Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase

Science

Volumn 303, Issue 5666, 2004, Pages 2011-2015

  Brunet, Anne ^a,c   Sweeney, Lora B ^a   Sturgill, J Fitzhugh ^a   Chua, Katrin F ^a   Greer, Paul L ^a   Lin, Yingxi ^a   Tran, Hien ^a   Ross, Sarah E ^a   Mostoslavsy, Raul ^a   Cohen, Haim Y ^b   Hu, Linda S ^a   Cheng, Hwei Ling ^a   Jedrychowski, Mark P ^b   Gygi, Steven P ^b   Sinclair, David A ^b   Alt, Frederick W ^a   Greenberg, Michael E ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; PROTEINS; SENSORS; STRESS ANALYSIS;

CELL DEATH; CELLULAR RESPONSES;

CATALYST ACTIVITY;

SIR2 DEACETYLASE; SIRT1 DEACETYLASE; SIRTUIN; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG;

BIOLOGY;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL DEATH; COMPLEX FORMATION; LIFESPAN; LONGEVITY; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STRESS;

ACETYLATION; ANIMALS; APOPTOSIS; CELL CYCLE; CELL LINE; CELL NUCLEUS; CELLS, CULTURED; CEREBELLUM; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HISTONE DEACETYLASES; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, KNOCKOUT; NEURONS; OXIDATIVE STRESS; PHOSPHORYLATION; PROTEINS; RECOMBINANT PROTEINS; SIRTUINS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

MAMMALIA;

EID: 12144290563     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1094637     Document Type: Article

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31. -/- MEFs. Supported by a Senior Scholars Award from the Ellison Foundation, NIH grant no. PO1 NS35138-17, and Mental Retardation Research Center grant no. NIHP30-HD18655 [M.E.G.). M.E.G. acknowledges the generous contribution of the F. M. Kirby Foundation to the Division of Neuroscience. A.B. is supported by a fellowship from the Radcliffe Institute for Advanced Studies. F.W.A. is a Howard Hughes Medical Institute investigator and is supported by an Ellison Medical Foundation Senior Scholar Award. K.C. is supported by a Pfizer postdoctoral fellowship in Rheumatology/Immunology, and R.M. by a postdoctoral fellowship from the Human Frontiers Science Program.