Cell biology: Regulation of yeast replicative life span by TOR and Sch9 response to nutrients

Science

Volumn 310, Issue 5751, 2005, Pages 1193-1196

  Kaeberlein, Matt ^a   Powers III, R Wilson ^a   Steffen, Kristan K ^b   Westman, Eric A ^b   Hu, Di ^b   Dang, Nick ^b   Kerr, Emily O ^b   Kirkland, Kathryn T ^b   Fields, Stanley ^a   Kennedy, Brian K ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; ENZYME KINETICS; GENES;

SIR2 HISTONE DEACETYLASE; YEAST SACCHAROMYCES CEREVISIAE;

YEAST;

CYCLIC AMP DEPENDENT PROTEIN KINASE; PROTEIN KINASE; PROTEIN KINASE C; PROTEIN KINASE SCH9; RIBOSOME DNA; RIBOSOME PROTEIN; TARGET OF RAPAMYCIN KINASE; UNCLASSIFIED DRUG; SACCHAROMYCES CEREVISIAE PROTEIN; SCH9 PROTEIN KINASE; TARGET OF RAPAMYCIN PROTEIN, S CEREVISIAE;

CYTOLOGY;

AGING; ARTICLE; CALORIC RESTRICTION; ENZYME ACTIVITY; GENE DELETION; LIFESPAN; LONGEVITY; NONHUMAN; NUTRIENT; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; YEAST; CELL DIVISION; GENETICS; METABOLISM; PHYSIOLOGY;

SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES;

CELL DIVISION; GENE DELETION; PROTEIN KINASES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 27744511769     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1115535     Document Type: Article

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25. We thank G. Martin and P. Rabinovitch for advice and helpful discussion. M.K. is supported by NIH training grant P30 AG013280 and by the Ellison Medical Foundation. This work was funded by awards to B.K. from the University of Washington Nathan Shock Center of Excellence for the Basic Biology of Aging, the American Federation for Aging Research, and the Ellison Medical Foundation. S.F. is an investigator of the Howard Hughes Medical Institute. B.K. is a Searle scholar. M.K. cofounded and served as vice president, Biology of Aging Research for Longenity, Inc., until May 2003.