Essential role of limiting telomeres in the pathogenesis of Werner syndrome

Nature Genetics

Volumn 36, Issue 8, 2004, Pages 877-882

  Chang, Sandy ^a   Multani, Asha S ^a   Cabrera, Noelia G ^a   Naylor, Maria L ^b,c   Laud, Purnima ^a   Lombard, David ^d   Pathak, Sen ^a   Guarente, Leonard ^e   DePinho, Ronald A ^b,c  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; WERNER SYNDROME PROTEIN;

AGING; ALOPECIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOSOMAL RECESSIVE DISORDER; CANCER INCIDENCE; CATARACT; CELL CULTURE; CONTROLLED STUDY; DEATH; DISEASE MODEL; DNA DAMAGE; GENE; GENE EXPRESSION; GENE FUNCTION; GENE INACTIVATION; GENE LOCUS; GENE MUTATION; GENETIC STABILITY; HAIR COLOR; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OSTEOPOROSIS; PATHOGENESIS; PHENOTYPE; PLEIOTROPY; PREMATURE AGING; PRIORITY JOURNAL; SENESCENCE; TELOMERE; WERNER SYNDROME; WRN GENE;

AGING, PREMATURE; ANIMALS; APOPTOSIS; CELL AGING; CELLS, CULTURED; CHROMOSOMAL INSTABILITY; DIABETES MELLITUS, TYPE 2; DNA DAMAGE; FEMALE; LIFE EXPECTANCY; MICE; MICE, MUTANT STRAINS; NEOPLASMS, EXPERIMENTAL; TELOMERE; WERNER SYNDROME; WOUND HEALING;

ANIMALIA;

EID: 3543043128     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng1389     Document Type: Article

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