Sirtuin activators mimic caloric restriction and delay ageing in metazoans

Nature

Volumn 430, Issue 7000, 2004, Pages 686-689

  Wood, Jazon G ^a   Regina, Blanka ^b   Lavu, Siva ^a   Hewitz, Konrad ^c   Helfand, Stephen L ^b   Tatar, Marc ^d   Sinclair, David ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^c BIOMOL Research Laboratories Inc   (United States)

^d BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; FUNCTIONS; YEAST;

CALORIC RESTRICTION; HUMAN CELLS;

BIODIVERSITY;

SILENT INFORMATION REGULATOR PROTEIN 2; SIRTUIN; SIRTUIN ACTIVATING COMPOUND; UNCLASSIFIED DRUG; FISETIN; FLAVONOID; PHENOL DERIVATIVE; POLYPHENOLS; RESVERATROL; STILBENE DERIVATIVE;

METAZOAN;

AGING; ARTICLE; CAENORHABDITIS ELEGANS; CALORIC RESTRICTION; CELL SURVIVAL; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; FERTILITY; GENE REPLICATION; HUMAN; LIFESPAN; METAZOON; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; YEAST; ALLELE; ANIMAL; ANIMAL FOOD; DRUG EFFECT; DRUG POTENTIATION; FEEDING BEHAVIOR; FEMALE; GENETICS; GENOTYPE; LONGEVITY; MALE; METABOLISM; MUTATION; PHYSIOLOGY; SURVIVAL RATE; TIME;

ANIMALIA; CAENORHABDITIS; CAENORHABDITIS ELEGANS; DROSOPHILA MELANOGASTER; INVERTEBRATA; MELANOGASTER; METAZOA; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES;

AGING; ALLELES; ANIMAL FEED; ANIMALS; CAENORHABDITIS ELEGANS; CALORIC RESTRICTION; DROSOPHILA MELANOGASTER; FEEDING BEHAVIOR; FEMALE; FERTILITY; FLAVONOIDS; GENOTYPE; LONGEVITY; MALE; MUTATION; PHENOLS; SIRTUINS; STILBENES; SURVIVAL RATE; TIME FACTORS;

EID: 3943071801     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02789     Document Type: Article

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