Robertson, Kent A ^a   Bullock, Heather A ^a   Xu, Yi ^a   Tritt, Renee ^a   Zimmerman, Erika ^a   Ulbright, Thomas M ^a   Foster, Richard S ^a   Einhorn, Lawrence H ^a   Kelley, Mark R ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; ENDONUCLEASE; TRANSCRIPTION FACTOR; TUMOR MARKER;

ARTICLE; CANCER CELL CULTURE; CELL FUNCTION; CONTROLLED STUDY; DNA BINDING; DNA DAMAGE; DNA REPAIR; ENZYME ACTIVITY; GENE OVEREXPRESSION; GENE TRANSFER; GENETIC TRANSDUCTION; GERM CELL TUMOR; HUMAN; HUMAN CELL; HUMAN TISSUE; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; RADIOSENSITIVITY;

ANTIMETABOLITES, ANTINEOPLASTIC; BLEOMYCIN; CARBON-OXYGEN LYASES; CARCINOMA, EMBRYONAL; DEOXYRIBONUCLEASE IV (PHAGE T4-INDUCED); DNA REPAIR; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; DRUG RESISTANCE, NEOPLASM; GENE TRANSFER TECHNIQUES; GERMINOMA; HUMANS; RADIATION TOLERANCE; RETROVIRIDAE; TUMOR CELLS, CULTURED;

EID: 0035266131     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Salvage chemotherapy for recurrent germ cell cancer
2. Tandem high dose chemotherapy with autologous bone marrow transplantation for initial relapse of testicular germ cell cancer
3. The measurement of cisplatin-DNA adduct levels in testicular cancer patients
4. Unusual distribution of chromosome 12 in a testicular germ-cell tumor cell line (833K) and its cisplatin-resistant derivative (64CP9)
5. The genetic and biologic aspects of treatment response and resistance in male germ cell cancer
6. 6-ethenoadenine repair by interacting with the human 3-methyladenine DNA glycosylase
7. Going APE over ref-1
8. Excision of C-4′-oxidized deoxyribose lesions from double-stranded DNA by human apurinic/apyrimidinic endonuclease (Ape1 protein) and DNA polymerase β
9. Identification of redox/repair protein Ref-1 as a potent activator of p53
10. Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo
11. Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme
12. Characterization of the DNA-binding properties of the early growth response-1 (Egr-1) transcription factor: Evidence for modulation by a redox mechanism
13. Pax genes and their roles in cell differentiation and development
14. Ref-1 controls pax-8 DNA-binding activity
15. A redox mechanism controls differential DNA binding activities of hypoxia-inducible factor (HIF) 1α and the HIF-like factor
16. Down-regulation of AP endonuclease expression is associated with the induction of apoptosis in differentiating myeloid leukemia cells
17. AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1
18. The solution structure of human thioredoxin complexed with its target from Ref-1 reveals peptide chain reversal
19. The apurinic/apyrimidinic endonuclease (APE/ref-1) DNA repair enzyme is elevated in premalignant and malignant cervical cancer
20. Alterations in the expression of the DNA repair/redox enzyme APE/ref-1 in epithelial ovarian cancers
21. Altered expression of the multifunctional DNA base excision repair and redox enzyme ape/ref-1 in ovarian and prostate cancers
22. An "environment to nucleus" signaling system operates in B lymphocytes: Redox status modulates BSAP/Pax-5 activation through Ref-1 nuclear translocation
23. The multifunctional DNA base excision repair and redox protein, AP endonuclease (APE/ref-1), and its role in germ cell tumors
24. Multiple members of the retinoic acid receptor family are capable of mediating the granulocytic differentiation of HL-60 cells
25. Improved transfer of the leukocyte integrin CD18 subunit into hematopoietic cell lines by using retroviral vectors having a gibbon ape leukemia virus envelope
26. Creation of a fully functional human chimeric DNA repair protein
27. The DNA repair activity of human redox/repair protein APE/Ref-1 is inactivated by phosphorylation
28. Improved retroviral vectors for gene transfer and expression
29. Pluripotent embryonal carcinoma clones derived from the human teratocarcinoma cell line Tera-2
30. Cell line derived from a metastasis of a human testicular germ cell tumor
31. Isolation of cDNA clones encoding a human apurinic/apyrimidinic endonuclease that corrects DNA repair and mutagenesis defects in E. Coli xth (exonuclease III) mutants
32. Trans-complementation by human apurinic endonuclease (Ape) of hypersensitivity to DNA damage and spontaneous mutator phenotype in apn1-yeast
33. Expression levels of the DNA repair enzyme HAP1 do not correlate with the radiosensitivities of human or HAP1-transfected rat cell lines
34. Apurinic/apyrimidinic endonuclease expression in pediatric yolk sac tumors
35. Human apurinic endonuclease 1 expression in a colorectal adenoma-carcinoma sequence
36. Human AP endonuclease 1 (HAP1) protein expression in breast cancer correlates with lymph node status and angiogenesis
37. Recognition of oxidized abasic sites by repair endonucleases
38. Yeast DNA 3′-repair diesterase is the major cellular apurinic/apyrimidinic endonuclease: Substrate specificity and kinetics
39. In vitro detection of endonuclease IV-specific DNA damage formed by bleomycin in vivo
40. Re: "Genetic interaction between HAP1/REF-1 and p53"